Label Free Biosensing Using Photonic Crystal Waveguides

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Label Free Biosensing Using Photonic Crystal Waveguides

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Author : Jaime García-Rupérez
language : en
Publisher:
Release Date : 2012

Label Free Biosensing Using Photonic Crystal Waveguides written by Jaime García-Rupérez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Advancing The Biosensing Technologies Of Two Optical Label Free Sensing Platforms

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Author : Rashmi Sriram
language : en
Publisher:
Release Date : 2015

Advancing The Biosensing Technologies Of Two Optical Label Free Sensing Platforms written by Rashmi Sriram and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

"Optical label-free biosensors promise high-throughput, rapid, and sensitive detection of biomolecules. As such, these biodetection platforms have applications in clinical diagnostics, pharmaceutical industry, homeland security and in environmental monitoring. Motivated by these attributes, my thesis has focused on advancing the biosensing technology of two novel silicon-based optical label-free sensors: arrayed imaging reflectometry (AIR) and two-dimensional photonic crystal structures (2D PhC). The AIR biosensor is an interferometry-based technique that relies on the creation and destruction of a near-zero reflectivity condition in a carefully chosen thin film. To thoroughly quantify the biosensor detection signal, a correlation between the sensor response and the solution analyte concentration needs to be determined. In the first half of this thesis, a theoretical framework was developed to predict the AIR sensor response for a given solution analyte concentration. The developed model was subsequently validated using spectroscopic ellipsometry and surface plasmon resonance techniques in addition to AIR by utilizing two model probe-analyte pairs. It was established that the probe-analyte interaction on AIR substrate across two formats: macrospots and microarrays closely represented one-site and two-site Langmuir models, respectively. Two-dimensional photonic crystals are periodic dielectric structures with spatial periodicity in two dimensions. In the presence of a "defect" microcavity that disrupts the spatial periodicity, light of specific wavelength can be captured within the defect cavity. This manifests as a "dip" in the transmission spectrum of the crystal and is very sensitive to the local refractive index changes in the immediate vicinity of the defect cavity. The second half of this thesis investigates the utility of two designs of the 2D PhC: "small" and "large" point-defect microcavities coupled to a transmission waveguide for sensing latex particles in microfluidic environment. With the "small" defect design, detection of ~100 nm size latex particles in microfluidic environment was confirmed. This is the first study that demonstrates particle detection in the presence of a fluid cover using a 2D PhC sensor, a significant technological advancement for the incorporation of this sensor into lab-on-a-chip device. Using a "large" point-defect cavity design, real-time detection of latex particles of size ~280 nm was demonstrated. This to our knowledge is the first demonstration of detection of latex particles in real-time using 2D PhCs without the aid of any optical forces. This proof-of-principle demonstration of particle detection lays the foundation for the further development of these devices for the detection of a single biological particle, which when accomplished will have a huge impact in the field of clinical diagnostics"--Pages ix-x.

Photonic Crystals

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Author : Alessandro Massaro
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-30

Photonic Crystals written by Alessandro Massaro and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-30 with Technology & Engineering categories.

The second volume of the book concerns the characterization approach of photonic crystals, photonic crystal lasers, photonic crystal waveguides and plasmonics including the introduction of innovative systems and materials. Photonic crystal materials promises to enable all-optical computer circuits and could also be used to make ultra low-power light sources. Researchers have studied lasers from microscopic cavities in photonic crystals that act as reflectors to intensify the collisions between photons and atoms that lead to lazing, but these lasers have been optically-pumped, meaning they are driven by other lasers. Moreover, the physical principles behind the phenomenon of slow light in photonic crystal waveguides, as well as their practical limitations, are discussed. This includes the nature of slow light propagation, its bandwidth limitation, coupling of modes and particular kind terminating photonic crystals with metal surfaces allowing to propagate in surface plasmon-polariton waves. The goal of the second volume is to provide an overview about the listed issues.

Development Of Photonic Crystal Biosensor For Label Free Bioassays

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Author : Syed Hussain
language : en
Publisher:
Release Date : 2011

Development Of Photonic Crystal Biosensor For Label Free Bioassays written by Syed Hussain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Biological assay categories.

Handbook Of Silicon Photonics

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Author : Laurent Vivien
language : en
Publisher: Taylor & Francis
Release Date : 2016-04-19

Handbook Of Silicon Photonics written by Laurent Vivien and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Science categories.

The development of integrated silicon photonic circuits has recently been driven by the Internet and the push for high bandwidth as well as the need to reduce power dissipation induced by high data-rate signal transmission. To reach these goals, efficient passive and active silicon photonic devices, including waveguide, modulators, photodetectors,

Photonic Materials For Sensing Biosensing And Display Devices

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Author : Michael J. Serpe
language : en
Publisher: Springer
Release Date : 2015-12-28

Photonic Materials For Sensing Biosensing And Display Devices written by Michael J. Serpe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-28 with Technology & Engineering categories.

This book presents the basics and applications of photonic materials. It focuses on the utility of these devices for sensing, biosensing, and displays. The book includes fundamental aspects with a particular focus on the application of photonic materials. The field of photonic materials is both a burgeoning, and mature field. There are new advances being made on a daily basis, all based on the fundamental roots set by work by those like Ozin, Thomas, Asher, and others.

Study And Development Of Label Free Optical Biosensors For Biomedical Applications

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Author : Charles J. Choi
language : en
Publisher:
Release Date : 2011

Study And Development Of Label Free Optical Biosensors For Biomedical Applications written by Charles J. Choi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

For the majority of assays currently performed, fluorescent or colorimetric chemical labels are commonly attached to the molecules under study so that they may be readily visualized. The methods of using labels to track biomolecular binding events are very sensitive and effective, and are employed as standardized assay protocol across research labs worldwide. However, using labels induces experimental uncertainties due to the effect of the label on molecular conformation, active binding sites, or inability to find an appropriate label that functions equivalently for all molecules in an experiment. Therefore, the ability to perform highly sensitive biochemical detection without the use of fluorescent labels would further simplify assay protocols and would provide quantitative kinetic data, while removing experimental artifacts from fluorescent quenching, shelf-life, and background fluorescence phenomena. In view of the advantages mentioned above, the study and development of optical label-free sensor technologies have been undertaken here. In general, label-free photonic crystal (PC) biosensors and metal nanodome array surface-enhanced Raman scattering (SERS) substrates, both of which are fabricated by nanoreplica molding process, have been used as the method to attack the problem. Chapter 1 shows the work on PC label-free biosensor incorporated microfluidic network for bioassay performance enhancement and kinetic reaction rate constant determination. Chapter 2 describes the work on theoretical and experimental comparison of label-free biosensing in microplate, microfluidic, and spot-based affinity capture assays. Chapter 3 shows the work on integration of PC biosensor with actuate-to-open valve microfluidic chip for pL-volume combinatorial mixing and screening application. In Chapter 4, the development and characterization of SERS nanodome array is shown. Lastly, Chapter 5 describes SERS nanodome sensor incorporated tubing for point-of-care monitoring of intravenous drugs and metabolites.

Computational Photonic Sensors

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Author : Mohamed Farhat O. Hameed
language : en
Publisher: Springer
Release Date : 2018-06-13

Computational Photonic Sensors written by Mohamed Farhat O. Hameed and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-13 with Technology & Engineering categories.

This book provides a comprehensive overview of the photonic sensing field by covering plasmonics, photonic crystal, and SOI techniques from theory to real sensing applications. A literature review of ultra-sensitive photonic sensors, including their design and application in industry, makes this a self-contained and comprehensive resource for different types of sensors, with high value to the biosensor sector in particular. The book is organized into four parts: Part I covers the basic theory of wave propagation, basic principles of sensing, surface plasmon resonance, and silicon photonics; Part II details the computational modeling techniques for the analysis and prediction of photonic sensors; Part III and Part IV cover the various mechanisms and light matter interaction scenarios behind the design of photonic sensors including photonic crystal fiber sensors and SOI sensors. This book is appropriate for academics and researchers specializing in photonic sensors; graduate students in the early and intermediate stages working in the areas of photonics, sensors, biophysics, and biomedical engineering; and to biomedical, environmental, and chemical engineers.

Tunable Photonic Crystal Biosensors For Portable Label Free Diagnostics

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Author : Meredith Marie Lee
language : en
Publisher:
Release Date : 2012

Tunable Photonic Crystal Biosensors For Portable Label Free Diagnostics written by Meredith Marie Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Although there is a pressing global need for widely-deployable disease detection and monitoring systems, today's options for biochemical analysis are often bulky, slow, expensive, and reliant on trained medical personnel. In contrast, the miniaturization and integration of devices based on arrays of sources, detectors, and active or passive biosensing surfaces provides a means to achieve handheld diagnostic capabilities with a "lab-on-a-chip" that would be vastly less expensive and fully automated. In this thesis, we design, fabricate, and characterize tunable biosensors with compact and low-cost Vertical Cavity Surface Emitting Lasers (VCSELs), integrated detectors, Peltier coolers, photonic crystal slab resonators, and polymer microfluidics. All of the components utilize scalable semiconductor and soft-lithography techniques to significantly reduce the required device footprint, simplify system assembly, and enable large-scale, economical manufacturing. The sensors operate in the visible to near-infrared 650-900 nm wavelength range for low absorption of water, hemoglobin, and other background elements found in tissue or aqueous samples. Moreover, the 670 nm label-free sensors we demonstrate are designed for compatibility with previously characterized monolithically integrated fluorimeters that capitalize on emerging deep-red fluorescent proteins and molecular probes approved for pre-clinical use by the Federal Drug Administration.

Label Free Biosensing

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Author : Michael J. Schöning
language : en
Publisher: Springer
Release Date : 2018-07-20

Label Free Biosensing written by Michael J. Schöning and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-20 with Science categories.

This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices