Pancreas And Beta Cell Replacement
DOWNLOAD
Download Pancreas And Beta Cell Replacement PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Pancreas And Beta Cell Replacement book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Pancreas And Beta Cell Replacement
DOWNLOAD
Author : Wayne Hawthorne
language : en
Publisher: Academic Press
Release Date : 2022-04-21
Pancreas And Beta Cell Replacement written by Wayne Hawthorne and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-21 with Science categories.
Pancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observation that the regenerative medicine field is progressing at such a fast pace that the way we currently think and practice transplant medicine is rapidly changing, faster than we could ever imagine. This series was therefore conceived to bring together experts from both the transplant and regenerative medicine fields, to share knowledge first, but also to introduce the transplant audience to the remarkable progress that has occurred in regenerative medicine over the past few decades. At the same time, we intend to illustrate to researchers and operators in the regenerative medicine field the numerous platforms that transplant medicine offers for the application of their technologies. To the publisher and the editors of this series and volumes there is no doubt that regenerative medicine will shape and define the future of transplant medicine. This volume focuses on pancreas and beta cell replacement and illustrates how progress in biomaterial sciences, stem cell biology, gene editing, cell, tissue and organ bioengineering and regeneration, along with advances in xenotransplantation are revolutionizing the field. Written by the world’s experts in the fields of pancreas, islet and xenotransplantation, as well as regenerative medicine, it represents a valuable educational tool for those in the fields of clinical transplantation, researchers in the field of regenerative medicine, transplant medicine, diabetes and immunology, as well as for medical and health science students, those in academia, the biotech industry and regulatory agencies working to advance the field. At the end of the book, it will become clear to the reader that beta cell replacement offers a vast array of platforms for the application of regenerative medicine technologies to transplant medicine. First volume in the Regenerative and Transplant Medicine series, focusing on the pancreas Includes an overview of the field, including developments of transplantation methods and techniques Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Islet Transplantation And Beta Cell Replacement Therapy
DOWNLOAD
Author : A. M. James Shapiro
language : en
Publisher: CRC Press
Release Date : 2007-07-25
Islet Transplantation And Beta Cell Replacement Therapy written by A. M. James Shapiro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Medical categories.
Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and b
Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes
DOWNLOAD
Author : David J. Hill
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-12-02
Control Of Pancreatic Beta Cell Function And Plasticity In Health And Diabetes written by David J. Hill and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-02 with Science categories.
Plasticity in insulin-producing cells (β-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic β-cells for the reversal of diabetes (by optimizing β-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of β-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about β-cell plasticity: -current knowledge of pancreatic β-cells development, and how β-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for β-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and β-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of β-cells in the quest to find a reliable therapy for diabetes.
Pancreatic Beta Cell In Health And Disease
DOWNLOAD
Author : Susumu Seino
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-08
Pancreatic Beta Cell In Health And Disease written by Susumu Seino and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-08 with Science categories.
The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas
DOWNLOAD
Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2019-11-10
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes
In Vivo Transdifferentiation Of Liver Cells Into Pancreatic Beta Cells
DOWNLOAD
Author : Abdullah Çim
language : en
Publisher:
Release Date : 2011
In Vivo Transdifferentiation Of Liver Cells Into Pancreatic Beta Cells written by Abdullah Çim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Diabetes categories.
The autoimmune destruction of pancreatic [beta] cells results in complete loss of insulin and high blood glucose levels in type 1 diabetes mellitus (T1DM). Current approaches to treat T1DM, including insulin injections and insulin pumps, are not sufficient to control blood glucose precisely and do not prevent long-term complications of T1DM. Physiological blood glucose regulation in patients with T1DM requires pancreatic [beta] cell replacement. The advancements in the efficiency and safety of gene transfer methods to the liver encouraged us to apply gene therapy for the direct reprogramming of liver cells into pancreatic [beta] cells (transdifferentiation) in vivo, using genes for transcription factors. The genes for rat transcription factors Pdx1, Ngn3 and MafA were prepared by PCR. Four plasmids containing different functional elements including CMV promoter, liver-specific promoter, ubiquitous chromatin-opening element (UCOE) and long (10kb) genomic promoter were constructed. A fifth plasmid (pCpG) was CpG-depleted and contained elongation factor-l[alpha] (EF-l[alpha]) promoter. All plasmids contained scaffold/matrix attachment region(s) (S/MARs). The five expression plasmids encoding Pdx1 were delivered to livers of normoglycaemic DA strain rats using the hydrodynamic approach via the isolated inferior vena cava segment. Livers were removed 1, 3, 7, 14 and 28 days after gene delivery. There were 3 or 4 rats per group. Livers were assayed for the level and longevity of Pdx1 expression, and for evidence of transdifferentiation towards pancreas phenotype under the influence of Pdx1 alone by TaqMan quantitative PCR, semi-quantitative PCR and immunohistology. Initial evaluation of Pdx1 expression showed the highest and most prolonged expression from the CpG-depleted plasmid with EF-l[alpha] promoter and a plasmid with CMV promoter [pEPI(CMV)].
Beta Cells In Health And Disease
DOWNLOAD
Author : Shahzad Irfan
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-01-17
Beta Cells In Health And Disease written by Shahzad Irfan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-17 with Medical categories.
Beta Cells in Health and Disease presents the latest information on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This book includes chapters on a variety of topics, including the importance and the biology of insulin hormone, pancreatic beta cell dysfunction in type 1 diabetes, the biological importance of physical activity in managing type 1 diabetes, the use of stem cell therapy for the treatment of diabetes, the role of microRNAs in modulating beta cell function, and more.
Pancreatic Stem Cells
DOWNLOAD
Author : Juan Domínguez-Bendala
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-10
Pancreatic Stem Cells written by Juan Domínguez-Bendala and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-10 with Science categories.
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
The Roles Of Pancreatic Hormones In Regulating Pancreas Development And Beta Cell Regeneration
DOWNLOAD
Author : Lihua Ye
language : en
Publisher:
Release Date : 2015
The Roles Of Pancreatic Hormones In Regulating Pancreas Development And Beta Cell Regeneration written by Lihua Ye and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Cell proliferation categories.
Diabetes mellitus is a group of related metabolic diseases that share a common pathological mechanism: insufficient insulin signaling. Insulin is a hormone secreted from pancreatic beta cells that promotes energy storage and consequently lowers blood glucose. In contrast, the hormone glucagon, released by pancreatic alpha cells, plays a critical complementary role in metabolic homeostasis by releasing energy stores and increasing blood glucose. Restoration of beta cell mass in diabetic patients via beta cell regeneration is a conceptually proven approach to finally curing diabetes. Moreover, in situ regeneration of beta cells from endogenous sources would circumvent many of the obstacles encountered by surgical restoration of beta cell mass via islet transplantation. Regeneration may occur both by beta cell self-duplication and by neogenesis from non-beta cell sources. Although the mechanisms regulating the beta cell replication pathway have been highly investigated, the signals that regulate beta cell neogenesis are relatively unknown. In this dissertation, I have used zebrafish as a genetic model system to investigate the process of beta cell neogenesis following insulin signaling depletion by various modes. Specifically, I have found that after their ablation, beta cells primarily regenerate from two discrete cellular sources: differentiation from uncommitted pancreatic progenitors and transdifferentiation from alpha cells. Importantly, I have found that insulin and glucagon play crucial roles in controlling beta cell regeneration from both sources. As with metabolic regulation, insulin and glucagon play counter-balancing roles in directing endocrine cell fate specification. These studies have revealed that glucagon signaling promotes beta cell formation by increasing differentiation of pancreas progenitors and by destabilizing alpha cell identity to promote alpha to beta cell transdifferentiation. In contrast, insulin signaling maintains pancreatic progenitors in an undifferentiated state and stabilizes alpha cell identity. Finally, I have shown that insulin also regulates pancreatic exocrine cell development. Insufficient insulin signaling destabilized acinar cell fate and impairs exocrine pancreas development. By understanding the roles of pancreatic hormones during pancreas development and regeneration can provide new therapeutic targets for in vivo beta cell regeneration to remediate the devastating consequences of diabetes.
Pancreatic Islet Cell Regeneration And Growth
DOWNLOAD
Author : Aaron I. Vinik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pancreatic Islet Cell Regeneration And Growth written by Aaron I. Vinik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.