Islet Cell Growth Factors
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Islet Cell Growth Factors
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Author : Rohit N. Kulkarni
language : en
Publisher: CRC Press
Release Date : 2011-02-07
Islet Cell Growth Factors written by Rohit N. Kulkarni and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-07 with Science categories.
This book, Islet Cell Growth Factors, provides a timely contribution to the current thinking regarding the concepts in the area of islet cell regeneration with special reference to insulin secreting beta cells. The contributions are from leaders in the field with a long-standing interest in the area of islet biology.In the first chapter Drs. Dirice
Pancreatic Islet Cell Regeneration And Growth
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Author : Aaron I. Vinik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pancreatic Islet Cell Regeneration And Growth written by Aaron I. Vinik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.
Islet Cell Growth Factors
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Author :
language : en
Publisher:
Release Date : 2011
Islet Cell Growth Factors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cell proliferation categories.
This book, "Islet Cell Growth Factors", provides a timely contribution to the current thinking regarding the concepts in the area of islet cell regeneration with special reference to insulin secreting beta cells. The contributions are from leaders in the field with a long-standing interest in the area of islet biology. In the first chapter Drs. Dirice and Kulkarni provide a broad introduction to the topic of islet cell regeneration with a focus on growth factor pathways, especially the insulin and insulin-like growth factor signaling mechanisms affecting beta cells in Type 1, Type 2 and gestati.
Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: CRC Press
Release Date : 1991-05-28
Insulin Like Growth Factors written by Derek LeRoith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-28 with Medical categories.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Pancreatic Specific Insulin Like Growth Factor I Gene Deficiency On Islet Cell Growth And Protection
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Author : Yarong Lu
language : en
Publisher:
Release Date : 2006
Pancreatic Specific Insulin Like Growth Factor I Gene Deficiency On Islet Cell Growth And Protection written by Yarong Lu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
"The role of insulin-like growth factor I (IGF-I) in pancreatic islet cell growth and development has been debated in recent years. The dogma that IGF-I stimulates pancreatic islet growth has been challenged by combinational targeting of IGF or IGF-IR genes, as well as beta-cell-specific IGF-IR gene deficiency. In order to assess the physiological role of locally produced IGF-I, we have developed pancreatic-specific IGF-I gene deficiency (PID) by crossing Pdx1-Cre and IGF-I/loxP mice. PID mice were normal except for decreased blood glucose level and a 2.3-fold enlarged islet cell mass. When challenged with low doses of streptozotocin, control mice developed hyperglycemia after 6 days that was maintained at high levels for at least 2 months. In contrast, PID mice only exhibited marginal hyperglycemia after 12 days, maintained throughout the experiment. Furthermore, streptozotocin-induced beta-cell apoptosis (TUNEL assay) was significantly prevented in PID mice. PID mice also exhibited a delayed onset of type 2 diabetes induced by a high-fat diet, accompanied by super enlarged pancreatic islets and preserved sensitivity to insulin. As the phenotype is unlikely a direct consequence of IGF-I deficiency, we used oligonucleotide DNA microarray to explore possible activation of pro-islet genes in PID mice, which revealed upregulation of multiple new members of the Reg family genes (Reg2, 3alpha and 3beta) in the pancreas. The results were subsequently confirmed by Northern blot and/or realtime PCR, which exhibited 2 to 8 fold increases in the level of their mRNAs. Moreover, these Reg family genes were also activated following streptozotocin-induced beta-cell damage and diabetes. Our results reveal a possible mechanism of islet growth and protection in PID mice, thus serving a potential strategy in combating diabetes." --
The Role Of Connective Tissue Growth Factor In Islet Morphogenesis And Beta Cell Proliferation
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Author : Michelle Guney
language : en
Publisher:
Release Date : 2011
The Role Of Connective Tissue Growth Factor In Islet Morphogenesis And Beta Cell Proliferation written by Michelle Guney and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Electronic dissertations categories.
The Effects Of Growth Factors On Proliferation Of Adult Porcine Islets In Vitro
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Author : Christa M. Donofrio
language : en
Publisher:
Release Date : 1997
The Effects Of Growth Factors On Proliferation Of Adult Porcine Islets In Vitro written by Christa M. Donofrio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Cell culture categories.
Growth Factor Modulation Of Cytokine Mediated Cell Death And Fas Expression In Insulin Containing Cells
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Author : Moira Joan Harrison
language : en
Publisher:
Release Date : 2000
Growth Factor Modulation Of Cytokine Mediated Cell Death And Fas Expression In Insulin Containing Cells written by Moira Joan Harrison and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Handbook Of Growth Factors
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Author : Enrique Pimentel
language : en
Publisher: CRC Press
Release Date : 1994-06-02
Handbook Of Growth Factors written by Enrique Pimentel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-02 with Science categories.
Volume II of Handbook of Growth Factors presents a stimulating discussion of the best-characterized polypeptide growth factors, including insulin, insulin-like growth factors, epidermal growth factor, fibroblast growth factors, neurotrophic growth factors, and transforming growth factors. The structure and function of each growth factor is discussed, as well as its receptor and postreceptor mechanism of action and its role in neoplastic processes. Regulatory peptides with growth factor-like properties such as bombesin, angiotensin, endothelin, atrial natriuretic factor, vasoactive intestinal peptide, and bradykinin are examined in depth. Factors related to the growth of organs such as the prostate, the heart, and the mammary gland are also covered.
Stem Cell Therapy For Diabetes
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Author : Shimon Efrat
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-01
Stem Cell Therapy For Diabetes written by Shimon Efrat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Medical categories.
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.