Ischaemic Preconditioning Of The Human Heart
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Ischaemic Preconditioning Of The Human Heart
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Author : Sudip Ghosh
language : en
Publisher:
Release Date : 2003
Ischaemic Preconditioning Of The Human Heart written by Sudip Ghosh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Effect Of Remote Ischemic Preconditioning Of Human Heart During Coronary Artery Bypass Grafting
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Author : Erika Anna Hernekamp
language : en
Publisher:
Release Date : 2017
Effect Of Remote Ischemic Preconditioning Of Human Heart During Coronary Artery Bypass Grafting written by Erika Anna Hernekamp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Ischaemia
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Author : M. Marber
language : en
Publisher: BIOS Scientific Publishers
Release Date : 1996-07-01
Ischaemia written by M. Marber and has been published by BIOS Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-01 with Science categories.
Most research on myocardial protection is now focused on ischaemic preconditioning. This book is a unique collection of articles by researchers at the cutting edge of preconditioning research. Using a multidisciplinary approach, it presents information on the mechanisms of preconditioning and examines how these mechanisms are relevant to the human heart.
The Impact Of Remote Ischaemic Preconditioning On The Human Plasma Proteome
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Author : Joanne Michelle Hepponstall
language : en
Publisher:
Release Date : 2014
The Impact Of Remote Ischaemic Preconditioning On The Human Plasma Proteome written by Joanne Michelle Hepponstall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Heart categories.
An Investigation Of The Mechanism Of Ischaemic Preconditioning
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Author : Marie Elsya Speechly-Dick
language : en
Publisher:
Release Date : 1996
An Investigation Of The Mechanism Of Ischaemic Preconditioning written by Marie Elsya Speechly-Dick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Patterns Of Ischaemic Preconditioning On The Viability Of Rat Heart
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Author : Katherine Jane Hewitt
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012-04
Patterns Of Ischaemic Preconditioning On The Viability Of Rat Heart written by Katherine Jane Hewitt and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04 with categories.
Ischaemic preconditioning is a phenomenon where brief periods of ischaemia and reperfusion prior to a prolonged episode of ischaemia have a protective effect on tissue. Ischaemic preconditioning has been demonstrated in every animal species tested and many different tissues, including human myocardium (Yellon et al, 1993), (Hausenloy et al, 2007). Many different patterns of ischaemic preconditioning have been tested (Kloner and Jennings, 2001 a), and this investigation aimed to identify a pattern of ischaemic preconditioning that promoted protective effects in a rat heart strip model, with recovery of contractile function as end-point assessment. Three different patterns of ischaemia and reperfusion were tested and compared to a control group which received no preconditioning ischaemia. After preconditioning, all four groups were exposed to 30 minutes of ischaemia and 30 minutes reperfusion. Results showed some preconditioning effects in group 3 although statistical analysis found the results not to be significant. However, the pattern used in group 4 was found to exacerbate ischaemic damage, which was unexpected. Further testing is suggested.
Analytical And Quantitative Cardiology
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Author : S. Sideman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Analytical And Quantitative Cardiology written by S. Sideman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The tenth Henry Goldberg Workshop is an excellent occasion to recall our goals and celebrate some of our humble achievements. Vision and love of our fellow man are combined here to: 1) Foster interdisciplinary interaction between leading world scientists and clinical cardiologists so as to identify missing knowledge and catalyze new research ideas; 2) relate basic microscale, molecular and subcellular phenomena to the global clinically manifested cardiac performance; 3) apply conceptual modelling and quantitative analysis to better explore, describe, and understand cardiac physiology; 4) interpret available clinical data and design new revealing experiments; and 5) enhance international cooperation in the endless search for the secrets of life and their implication on cardiac pathophysiology. The first Goldberg Workshop, held in Haifa, in 1984, explored the interaction of mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University, in 1986, highlighted the transformation of the microscale activation phenomena to macro scale activity and performance, relating electrophysiology, energy metabolism and cardiac mechanics. The fourth Goldberg Workshop continued the effort to elucidate the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop concentrated on the effect of the inhomogeneity of the cardiac muscle on its performance. The sixth Workshop highlighted new imaging techniques which allow insight into the local and global cardiac performance.
Cardioprotection Against Acute Myocardial Infarction
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Author : Shinya Minatoguchi
language : en
Publisher: Springer Nature
Release Date : 2019-11-16
Cardioprotection Against Acute Myocardial Infarction written by Shinya Minatoguchi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-16 with Science categories.
This book will provide readers with a detailed understanding of the ischemic damage to the myocardium after myocardial infarction, as well as essential tools for the treatment of damaged heart after myocardial infarction. It discusses various methods such as pharmacological pre- and post-conditioning, cytokine therapy, and cell therapy especially using Muse cells.The coverage of Muse cell therapy, which includes the latest work done by the author and his collaborators, is a unique feature of the book. Muse cells have self-renewability and have ability to differentiate into cells with the characteristics of all three germ layers from a single cell, while they are non-tumorigenic. It is the first book to feature the Muse cell therapy, which may offer the new promising therapeutic strategy for acute myocardial infarction.
Developmental Change In Myocardial Ischaemic Preconditioning
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Author : Max Baghai
language : en
Publisher:
Release Date : 2010
Developmental Change In Myocardial Ischaemic Preconditioning written by Max Baghai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Coronary heart disease categories.
We have recently shown that there is a neonatal developmental change in the ability of the heart to be protected by ischemic preconditioning (IPC) which matures over the first 21 days in the rat and the first year of life in the human. While there is much controversy surrounding the exact signalling pathway involved in preconditioning, evidence suggests it involves - activation of G-protein coupled receptors -protein kinase activation - mitochondrial KATP (MITOKATP) channel opening - mitochondrial depolarisation - reactive oxygen species generation - inhibition of the mitochondrial permeability transition pore (MPTP) leading to cardioprotection. The aim of these studies was to establish which part(s) of this putative cascade is/are immature in human and rat neonatal hearts. -- Human right atrial tissue was obtained during elective surgery for congenital defects and was used in Western blotting and contractility/cardioprotection studies (Note: no differences in atrial vs ventricular developmental changes in preconditioning have been previously observed). Isolated rat hearts were also used. In the human, the age groups of the patients were defined as neonatal (28 days), infant (1-12 months), paediatric (1-14 yrs) and adult (67 ± 8 yrs). The age group of the rats were defined as 4, 7, 10 days old and Adult (30 days old). In the human cardioprotection experiments, small (
Endothelial Progenitor Cells And Remote Ischaemic Preconditioning
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Author : Mrinal Saha
language : en
Publisher:
Release Date : 2010
Endothelial Progenitor Cells And Remote Ischaemic Preconditioning written by Mrinal Saha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Coronary heart disease categories.
Background. Stem cell therapy and remote ischaemic preconditioning (RIPC) are emerging as potential strategies to protect the heart. Endothelial progenitor cells (EPCs) are a subset of stem cells which are thought to contribute to endothelial health, but their role in RIPC remains unclear. - Methods. An assay for the characterization of EPC's was developed using flow cytometry to enumerate CD133+/CD34+ cells. To validate this assay, EPC's were compared against endothelial function in a study comparing hypertensive individuals and healthy control subjects. The effect of intermittent limb ischaemia upon the warm-up angina phenomenon was then investigated, a potential human model of ischaemic preconditioning. This would determine whether the warm-up effect was affected by remote ischaemic preconditioning, abrogated by the free radical scavenger N-acetylcysteine (MAC), and whether EPC's correlated with changes observed. -- Results. A rapid, reproducible assay to enumerate EPCs was developed. EPCs appeared to correlate with hypertension, age and smoking in test subjects, but not with endothelial function as measured by flow-mediated dilatation (FMD). No correlation was found between EPCs and the protective effects of warm up angina. However, RIPC appeared to confer benefit in patients who manifested warm up angina. Furthermore, MAC appeared to abrogate protection of warm up angina, but not in the presence of RIPC. -- Conclusions. EPCs may be a useful biomarker of stable cardiovascular disease, but appear not to correlate with more acute changes in myocardial ischaemia. RIPC may be beneficial to some patients with ischaemic heart disease who manifest the warm up angina phenomenon. MAC appeared to abrogate the warm up effect, but not the protection conferred by RIPC.