Leukotrienes And Lipoxygenases
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Leukotrienes And Lipoxygenases
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Author : Joshua Rokach
language : en
Publisher: Elsevier Publishing Company
Release Date : 1989
Leukotrienes And Lipoxygenases written by Joshua Rokach and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Health & Fitness categories.
Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.
Lipoxygenases And Their Products
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Author : Stanley Crooke
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Lipoxygenases And Their Products written by Stanley Crooke and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.
Leukotrienes And Other Lipoxygenase Products
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Author : Bengt Samuelsson
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1982
Leukotrienes And Other Lipoxygenase Products written by Bengt Samuelsson and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Arachidonic acid categories.
Leukotrienes And Lipoxygenases
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Author : Joshua Rokach
language : en
Publisher:
Release Date : 1989
Leukotrienes And Lipoxygenases written by Joshua Rokach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Leukotrienes categories.
Drugs Affecting Leukotrienes And Lipoxygenase Products
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Author : I B C Business Publishing Limited
language : en
Publisher:
Release Date : 1988
Drugs Affecting Leukotrienes And Lipoxygenase Products written by I B C Business Publishing Limited and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Fatty acids categories.
Five Lipoxygenase Products In Asthma
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Author : Jeffrey Drazen
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Five Lipoxygenase Products In Asthma written by Jeffrey Drazen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products
Lipoxygenases In Inflammation
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Author : Dieter Steinhilber
language : en
Publisher: Springer
Release Date : 2016-04-27
Lipoxygenases In Inflammation written by Dieter Steinhilber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Medical categories.
Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.
Prostaglandins Leukotrienes And Lipoxins
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Author : J. Bailey
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prostaglandins Leukotrienes And Lipoxins written by J. Bailey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Leukotrienes
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Author : Ian Rodger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Leukotrienes written by Ian Rodger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.
Leukotrienes And Other Lipoxygenase Products
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Author : Royal College of Surgeons of England. Institute of Basic Medical Sciences. Symposium
language : en
Publisher: Research Studies Press Limited
Release Date : 1983-01-01
Leukotrienes And Other Lipoxygenase Products written by Royal College of Surgeons of England. Institute of Basic Medical Sciences. Symposium and has been published by Research Studies Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983-01-01 with Leukotrienes categories.