Joint Replacement And Bone Resorption
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Joint Replacement And Bone Resorption
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Author : Arun Shanbhag
language : en
Publisher: CRC Press
Release Date : 2005-11-09
Joint Replacement And Bone Resorption written by Arun Shanbhag and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-09 with Medical categories.
This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.
Joint Replacement And Bone Resorption
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Author : Arun Shanbhag
language : en
Publisher: CRC Press
Release Date : 2019-08-30
Joint Replacement And Bone Resorption written by Arun Shanbhag and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
This first guide devoted to this burgeoning topic, this authoritative reference presents the current understanding of the phenomenon of aseptic loosening of total joint replacements from the molecular and cellular mechanisms of periprosthetic bone loss to the clinical presentation and management strategies-reviewing the properties of ceramic, metal, and polymer materials used in the replacement of joints, as well as current research on bone remodeling, wear resistance, the long-term care of implants, and emerging developments in gene therapy and tissue engineering.
Joint Arthroplasty
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Author : Shinichi Imura
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Joint Arthroplasty written by Shinichi Imura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The introduction of total joint arthroplasty throughout the world has contributed manifold benefits to patients who suffer from joint diseases. Concurrently, however, there has been an increase in revision surgery. Many orthopedic surgeons agree that durability of prostheses is an eternal problem. In particular, periprosthetic osteolysis recently has been identified as one of the serious problems affecting prosthetic dura bility. To improve durability, osteolysis and many other problems must be investi gated and solved both experimentally and clinically with respect to such aspects as prosthetic material, design, and biological and biomechanical behavior. This book comprises 37 papers that were presented by orthopedic surgeons and biomedical engineers at the 28th Annual Meeting of the Japanese Society for Replace ment Arthroplasty, held in March 1998 in Kanazawa, Japan. The volume is thus a compilation of the latest knowledge about the pathogenesis and reduction of osteolysis and wear, newly developed total hip prostheses, and other current topics of total knee arthroplasty. We earnestly hope that this book will be of benefit to clinicians and researchers, and that it will contribute to the creation of more durable total joint prostheses in the future. SHINICHI IMURA v Contents Preface .................... '" .. .. .. ... . .. .. .. . ... .. . . .. . ... . . .. . V List of Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XI . . . . . . . . . . . . Part 1 Wear and Pathogenesis of Osteolysis Friction and Wear of Artificial Joints: A Historical Review N. AKAMATSU ................................................ , 3 Matrix Degradation in Osteoclastic Bone Resorption Under Pathological Conditions .
Advances In Bone Resorption Research And Treatment 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Advances In Bone Resorption Research And Treatment 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Advances in Bone Resorption Research and Treatment / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Resorption in a concise format. The editors have built Advances in Bone Resorption Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Resorption in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bone Resorption Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Imaging Of Prosthetic Joints
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Author : Carlina V. Albanese
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22
Imaging Of Prosthetic Joints written by Carlina V. Albanese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Medical categories.
An increasing percentage of the population has at least one prosthetic joint. Imaging is required for both initial assessment and routine follow-up of the implant, and this book is intended as an informative and up-to-date guide to the subject. After an introductory section covering a range of background topics, the level of information offered by different imaging techniques in presurgical planning and postimplantation assessment is analyzed. The application of imaging to different joints is then carefully explored in chapters devoted to the foot and ankle, hip, knee, shoulder, and elbow, wrist and hand. In addition, two innovative chapters focus on periprosthetic DXA as the gold standard in monitoring implant survival and on the role of drug therapy in helping to ensure the durability of the prosthesis. A central feature of the book is its combination of the clinical and radiological perspectives; it will be of value to radiologists and orthopedic specialists, as well as residents in these disciplines.
Aseptic Loosening Of Orthopedic Implants
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Author : Mehdi Amirhosseini
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-05-24
Aseptic Loosening Of Orthopedic Implants written by Mehdi Amirhosseini and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-24 with categories.
Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. Most studies on mechanisms for aseptic loosening investigate wear debris particle-induced osteolysis. However, pathological loading conditions around unstable implants can also trigger osteoclast differentiation and bone loss. In the first study, global gene expression changes induced by mechanical instability of implants, and by titanium particles were compared in a validated rat model for aseptic loosening. Microarray analysis showed that similar signaling pathways and gene expression patterns are involved in particle- and instability-induced periprosthetic osteolysis with an early onset innate immune response as a hallmark of osteolysis induced by mechanical instability. Further, effects of potential therapeutics on restriction of excessive osteoclast differentiation were evaluated. Wnt signaling pathway is known to regulate bone remodeling. In the second study, effects of inactivation of glycogen synthase kinase 3 beta (GSK-3?), a negative regulator of canonical Wnt signaling, on instability-induced periprosthetic osteolysis were examined using our rat model for aseptic loosening. Inhibition of GSK-3? led to a decrease in osteoclast numbers in the periprosthetic bone tissue exposed to mechanical instability while osteoblast perimeter showed an increase. This was accompanied by higher bone volume fraction (BV/TV) in animals treated with the GSK-3? inhibitor. In the third study, potential beneficial effects of two selective inhibitors of cyclindependent kinase 8/19 (CDK8/19) on bone tissue were evaluated. CDK8/19 is a Mediator complex-associated transcriptional regulator involved in several signaling pathways. CDK8/19 inhibitors, mainly under investigation as treatments for tumors, are reported to enhance osteoblast differentiation and bone formation. We show in this study, for the first time, that inhibition of CDK8/19 led to marked suppression of osteoclast differentiation from bone marrow macrophages in vitro through disruption of the RANK signaling. In mouse primary osteoblasts downregulation of osteopontin mRNA, a negative regulator of mineralization, together with increased alkaline phosphatase activity and calcium deposition indicated that osteoblast mineralization was promoted by CDK8/19 inhibition. Moreover, local administration of a CDK8/19 inhibitor promoted cancellous bone regeneration in a rat model for bone healing. These studies contribute to better understanding of mechanisms behind mechanical instability-induced periprosthetic osteolysis and propose potential therapeutics to restrict bone loss with effects on both osteoclasts and osteoblasts.
Revision Hip Arthroplasty
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Author : Richard N. Villar
language : en
Publisher: CRC Press
Release Date : 1997-01-16
Revision Hip Arthroplasty written by Richard N. Villar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-16 with Medical categories.
This publication will give clear advice to orthopaedic surgeons on the most up-to-date methods of revising artificial joints when there is bone stock loss. It aims to give a practical overview of the revision arthroplasty of the hip dealing not only with problems that may be dealt with by the community orthopaedic surgeons, but also those more likely to be referred to orthopaedic surgeons specialising in the area of revision arthroplasty. This practical guide and accessible reference text gives an overall picture of the present status of the resources that are available. Though more than 500,000 total hip replacements are performed worldwide each year, their eventual failure is becoming an ever-increasing problem. This comprehensive book gives clear advice on the most up-to-date method of revision surgery for failed hip prostheses, with emphasis on the management of bone stock loss. Chapters cover the whole spectrum of revision hip arthroplasty of the hip ranging from diagnosis and management of infection to tissue banking, femoral reconstruction, impaction grafting, and acetabular revision. Revision Hip Arthroplasty is essential reading for orthopaedic surgeons of all grades who undertake hip replacement surgery, and for those who wish to accept the more challenging complex cases. Rheumatologists, rehabilitation specialists and physiotherapists will also find this to be an invaluable source of information.
Implant Bone Interface
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Author : John Older
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Implant Bone Interface written by John Older and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
An update on current knowledge is given for surgeons and researchers involved in implant surgery and the development of implant arthroplasty. The contributions come from a distinguished international faculty of orthopaedic surgeons, biologists and engineers. They examine the junctional tissues between an implant and the bone in joint replacement surgery. The factors that influence junctional tissues and so affect the life-span of the implant are thoroughly discussed. These include: detailed data on the microscopy of the junctional tissues, the mechanical properties of cement, and the architecture of bone and implant design. The discussions following each contribution give meaningful insight into background information and the controversial aspects of surgical implants.
Biological Material And Mechanical Considerations Of Joint Replacement
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Author : Bernard F. Morrey
language : en
Publisher: Raven Press (ID)
Release Date : 1993
Biological Material And Mechanical Considerations Of Joint Replacement written by Bernard F. Morrey and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Artificial joints categories.
Vanishing Bone
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Author : William H. Harris
language : en
Publisher: Oxford University Press
Release Date : 2018
Vanishing Bone written by William H. Harris and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as periprosthetic osteolysis, this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone: Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation.