Joint Models For Longitudinal And Time To Event Data

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Longitudinal Data Analysis

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Author : Garrett Fitzmaurice
language : en
Publisher: CRC Press
Release Date : 2008-08-11

Longitudinal Data Analysis written by Garrett Fitzmaurice and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-11 with Mathematics categories.

Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory

Handbook Of Statistical Methods For Randomized Controlled Trials

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Author : KyungMann Kim
language : en
Publisher: CRC Press
Release Date : 2021-08-23

Handbook Of Statistical Methods For Randomized Controlled Trials written by KyungMann Kim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-23 with Mathematics categories.

Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning, monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing, subgroup analysis, competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials, analysis of safety outcomes, non-inferiority trials, incorporating historical data, and validation of surrogate outcomes.

Advanced Survival Models

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Author : Catherine Legrand
language : en
Publisher: CRC Press
Release Date : 2021-03-22

Advanced Survival Models written by Catherine Legrand and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Mathematics categories.

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.

Bayesian Survival Analysis

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Author : Joseph G. Ibrahim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Bayesian Survival Analysis written by Joseph G. Ibrahim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

Survival analysis arises in many fields of study including medicine, biology, engineering, public health, epidemiology, and economics. This book provides a comprehensive treatment of Bayesian survival analysis. Several topics are addressed, including parametric models, semiparametric models based on prior processes, proportional and non-proportional hazards models, frailty models, cure rate models, model selection and comparison, joint models for longitudinal and survival data, models with time varying covariates, missing covariate data, design and monitoring of clinical trials, accelerated failure time models, models for mulitivariate survival data, and special types of hierarchial survival models. Also various censoring schemes are examined including right and interval censored data. Several additional topics are discussed, including noninformative and informative prior specificiations, computing posterior qualities of interest, Bayesian hypothesis testing, variable selection, model selection with nonnested models, model checking techniques using Bayesian diagnostic methods, and Markov chain Monte Carlo (MCMC) algorithms for sampling from the posteiror and predictive distributions. The book presents a balance between theory and applications, and for each class of models discussed, detailed examples and analyses from case studies are presented whenever possible. The applications are all essentially from the health sciences, including cancer, AIDS, and the environment. The book is intended as a graduate textbook or a reference book for a one semester course at the advanced masters or Ph.D. level. This book would be most suitable for second or third year graduate students in statistics or biostatistics. It would also serve as a useful reference book for applied or theoretical researchers as well as practitioners.

Joint Modeling Of Longitudinal And Time To Event Data

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Author : Robert Elashoff
language : en
Publisher: CRC Press
Release Date : 2016-10-04

Joint Modeling Of Longitudinal And Time To Event Data written by Robert Elashoff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-04 with Mathematics categories.

Longitudinal studies often incur several problems that challenge standard statistical methods for data analysis. These problems include non-ignorable missing data in longitudinal measurements of one or more response variables, informative observation times of longitudinal data, and survival analysis with intermittently measured time-dependent covariates that are subject to measurement error and/or substantial biological variation. Joint modeling of longitudinal and time-to-event data has emerged as a novel approach to handle these issues. Joint Modeling of Longitudinal and Time-to-Event Data provides a systematic introduction and review of state-of-the-art statistical methodology in this active research field. The methods are illustrated by real data examples from a wide range of clinical research topics. A collection of data sets and software for practical implementation of the joint modeling methodologies are available through the book website. This book serves as a reference book for scientific investigators who need to analyze longitudinal and/or survival data, as well as researchers developing methodology in this field. It may also be used as a textbook for a graduate level course in biostatistics or statistics.

Joint Models For Longitudinal And Time To Event Data

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Author : Dimitris Rizopoulos
language : en
Publisher: CRC Press
Release Date : 2012-06-22

Joint Models For Longitudinal And Time To Event Data written by Dimitris Rizopoulos and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-22 with Mathematics categories.

In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: Wit

Analysis Of Longitudinal Data

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Author : Peter Diggle
language : en
Publisher: Oxford University Press, USA
Release Date : 2013-03-14

Analysis Of Longitudinal Data written by Peter Diggle and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Language Arts & Disciplines categories.

This second edition has been completely revised and expanded to become the most up-to-date and thorough professional reference text in this fast-moving area of biostatistics. It contains an additional two chapters on fully parametric models for discrete repeated measures data and statistical models for time-dependent predictors.

Event History Analysis

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Author : Paul David Allison
language : en
Publisher: SAGE
Release Date : 1984-11

Event History Analysis written by Paul David Allison and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-11 with History categories.

Drawing on recent "event history" analytical methods from biostatistics, engineering, and sociology, this clear and comprehensive monograph explains how longitudinal data can be used to study the causes of deaths, crimes, wars, and many other human events. Allison shows why ordinary multiple regression is not suited to analyze event history data, and demonstrates how innovative regression - like methods can overcome this problem. He then discusses the particular new methods that social scientists should find useful.

Applied Longitudinal Data Analysis

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Author : Judith D. Singer
language : en
Publisher: Oxford University Press
Release Date : 2003-03-27

Applied Longitudinal Data Analysis written by Judith D. Singer and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-27 with Mathematics categories.

By charting changes over time and investigating whether and when events occur, researchers reveal the temporal rhythms of our lives.

Foundations Of Linear And Generalized Linear Models

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Author : Alan Agresti
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-23

Foundations Of Linear And Generalized Linear Models written by Alan Agresti and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-23 with Mathematics categories.

A valuable overview of the most important ideas and results in statistical modeling Written by a highly-experienced author, Foundations of Linear and Generalized Linear Models is a clear and comprehensive guide to the key concepts and results of linearstatistical models. The book presents a broad, in-depth overview of the most commonly usedstatistical models by discussing the theory underlying the models, R software applications,and examples with crafted models to elucidate key ideas and promote practical modelbuilding. The book begins by illustrating the fundamentals of linear models, such as how the model-fitting projects the data onto a model vector subspace and how orthogonal decompositions of the data yield information about the effects of explanatory variables. Subsequently, the book covers the most popular generalized linear models, which include binomial and multinomial logistic regression for categorical data, and Poisson and negative binomial loglinear models for count data. Focusing on the theoretical underpinnings of these models, Foundations ofLinear and Generalized Linear Models also features: An introduction to quasi-likelihood methods that require weaker distributional assumptions, such as generalized estimating equation methods An overview of linear mixed models and generalized linear mixed models with random effects for clustered correlated data, Bayesian modeling, and extensions to handle problematic cases such as high dimensional problems Numerous examples that use R software for all text data analyses More than 400 exercises for readers to practice and extend the theory, methods, and data analysis A supplementary website with datasets for the examples and exercises An invaluable textbook for upper-undergraduate and graduate-level students in statistics and biostatistics courses, Foundations of Linear and Generalized Linear Models is also an excellent reference for practicing statisticians and biostatisticians, as well as anyone who is interested in learning about the most important statistical models for analyzing data.