Theory Of Phase Transitions In Polypeptides And Proteins
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Theory Of Phase Transitions In Polypeptides And Proteins
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Author : Alexander V. Yakubovich
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-01
Theory Of Phase Transitions In Polypeptides And Proteins written by Alexander V. Yakubovich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Science categories.
There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
Lectures On Statistical Physics And Protein Folding
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Author : Kerson Huang
language : en
Publisher: World Scientific
Release Date : 2005
Lectures On Statistical Physics And Protein Folding written by Kerson Huang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.
This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestion on possible research directions, as developed by the author in collaboration with C. C. Lin. The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes. The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.
Theory Of Helix Coil Transitions In Biopolymers
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Author : Douglas Poland
language : en
Publisher:
Release Date : 1970
Theory Of Helix Coil Transitions In Biopolymers written by Douglas Poland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Science categories.
Protein Physics
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Author : Alexei V. Finkelstein
language : en
Publisher: Elsevier
Release Date : 2016-06-22
Protein Physics written by Alexei V. Finkelstein and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-22 with Science categories.
Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era
Peptide And Protein Drug Analysis
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Author : Ronald Reid
language : en
Publisher: CRC Press
Release Date : 1999-11-12
Peptide And Protein Drug Analysis written by Ronald Reid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-12 with Medical categories.
Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.
Mathematical Physics
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Author : S Rahvar
language : en
Publisher: World Scientific
Release Date : 2005-05-09
Mathematical Physics written by S Rahvar and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-09 with Science categories.
Since 1984, a series of regional conferences on mathematical physics has been organized by physicists from Iran, Pakistan and Turkey to promote the research in mathematical and theoretical physics in the region. This volume, which derives from the XI Regional Conference on Mathematical Physics, comprises 8 review and 44 research articles on the most significant topics in mathematical and theoretical physics such as astrophysics and cosmology, conformal field theory, high energy physics, general relativity and plasma physics. The review articles are comprehensive and self-contained and report on the most important developments in the corresponding subjects. Each review article provides a complete list of references, which is especially useful for graduate students who are just starting their research activities; even ambitious undergraduates in physics can use these review papers as useful background material to go further into the subject and explore the research literature. They are contributed by prominent senior scientists: M Moniez (Laboratoire de l'Accelerateur Lineare, France) and V Sahni (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) in Astrophysics and Cosmology, W Nahm (Dublin Institute for Advanced Studies (DIAS), Ireland) in Conformal Field Theory, J Lukierski (University of Wroclaw, Poland) in Mathematical Physics, Riazuddin and Fayyazuddin (Quaid-i-Azam University, Pakistan) in High Energy Physics, N Dadhich (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) and A Qadir (National University of Science and Technology, Pakistan) in General Relativity, and N Tsintsadze (Tbilisi State University, Georgia) in Plasma Physics. Contents:Astrophysics and Cosmology:Does Transparent Hidden Matter Generate Optical Scintillation? (M Moniez)Galactic MACHO Budget: Problems and Possible Solution with the Abundant Brown Dwarfs (S Rahvar)The Mysterious Nature of Dark Energy (V Sahni)Condensed Matter and Statistical Physics:Two-Band Ginzburg-Landau Theory and Its Application to Recently Discovered Superconductors (I N Askerzade)Charge and Magnetization Plateaux in Strongly Correlated Systems (A Langari)Exactly Solvable Problems for Two-Dimensional Excitons (D G W Parfitt & M E Portnoi)High Energy Physics — Phenomenology:SUL(4) x U(1) Model for Electroweak Unification (Fayyazuddin)Some Remarks on Neutrino Mass Matrix (Riazuddin)General Relativity and Quantum Gravity:Probing Universality of Gravity (N Dadhich)Observing Black Holes (P De Paolis et al.)Constraint Algebra in Causal Loop Quantum Gravity (F Shojai & A Shojai)Mathematical Physics:Quantum Deformations of Relativistic Symmetries: Some Recent Developments (J Lukierski)Thermodynamics Bethe Ansatz (TBA) (W Nahm)Hidden Property of Extended Jordanian Twists for Lie Superalgebras (V N Tolstoy)Noncommutative Field Theory and String Theory:Exact Wilsonian Effective Superpotential for Noncommutative N = 1 Supersymmetric U(1) (F Ardalan & N Sadooghi)Aspects of Noncommutative Gauge Theories and Their Commutative Equivalents (R Banerjee)Plasma Physics:Relativistic Thermodynamics of the Strong Magnetized Dense Electron Plasma (N L Tsintsadze)and other papers Readership: Researchers in mathematical physics, theoretical physics, high energy physics, astrophysics, astronomy, cosmology and condensed matter physics. Keywords:Mathematical Physics;String Theory;Plasma Physics;CosmologyKey Features:Includes eight high quality review articles on various subjects in physics, such as astrophysics and cosmology, conformal field theory, mathematical physics, high energy physics, general relativity and plasma physics, contributed by prominent physicistsUseful for advanced graduate students and active researchers in physics
Statistical Thermodynamics Of Protein Folding
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Author : Ming-Hong Hao
language : en
Publisher:
Release Date : 1994
Statistical Thermodynamics Of Protein Folding written by Ming-Hong Hao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Protein folding categories.
Molecules And Life
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Author : Mikhail V. Vol kenshtein
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecules And Life written by Mikhail V. Vol kenshtein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
acids. The achievements of molecular biology testify to the success of material science in a realm which, until recently, appeared totally enig matic and mysterious. Further scientific developments should bring to mankind vast developments both in theoretical knowledge and in practical applications, namely, in agriculture, medicine, and technology. The purpose of this book is to explain molecular biophysics to all who might wish to learn about it, to biologists, to physicists, to chemists. This book contains descriptive sections, as well as sections devoted to rigorous mathematical treatment of a number of problems, some of which have been studied by the author and his collaborators. These sections may be omitted during a first reading. Each chapter has a selected bibliography. This book is far from an exhaustive treatise on molecular biophysics. It deals principally with questions related to the structures and functions of proteins and nucleic acids. M. V. Vol'kenshtein Leningrad, September, 1964 CONTENTS Chapter 1 Physics and Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Physics and Life. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Molecular Physics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Molecular Biophysics ................................... 9 Thermodynamics and Biology. . . . . . . . . . . . . . . . . . . . . 12 . . . . . . . Information Theory. . . . . . . . . . . . . . . . . . . . . . . . . . . 19 . . . . . . . . . . Chapter 2 Cells, Viruses, and Heredity. . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . The Living Cell. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . . . . Cell Division. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 . . . . . . . . . . . . Viruses and Bacteriophages ........... . . . . . . . . . . . . . . . 44 . . . . Basic Laws of Genetics . . . . . . . . . . . . . . . . . . . . . . . . . 50 . . . . . . . . . Mutations and Mutability ........ , ................. " . . . . 60 Genetics of Bacteria and Phages " . . . . . . . . . . . . . . . . . . 66 . . . . . . Chapter 3 Biological Molecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . . . Amino Acids and Proteins . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . Asymmetry of Biological Molecules ....................... 87 Primary Structure of Proteins ............................ 94 Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 . . . . . . . . . . . . Some Biochemical Processes in the Cell. . . . . . . . . . . . . . . . 109 . . . . Chapter 4 Physics of Macromolecules. . . . . . . . . . . . . . . . . . . . . . . . 123 . . . . . . . . .
Latest Advances In Atomic Cluster Collisions
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Author : J. P. Connerade
language : en
Publisher: Imperial College Press
Release Date : 2008
Latest Advances In Atomic Cluster Collisions written by J. P. Connerade and has been published by Imperial College Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
This book presents a ?snapshot? of the most recent and significant advances in the field of cluster physics. It is a comprehensive review based on contributions by the participants of the 2nd International Symposium on Atomic Cluster Collisions (ISACC 2007) held in July 19-23, 2007 at GSI, Darmstadt, Germany. The purpose of the Symposium is to promote the growth and exhange of scientific information on the structure and properties of nuclear, atomic, molecular, biological and complex cluster systems studied by means of photonic, electronic, heavy particle and atomic collisions. Particular attention is devoted to dynamic phenomena, many-body effects taking place in cluster systems of a different nature ? these include problems of fusion and fission, fragmentation, collective electron excitations, phase transitions, etc. Both the experimental and theoretical aspects of cluster physics, uniquely placed between nuclear physics on the one hand and atomic, molecular and solid state physics on the other, are discussed.
Computer Studies Of Phase Transitions And Critical Phenomena
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Author : Ole G. University of Southern Denmark
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Computer Studies Of Phase Transitions And Critical Phenomena written by Ole G. University of Southern Denmark and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book is based on research carried out by the author in close collabora tion with a number of colleagues. In particular, I wish to thank Per Bak, A. John Berlinsky, Hans C. Fogedby, Barry Frank, S. 1. Knak Jensen, David Mukamel, David Pink, and Martin Zuckermann for fruitful and extremely stimulating cooperation. It is a pleasure for me to note that active interaction with most of these colleagues is still continuing. The work has been performed at several different institutions, notably the Department of Chemistry, Aarhus University, Denmark, and the Depart ment of Physics, University of British Columb~a, Canada. I wish to thank the Department of Chemistry at Aarhus University for providing me with splen did research facilities over the years. From May 1980 to August 1981, I visited the Department of Physics at the University of British Columbia and I would like to express my sincere gratitude to members ofthe department for provi ding me with excellent working conditions. My special thanks are due to Professor Myer Bloom who introduced me to the field of phase transitions in biological membranes and in whose biomembrane group I found an extre mely stimulating scientific atmosphere happily married with a most agreeable social climate. During the last two years when a major part ofthis work was carried out, I was supported by AlS De Danske Spritfabrikker through their Jubilreumsle gat of 1981. Their support is gratefully acknowledged.