Leukotrienes

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Leukotrienes

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Author : Ian Rodger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Leukotrienes written by Ian Rodger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

In the two decades since the elusive "slow reacting substance of anaphylaxis" (SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.

Novel Inhibitors Of Leukotrienes

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Author : Giancarlo Folco
language : en
Publisher: Springer
Release Date : 2012-12-06

Novel Inhibitors Of Leukotrienes written by Giancarlo Folco and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.

The Leukotrienes

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Author : Lawrence Chakrin
language : en
Publisher: Elsevier
Release Date : 2012-12-02

The Leukotrienes written by Lawrence Chakrin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Nature categories.

The Leukotrienes, Chemistry and Biology discusses the significant scientific progress of leukotrienes, from the discovery of slow-reacting substance to the chemical identification of a mixture of leukotrienes. Composed of 11 chapters, the book presents an enormous increase in research on the chemistry and biology of these and related substances, especially as they relate to the etiology of allergic and inflammatory diseases. After briefly discussing the continuing perspectives on the leukotriene biology, the book describes the structure, synthesis, formation, and biological actions of leukotrienes. This is followed by a discussion on arachidonic metabolism for the development of therapeutic agents specifically designed to either inhibit the synthesis or antagonize the effects of the leukotrienes. The book also looks into the biochemical and pharmacologic control of the synthesis and actions of leukotrienes. The information is considered in the context of the specific enzymes in the pathway that may be affected by any given agent. The in vivo studies on the pulmonary mechanical effect of leukotrienes, the pharmacologic activity of leukotriene receptors, and the antagonistic property of peptidoleukotrienes as an approach to allergic disease treatment are considered in the concluding chapters of the book. This book will be of value to scientists and researchers interested in hypersensitivity reactions, inflammation, and allergic diseases.

Leukotrienes And Prostacyclin

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Author : F. Berti
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Leukotrienes And Prostacyclin written by F. Berti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The Leukotrienes

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Author : Priscilla J. Piper
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1986

The Leukotrienes written by Priscilla J. Piper and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

Leukotrienes And Prostanoids In Health And Disease

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Author : Zvi Naor
language : en
Publisher:
Release Date : 1986

Leukotrienes And Prostanoids In Health And Disease written by Zvi Naor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

Drugs Affecting Leukotrienes And Other Eicosanoid Pathways

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Author : G. Velo
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Drugs Affecting Leukotrienes And Other Eicosanoid Pathways written by G. Velo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Leukotrienes And Lipoxygenases

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Author : Joshua Rokach
language : en
Publisher: Elsevier Publishing Company
Release Date : 1989

Leukotrienes And Lipoxygenases written by Joshua Rokach and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Health & Fitness categories.

Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.

Leukotrienes In Cardiovascular And Pulmonary Function

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Author : Allan M. Lefer
language : en
Publisher:
Release Date : 1985

Leukotrienes In Cardiovascular And Pulmonary Function written by Allan M. Lefer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.

Prostaglandins Leukotrienes And The Immune Response

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Author : John L. Ninnemann
language : en
Publisher: Cambridge University Press
Release Date : 1988-09-30

Prostaglandins Leukotrienes And The Immune Response written by John L. Ninnemann and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-09-30 with Medical categories.

This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.