Theory Of Phase Transitions In Polypeptides And Proteins

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Theory Of Phase Transitions In Polypeptides And Proteins

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Author : Alexander V. Yakubovich
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-01

Theory Of Phase Transitions In Polypeptides And Proteins written by Alexander V. Yakubovich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Science categories.

There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.

Peptide And Protein Drug Analysis

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Author : Ronald Reid
language : en
Publisher: CRC Press
Release Date : 1999-11-12

Peptide And Protein Drug Analysis written by Ronald Reid and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-12 with Medical categories.

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

Mathematical Physics Proceedings Of The Xi Regional Conference

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Author : Sohrab Rahvar
language : en
Publisher: World Scientific
Release Date : 2005-05-09

Mathematical Physics Proceedings Of The Xi Regional Conference written by Sohrab Rahvar and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-09 with Science categories.

Since 1984, a series of regional conferences on mathematical physics has been organized by physicists from Iran, Pakistan and Turkey to promote the research in mathematical and theoretical physics in the region. This volume, which derives from the XI Regional Conference on Mathematical Physics, comprises 8 review and 44 research articles on the most significant topics in mathematical and theoretical physics such as astrophysics and cosmology, conformal field theory, high energy physics, general relativity and plasma physics.The review articles are comprehensive and self-contained and report on the most important developments in the corresponding subjects. Each review article provides a complete list of references, which is especially useful for graduate students who are just starting their research activities; even ambitious undergraduates in physics can use these review papers as useful background material to go further into the subject and explore the research literature. They are contributed by prominent senior scientists: M Moniez (Laboratoire de l'Accelerateur Lineare, France) and V Sahni (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) in Astrophysics and Cosmology, W Nahm (Dublin Institute for Advanced Studies (DIAS), Ireland) in Conformal Field Theory, J Lukierski (University of Wroclaw, Poland) in Mathematical Physics, Riazuddin and Fayyazuddin (Quaid-i-Azam University, Pakistan) in High Energy Physics, N Dadhich (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) and A Qadir (National University of Science and Technology, Pakistan) in General Relativity, and N Tsintsadze (Tbilisi State University, Georgia) in Plasma Physics.

Latest Advances In Atomic Cluster Collisions Structure And Dynamics From The Nuclear To The Biological Scale

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Author : Jean-patrick Connerade
language : en
Publisher: World Scientific
Release Date : 2008-09-10

Latest Advances In Atomic Cluster Collisions Structure And Dynamics From The Nuclear To The Biological Scale written by Jean-patrick Connerade and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-10 with Science categories.

This book presents a “snapshot” of the most recent and significant advances in the field of cluster physics. It is a comprehensive review based on contributions by the participants of the 2nd International Symposium on Atomic Cluster Collisions (ISACC 2007) held in July 19-23, 2007 at GSI, Darmstadt, Germany. The purpose of the Symposium is to promote the growth and exhange of scientific information on the structure and properties of nuclear, atomic, molecular, biological and complex cluster systems studied by means of photonic, electronic, heavy particle and atomic collisions. Particular attention is devoted to dynamic phenomena, many-body effects taking place in cluster systems of a different nature — these include problems of fusion and fission, fragmentation, collective electron excitations, phase transitions, etc. Both the experimental and theoretical aspects of cluster physics, uniquely placed between nuclear physics on the one hand and atomic, molecular and solid state physics on the other, are discussed./a

Molecular Biology Of Protein Folding Part A

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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2008-12-19

Molecular Biology Of Protein Folding Part A written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.

The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. Follow the new editor-in-chief, P. Michael Conn, as he introduces this first thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self Assembly Of Amyloidogenic Peptides

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Author : Jian-min Yuan
language : en
Publisher: World Scientific
Release Date : 2017-06-02

Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self Assembly Of Amyloidogenic Peptides written by Jian-min Yuan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-02 with Science categories.

This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.

Protein Folding Protocols

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Author : Yawen Bai
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04

Protein Folding Protocols written by Yawen Bai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.

Protein Folding Protocols presents protocols for studying and characterizing steps and conformational ensembles populating pathways in protein folding from the unfolded to the folded state. It further presents a sample of approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. Protein folding is a crucial step in the transfer of genetic information from the DNA to the protein. The Genome Project has led to a huge number of available DNA sequences and, therefore, protein sequences. The Structural Genomics initiative largely aims to obtain “new” folds not currently present in the Protein Data Bank. Yet, the number of available structures inevitably lags behind the number of sequences. At the same time, an equally important problem is to find out the types and scope of dissimilar (nonhomologous) protein sequences that adopt a similar fold. Assembling data and comprehension of the sequence space of protein folds should be very useful in computational protein structure prediction. This would enhance the scope of homology modeling, which currently is the method of choice. Thus, experimental and theoretical studies on the relationship between sequence and structure are critical. Figuring out the relationship between sequence and structure would further assist in the prediction of fibril structures observed in protein misfolding diseases, and in figuring out the conformational changes and dynamics resulting from mutations. Protein folding is one of the most important and challenging problems in current molecular and chemical biology.

Molecules And Life

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Author : Mikhail V. Vol kenshtein
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Molecules And Life written by Mikhail V. Vol kenshtein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

acids. The achievements of molecular biology testify to the success of material science in a realm which, until recently, appeared totally enig matic and mysterious. Further scientific developments should bring to mankind vast developments both in theoretical knowledge and in practical applications, namely, in agriculture, medicine, and technology. The purpose of this book is to explain molecular biophysics to all who might wish to learn about it, to biologists, to physicists, to chemists. This book contains descriptive sections, as well as sections devoted to rigorous mathematical treatment of a number of problems, some of which have been studied by the author and his collaborators. These sections may be omitted during a first reading. Each chapter has a selected bibliography. This book is far from an exhaustive treatise on molecular biophysics. It deals principally with questions related to the structures and functions of proteins and nucleic acids. M. V. Vol'kenshtein Leningrad, September, 1964 CONTENTS Chapter 1 Physics and Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Physics and Life. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Molecular Physics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Molecular Biophysics ................................... 9 Thermodynamics and Biology. . . . . . . . . . . . . . . . . . . . . 12 . . . . . . . Information Theory. . . . . . . . . . . . . . . . . . . . . . . . . . . 19 . . . . . . . . . . Chapter 2 Cells, Viruses, and Heredity. . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . The Living Cell. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . . . . Cell Division. . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . 37 . . . . . . . . . . . . Viruses and Bacteriophages ........... . . . . . . . . . . . . . . . 44 . . . . Basic Laws of Genetics . . . . . . . . . . . . . . . . . . . . . . . . . 50 . . . . . . . . . Mutations and Mutability ........ , ................. " . . . . 60 Genetics of Bacteria and Phages " . . . . . . . . . . . . . . . . . . 66 . . . . . . Chapter 3 Biological Molecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . . . Amino Acids and Proteins . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . Asymmetry of Biological Molecules ....................... 87 Primary Structure of Proteins ............................ 94 Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 . . . . . . . . . . . . Some Biochemical Processes in the Cell. . . . . . . . . . . . . . . . 109 . . . . Chapter 4 Physics of Macromolecules. . . . . . . . . . . . . . . . . . . . . . . . 123 . . . . . . . . .

The Physics Of Protein Structure And Dynamics

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Author : Reinhard Schweitzer-Stenner
language : en
Publisher: Elsevier
Release Date : 2024-09-23

The Physics Of Protein Structure And Dynamics written by Reinhard Schweitzer-Stenner and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-23 with Science categories.

The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses. - The readers will benefit from being provided with an in-depth overview of the physical concepts that govern different aspects of protein folding, disorder and self-assembly. By emphasizing the relationship between these issues, the approach adds a holistic character to the book - The book is to a major extent mathematically based. Mathematics is part of the language of physicists and physical chemists which cannot be properly substituted by words - For instructors, the book will offer a unique source for her/his teaching of current protein physics issues - The way how the book will be constructed (multiple references to primary literature with DOI links, literature-based problem sets and topics for discussion) will facilitate a learning process suitable for research-oriented students - Problem solving frequently requires the writing of short computer programs, something that is underemphasized in chemistry and biochemistry education (with the exception of computationally trained students, of course)

Fundamentals Of Neurodegeneration And Protein Misfolding Disorders

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Author : Martin Beckerman
language : en
Publisher: Springer
Release Date : 2015-11-06

Fundamentals Of Neurodegeneration And Protein Misfolding Disorders written by Martin Beckerman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-06 with Medical categories.

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.