Links Between Recombination And Replication
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Links Between Recombination And Replication
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Author : Proceedings of the National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 2002-09-18
Links Between Recombination And Replication written by Proceedings of the National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-18 with Science categories.
There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.
Dna Replication Recombination And Repair
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Author : Fumio Hanaoka
language : en
Publisher: Springer
Release Date : 2016-01-22
Dna Replication Recombination And Repair written by Fumio Hanaoka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-22 with Science categories.
This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Molecular Structure Of Nucleic Acids
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Author :
language : en
Publisher: Ardent Media
Release Date : 1953
Molecular Structure Of Nucleic Acids written by and has been published by Ardent Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1953 with DNA. categories.
Dna Replication And Related Cellular Processes
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Author : Jelena Kusic-Tisma
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-26
Dna Replication And Related Cellular Processes written by Jelena Kusic-Tisma and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Medical categories.
Since the discovery of the DNA structure researchers have been highly interested in the molecular basis of genome inheritance. This book covers a wide range of aspects and issues related to the field of DNA replication. The association between genome replication, repair and recombination is also addressed, as well as summaries of recent work of the replication cycles of prokaryotic and eukaryotic viruses. The reader will gain an overview of our current understanding of DNA replication and related cellular processes, and useful resources for further reading.
Progress In Nucleic Acid Research And Molecular Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 1999-09-08
Progress In Nucleic Acid Research And Molecular Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-09-08 with Science categories.
- Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology - Features contributions from leaders in their fields - Contains abundant references
Yeast As A Tool In Cancer Research
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Author : John L Nitiss
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-16
Yeast As A Tool In Cancer Research written by John L Nitiss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-16 with Medical categories.
Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Biology Of Archea Volume 2
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Author : Béatrice Clouet-d'Orval
language : en
Publisher: John Wiley & Sons
Release Date : 2025-05-13
Biology Of Archea Volume 2 written by Béatrice Clouet-d'Orval and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Science categories.
Archaea constitute a new branch of life alongside bacteria and eukaryotes. These microorganisms are unique in their cellular and molecular aspects. They have evolutionary links with the first eukaryotic cells and are now being used to elucidate fundamental biological questions. Champions of extremophilicity, archaea are helping to lift the veil on the limits of life on Earth. Biology of Archaea 2 presents the diverse molecular mechanisms involved in the fundamental processes of genome maintenance and regulation of gene expression in archaeal cells. This book analyzes the complex machinery involved in chromosome replication, DNA repair, RNA synthesis (transcription) and protein synthesis (translation), and explores the different classes of RNAs and enzymes involved in RNA maturation and degradation. These regulate the stability of messenger and regulatory non-coding RNAs, and contribute to the formation of the mature forms of ribosomal RNAs and transfer RNAs. These molecular mechanisms are closely related to those of eukaryotes.
Dna Repair And Mutagenesis
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Author : Errol C. Friedberg
language : en
Publisher: American Society for Microbiology Press
Release Date : 2005-11-22
Dna Repair And Mutagenesis written by Errol C. Friedberg and has been published by American Society for Microbiology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-22 with Science categories.
An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Progress In Nucleic Acid Research And Molecular Biology
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Author : Kivie Moldave
language : en
Publisher: Elsevier
Release Date : 2003-11-19
Progress In Nucleic Acid Research And Molecular Biology written by Kivie Moldave and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-19 with Science categories.
This is a cumulative subject index for volumes 40-72 of Progress in Nucleic Acid Research and Molecular Biology. This series is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. - Cumulative subject index for volumes 40-72 of Progress in Nucleic Acid Research and Molecular Biology. - Brings to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.