Pancreatic Islet Cell Regeneration And Growth
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Pancreatic Islet Cell Regeneration And Growth
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Author : Aaron I. Vinik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pancreatic Islet Cell Regeneration And Growth written by Aaron I. Vinik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.
Islet Cell Growth Factors
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Author : Rohit N. Kulkarni
language : en
Publisher: CRC Press
Release Date : 2011-02-07
Islet Cell Growth Factors written by Rohit N. Kulkarni and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-07 with Science categories.
This book, Islet Cell Growth Factors, provides a timely contribution to the current thinking regarding the concepts in the area of islet cell regeneration with special reference to insulin secreting beta cells. The contributions are from leaders in the field with a long-standing interest in the area of islet biology.In the first chapter Drs. Dirice
Pancreatic Islet Biology
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Author : Anandwardhan A. Hardikar
language : en
Publisher: Springer
Release Date : 2016-10-25
Pancreatic Islet Biology written by Anandwardhan A. Hardikar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-25 with Science categories.
This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.
Pancreatic Stem Cells
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Author : Juan Domínguez-Bendala
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-18
Pancreatic Stem Cells written by Juan Domínguez-Bendala and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-18 with Science categories.
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes
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Author : David J. Hill
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-12-02
Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes written by David J. Hill and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-02 with Science categories.
Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas
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Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2019-11-10
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes
Pancreatic Growth And Regeneration
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Author : Nora Sarvetnick
language : en
Publisher: S Karger Ag
Release Date : 1997-01-01
Pancreatic Growth And Regeneration written by Nora Sarvetnick and has been published by S Karger Ag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Science categories.
This book describes the roles of growth factors in the pancreas. The functions of these molecules is discussed for both the disease state as well as for the normal development of the pancreas. The purpose is to gather together the most current data from experts in this field and develop an integrated viewpoint of this topic for a range of readers. The ultimate goal of studying growth factors is to develop ways in which we could stimulate pancreas repair in the disease state (diabetes), thus the purpose of the book is far-reaching. The range of topics discussed is large and includes descriptions of transcription factors acting at the molecular level to transgenic mouse experiments as well as clinical trials carried out in human patients.
Stem Cell Therapy For Diabetes
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Author : Shimon Efrat
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-01
Stem Cell Therapy For Diabetes written by Shimon Efrat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Medical categories.
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.
Pancreatic Stem Cells
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Author : Juan Domínguez-Bendala
language : en
Publisher: Humana Press
Release Date : 2010-11-16
Pancreatic Stem Cells written by Juan Domínguez-Bendala and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Science categories.
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
Pancreas And Beta Cell Replacement
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Author : Wayne Hawthorne
language : en
Publisher: Academic Press
Release Date : 2022-04-21
Pancreas And Beta Cell Replacement written by Wayne Hawthorne and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-21 with Science categories.
Pancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observation that the regenerative medicine field is progressing at such a fast pace that the way we currently think and practice transplant medicine is rapidly changing, faster than we could ever imagine. This series was therefore conceived to bring together experts from both the transplant and regenerative medicine fields, to share knowledge first, but also to introduce the transplant audience to the remarkable progress that has occurred in regenerative medicine over the past few decades. At the same time, we intend to illustrate to researchers and operators in the regenerative medicine field the numerous platforms that transplant medicine offers for the application of their technologies. To the publisher and the editors of this series and volumes there is no doubt that regenerative medicine will shape and define the future of transplant medicine. This volume focuses on pancreas and beta cell replacement and illustrates how progress in biomaterial sciences, stem cell biology, gene editing, cell, tissue and organ bioengineering and regeneration, along with advances in xenotransplantation are revolutionizing the field. Written by the world’s experts in the fields of pancreas, islet and xenotransplantation, as well as regenerative medicine, it represents a valuable educational tool for those in the fields of clinical transplantation, researchers in the field of regenerative medicine, transplant medicine, diabetes and immunology, as well as for medical and health science students, those in academia, the biotech industry and regulatory agencies working to advance the field. At the end of the book, it will become clear to the reader that beta cell replacement offers a vast array of platforms for the application of regenerative medicine technologies to transplant medicine. First volume in the Regenerative and Transplant Medicine series, focusing on the pancreas Includes an overview of the field, including developments of transplantation methods and techniques Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals