Pancreatic Growth And Regeneration
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Pancreatic Growth And Regeneration
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Author : Nora Sarvetnick
language : en
Publisher: S Karger Ag
Release Date : 1997-01-01
Pancreatic Growth And Regeneration written by Nora Sarvetnick and has been published by S Karger Ag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Science categories.
This book describes the roles of growth factors in the pancreas. The functions of these molecules is discussed for both the disease state as well as for the normal development of the pancreas. The purpose is to gather together the most current data from experts in this field and develop an integrated viewpoint of this topic for a range of readers. The ultimate goal of studying growth factors is to develop ways in which we could stimulate pancreas repair in the disease state (diabetes), thus the purpose of the book is far-reaching. The range of topics discussed is large and includes descriptions of transcription factors acting at the molecular level to transgenic mouse experiments as well as clinical trials carried out in human patients.
Pancreatic Islet Cell Regeneration And Growth
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Author : Aaron I. Vinik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pancreatic Islet Cell Regeneration And Growth written by Aaron I. Vinik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.
Molecular And Cellular Mechanisms Regulating Exocrine Pancreas Growth And Regeneration
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Author : Matthew David Keefe
language : en
Publisher:
Release Date : 2014
Molecular And Cellular Mechanisms Regulating Exocrine Pancreas Growth And Regeneration written by Matthew David Keefe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Developmental biology categories.
Pancreatic Stem Cells
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Author : Juan Domínguez-Bendala
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-10
Pancreatic Stem Cells written by Juan Domínguez-Bendala and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-10 with Science categories.
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas
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Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2019-11-10
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes
Pancreas Kidney And Skin Regeneration
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Author : Phuc Van Pham
language : en
Publisher: Springer
Release Date : 2017-06-07
Pancreas Kidney And Skin Regeneration written by Phuc Van Pham and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-07 with Science categories.
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
The Roles Of Pancreatic Hormones In Regulating Pancreas Development And Beta Cell Regeneration
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Author : Lihua Ye
language : en
Publisher:
Release Date : 2015
The Roles Of Pancreatic Hormones In Regulating Pancreas Development And Beta Cell Regeneration written by Lihua Ye and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Cell proliferation categories.
Diabetes mellitus is a group of related metabolic diseases that share a common pathological mechanism: insufficient insulin signaling. Insulin is a hormone secreted from pancreatic beta cells that promotes energy storage and consequently lowers blood glucose. In contrast, the hormone glucagon, released by pancreatic alpha cells, plays a critical complementary role in metabolic homeostasis by releasing energy stores and increasing blood glucose. Restoration of beta cell mass in diabetic patients via beta cell regeneration is a conceptually proven approach to finally curing diabetes. Moreover, in situ regeneration of beta cells from endogenous sources would circumvent many of the obstacles encountered by surgical restoration of beta cell mass via islet transplantation. Regeneration may occur both by beta cell self-duplication and by neogenesis from non-beta cell sources. Although the mechanisms regulating the beta cell replication pathway have been highly investigated, the signals that regulate beta cell neogenesis are relatively unknown. In this dissertation, I have used zebrafish as a genetic model system to investigate the process of beta cell neogenesis following insulin signaling depletion by various modes. Specifically, I have found that after their ablation, beta cells primarily regenerate from two discrete cellular sources: differentiation from uncommitted pancreatic progenitors and transdifferentiation from alpha cells. Importantly, I have found that insulin and glucagon play crucial roles in controlling beta cell regeneration from both sources. As with metabolic regulation, insulin and glucagon play counter-balancing roles in directing endocrine cell fate specification. These studies have revealed that glucagon signaling promotes beta cell formation by increasing differentiation of pancreas progenitors and by destabilizing alpha cell identity to promote alpha to beta cell transdifferentiation. In contrast, insulin signaling maintains pancreatic progenitors in an undifferentiated state and stabilizes alpha cell identity. Finally, I have shown that insulin also regulates pancreatic exocrine cell development. Insufficient insulin signaling destabilized acinar cell fate and impairs exocrine pancreas development. By understanding the roles of pancreatic hormones during pancreas development and regeneration can provide new therapeutic targets for in vivo beta cell regeneration to remediate the devastating consequences of diabetes.
Pancreatic Stem Cells
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Author : Juan Domínguez-Bendala
language : en
Publisher: Humana Press
Release Date : 2010-11-16
Pancreatic Stem Cells written by Juan Domínguez-Bendala and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Science categories.
From the discovery of Pdx1, the first “master gene” of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.
Molecular And Cell Biology Of Pancreas Development Function And Regeneration
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Author : Maria L. Golson
language : en
Publisher: Springer
Release Date : 2024-09-26
Molecular And Cell Biology Of Pancreas Development Function And Regeneration written by Maria L. Golson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-26 with Science categories.
This book reviews recent advances in pancreatic endocrine and exocrine tissue development, function and regeneration. It provides a comprehensive overview on different aspects of beta-cell biology, including heterogeneity of function and gene expression and function, epigenetics, RNA and protein expression contributions to beta-cell specification and cell-fate maintenance. Furthermore, it covers recent progress in differentiating functional islets in vivo, environmental impacts on beta-cell development and function, and communications between various islet endocrine cells and how they contribute to the regulation of blood glucose homeostasis. The book provides a comprehensive resource for understanding the various compartments of the pancreas and is aimed at pancreas, beta-cell biology, and diabetes researchers.
Budgeting And Financial Control 1997 175 S
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Author :
language : en
Publisher:
Release Date : 1997
Budgeting And Financial Control 1997 175 S written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.