Lipid Peroxidation In Biomembranes
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Lipid Peroxidation In Biomembranes
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Author : Valerian E. Kagan
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Lipid Peroxidation In Biomembranes written by Valerian E. Kagan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.
This book will explain the colossal potential of life to cope with different living environments is possible owing to the exceptionally well developed mechanisms of adaptation to environmental conditions. There is an innumerable variety of concrete mechanisms which make it possible for living creatures to adapt to different and changing environmental conditions. Nevertheless, all this variety is the manifestation of the three strategic line of the adaptation process: 1. Evolutional or genotypic adaptation. 2. Phenotypic adaptation. 3. Rapid adaptation.
Membrane Lipid Oxidation
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Author : Carmen Vigo-Pelfrey
language : en
Publisher: CRC-Press
Release Date : 1990-12-05
Membrane Lipid Oxidation written by Carmen Vigo-Pelfrey and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-12-05 with Science categories.
This two-volume text compiles the efforts of distinguished scientists nd focuses on the formation of free radicals, toxic effects of lipoperoxides, biological antioxidant protection against lipid peroxidation damage, and pathological implications of lipid peroxidation. This review also addresses vitamin E deficiency, carbon tetrachloride and ethanol poisoning, radiation damage, hyperbaric effects, tumors, aging, diabetes, liver degeneration, DNA damage, lipoprotein modification and artherosclerosis, multiple sclerosis, angiopathy, Parkinson's disease, lupus, and many other degenerative diseases. It is an excellent resource for biological chemist, cell biologists, and all who are interested in the pharmaceutical sciences.
Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes
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Author : Angel Catalá
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-17
Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes written by Angel Catalá and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-17 with Electronic book categories.
The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.
Free Radicals Lipoproteins And Membrane Lipids
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Author : A. Crastes de Paulet
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radicals Lipoproteins And Membrane Lipids written by A. Crastes de Paulet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book contains the proceedings of the ARW NATO Conference on "Action of Free Radicals and Active Forms of Oxygen on Lipoproteins and Membrane Lipids: Cellular Interactions and Atherogenesis", held in Bendor, France, October 5-8,1988. Since the pioneer work of Mc Cord and Fridovitch, growing interest has been focused on the study of the role of oxyradicals role in pathology. This interest is reflected in the exponential increase in the number of papers on free radicals, the success of specialized journals and books on this theme, and the organization of national and international meetings. These meetings have discussed, from.a broad point of view, the problems concerning the mechanisms of production of free radicals, their effects on cell CO!1$tituants (lipids, proteins, nucleic acids) and cell function, the methods of analysis of these phenomena, the pathological states in which free radicals may be involved, natural biological defense systems, and the design of "antiradical" therapies. But it is now well established that the most common target of oxy free radicals are membrane lipids because of their chemical nature (cholesterol in saturation, malonic linkage of polyunsaturated fatty acids (PUFA» and of their regular structural arrangement (monolayers in lipoproteins, bilayers in cell membranes). Thus the analysis of the products resulting from the action of oxy free radicals on PUFA is considered the best tool to indirectly evaluate the effects of tissue peroxidations, although the analytical basis for doing so is very questionable.
Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes
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Author :
language : en
Publisher:
Release Date : 2017
Impact Of Lipid Peroxidation On The Physiology And Pathophysiology Of Cell Membranes written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.
Reactive Oxygen Species Lipid Peroxidation And Protein Oxidation
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Author : Angel Catalá
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Reactive Oxygen Species Lipid Peroxidation And Protein Oxidation written by Angel Catalá and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Active oxygen categories.
Many studies have shown that free radical damage and lipid peroxidation increase as a function of the degree of unsaturation of the fatty acids present in the phospholipids of biological membranes. Membrane phospholipids are particularly susceptible to oxidation not only because of their highly polyunsaturated fatty acid content but also because of their association in the cell membrane with non-enzymatic and enzymatic systems capable of generating pro-oxidative-free radical species. There are two broad outcomes to lipid peroxidation: structural damage to membranes and generation of secondary products. Membrane damage derives from the generation of fragmented fatty acyl chains, lipidlipid cross-links, lipidprotein cross-links and endocyclisation to produce isoprostanes and neuroprostanes. These processes combine to produce changes in the biophysical properties of membranes that can have profound effects on the activity of membrane-bound proteins. The consequence of peroxidation of unsaturated fatty acids is severe: damage of membranes function, enzymatic inactivation, toxic effects on the cellular division, etc. This new book presents and discusses current research on oxidative stress, and lipid oxidation non-inhibited and inhibited; assessment of oxidative balance in the lipo- and hydro-philic cellular environment in biological systems; mass spectrometry detection of protein modification by cross-reaction with lipid peroxidation products; diagonal gel electrophoretic analysis of protein disulfides: principles and applications. Other chapters describe: heavy metals exposure and cells oxidative damage; biodegradation of metallic biomaterials: its relation with the generation of reactive oxygen species; Oxidative modifications of proteins in the aging heart; role of reactive oxygen species as signalling molecules involved in the regulation of physiological processes of the nervous system; oxidative stress in diabetes and hypertension treated with alternative therapy of medicinal plants; impairment of redox homeostasis of tissue damage in inborn errors of metabolism with intoxication: insights from human and animal studies and finally lipid peroxidation of phospholipids in the vertebrate retina or in liposomes made of retinal lipids: similarities and differences are described.
Lipid Peroxidation In Biological Systems
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Author : Alex Sevanian
language : en
Publisher: The American Oil Chemists Society
Release Date : 1988
Lipid Peroxidation In Biological Systems written by Alex Sevanian and has been published by The American Oil Chemists Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Science categories.
Free Radical Effects On Membranes
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-06-30
Free Radical Effects On Membranes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-30 with Science categories.
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. This volume consist of eleven chapters from experts in the field that encompass free-radical effects on diverse membrane functions, ranging from selective barrier functions, controlling membrane protein function to discussing how the hydrophobic environment within membranes regulate free radical reactivity. The focus is on articles discussing specific examples in which membranes from different cellular compartments (e.g. plasma, ER, mitochondria) and membrane proteins either regulate reactive species formation and reactivity or are specific targets of reactive species leading to alteration in function. * Provides overviews on biomembranes and the impact their physico-chemical properties have on reactive species reactivity * Focuses is on reactive species and control of cell-signaling pathways * Illustrates the concept that different reactive species can modulate function of specific membrane ion channels in different tissues, including sodium channels, chloride channels, sodium-potassium ATPases and calcium channels in both plasma and intracellular organelle membranes
Biomembranes Structural And Functional Aspects
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Author : Meir Shinitzky
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-11
Biomembranes Structural And Functional Aspects written by Meir Shinitzky and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-11 with Science categories.
An up-to date review of basic research on biomembranes. In thisvolume, foremost experts in the field consider the most importantstructural and functional aspects of biomembranes: - MembraneLipids and Aging - Membrane-bound Enzymes - Ion Channels in Biological Membranes - Anion Exchangers of Mammalian Cell Membranes - Diversity of Transport Mechanisms in Bacteria. The volume is an excellent supplement to 'Biomembranes - PhysicalAspects', also edited by Meir Shinitzky. Together these booksprovide a comprehensive ground for understanding complexphysiological processes. Meir Shinitzky, Ph.D., is a Professor of Biophysics in theDepartment of Membrane Research and Biophysics, The WeizmannInstitute of Science, Rehovot, Israel. Since 1971, his research hasfocused on various aspects of membrane structure and dynamics.Currently his main interest is in manipulation of membrane fluidityfor clinical diagnoses and treatments. He has published extensivelyand is acknowledged worldwide as one of the leading experts in theincreasingly significant field of biomembrane research.
Membrane Lipid Signaling In Aging And Age Related Disease
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Author : M.P. Mattson
language : en
Publisher: Elsevier
Release Date : 2003-05-06
Membrane Lipid Signaling In Aging And Age Related Disease written by M.P. Mattson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-06 with Science categories.
The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.