Lectures On Statistical Physics And Protein Folding
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Lectures On Statistical Physics And Protein Folding
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Author : Kerson Huang
language : en
Publisher: World Scientific
Release Date : 2005
Lectures On Statistical Physics And Protein Folding written by Kerson Huang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.
This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.
Protein Physics
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Author : Alexei V. Finkelstein
language : en
Publisher: Elsevier
Release Date : 2016-06-22
Protein Physics written by Alexei V. Finkelstein and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-22 with Science categories.
Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era
Aspects Of Physical Biology
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Author : Giancarlo Franzese
language : en
Publisher: Springer
Release Date : 2009-08-29
Aspects Of Physical Biology written by Giancarlo Franzese and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-29 with Science categories.
The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.
Statistical Mechanics Protein Structure And Protein Substrate Interactions
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Author : Sebastian Doniach
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22
Statistical Mechanics Protein Structure And Protein Substrate Interactions written by Sebastian Doniach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Science categories.
A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.
Statistical Physics Of Biomolecules
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Author : Daniel M. Zuckerman
language : en
Publisher: CRC Press
Release Date : 2010-06-02
Statistical Physics Of Biomolecules written by Daniel M. Zuckerman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-02 with Mathematics categories.
From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin
Statistical Mechanics Of Biocomplexity
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Author : D. Reguera
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-10-19
Statistical Mechanics Of Biocomplexity written by D. Reguera and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-19 with Science categories.
This book demonstrates the usefulness of tools from statistical mechanics for biology. It includes the new tendencies in topics like membranes, vesicles, microtubules, molecular motors, DNA, protein folding, phase transitions in biological systems, evolution, population dynamics, neural systems and biological oscillators, with special emphasis on the importance of statistical mechanics in their development. The book addresses researchers and graduate students.
Statistical Mechanics Protein Structure And Protein Substrate Interactions
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Author : Sebastian Doniach
language : en
Publisher:
Release Date : 2014-09-01
Statistical Mechanics Protein Structure And Protein Substrate Interactions written by Sebastian Doniach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with categories.
Mathematical Methods For Protein Structure Analysis And Design
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Author : Concettina Guerra
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-06-25
Mathematical Methods For Protein Structure Analysis And Design written by Concettina Guerra and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-25 with Mathematics categories.
The papers collected in this volume reproduce contributions by leading sch- arstoaninternationalschoolandworkshopwhichwasorganizedandheldwith thegoaloftakinga snapshotofadiscipline undertumultuous growth. Indeed, the area of protein folding, docking and alignment is developing in response to needs for a mix of heterogeneous expertise spanning biology, chemistry, mathematics, computer science, and statistics, among others. Some of the problems encountered in this area are not only important for the scienti?c challenges they pose, but also for the opportunities they disclose intermsofmedicalandindustrialexploitation. Atypicalexampleiso?eredby protein-drug interaction (docking), a problem posing daunting computational problems at the crossroads of geometry, physics and chemistry, and, at the same time, a problem with unimaginable implications for the pharmacopoeia of the future. The schoolfocused on problems posed by the study of the mechanisms - hind protein folding, and explored di?erent ways of attacking these problems under objective evaluations of the methods. Together with a relatively small core of consolidated knowledge and tools, important re?ections were brought to this e?ort by studies in a multitude of directions and approaches. It is obviously impossible to predict which, if any, among these techniques will prove completely successful, but it is precisely the implicit dialectic among them that best conveys the current ?avor of the ?eld. Such unique diversity and richness inspired the format of the meeting, and also explains the slight departure of the present volume from the typical format in this series: the exposition of the current sediment is complemented here by a selection of quali?ed specialized contributions.
Theory Of Phase Transitions In Polypeptides And Proteins
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Author : Alexander V. Yakubovich
language : en
Publisher: Springer
Release Date : 2011-09-02
Theory Of Phase Transitions In Polypeptides And Proteins written by Alexander V. Yakubovich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Science categories.
There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
Software Tools And Algorithms For Biological Systems
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Author : Hamid Arabnia
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-23
Software Tools And Algorithms For Biological Systems written by Hamid Arabnia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-23 with Science categories.
“Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP’09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.