Lung Cancer Metastasis
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Lung Cancer Metastasis
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Author : Venkateshwar Keshamouni
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
Lung Cancer Metastasis written by Venkateshwar Keshamouni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.
Introduction To Cancer Metastasis
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Author : Aamir Ahmad
language : en
Publisher: Academic Press
Release Date : 2016-11-14
Introduction To Cancer Metastasis written by Aamir Ahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Science categories.
Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe
Lung Cancer Metastasis
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Author : Venkateshwar Keshamouni
language : en
Publisher: Springer
Release Date : 2009-10-29
Lung Cancer Metastasis written by Venkateshwar Keshamouni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-29 with Medical categories.
Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.
Lung Cancer Metastasis
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Author : Venkateshwar Keshamouni
language : en
Publisher: Springer
Release Date : 2009-09
Lung Cancer Metastasis written by Venkateshwar Keshamouni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09 with Electronic books categories.
Lung Metastases And Isolated Lung Perfusion
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Author : P. Van Schil
language : en
Publisher: Nova Publishers
Release Date : 2007
Lung Metastases And Isolated Lung Perfusion written by P. Van Schil and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Isolation perfusion (Physiology) categories.
Surgical resection of lung metastases is a widely accepted procedure but long-term results are disappointing with a 5-year survival rate of approximately 40%. The main prognostic factor is complete resection and a better survival is reported in patients with a single metastasis and a disease-free survival of more than 3 years. Re-operations are feasible but often patients become inoperable due to insufficient pulmonary reserve and new treatment modalities are looked for. Intravenous (iv) chemotherapy has no major impact on survival due to systemic side-effects when high doses are given. As isolated limb and liver perfusion, isolated lung perfusion (ILuP) has the advantage of selectively delivering an agent into the lung while diverting the venous effluent. This allows the drug to be given in a significantly higher dose compared to iv therapy, while drug levels in the other organs are kept low enough to avoid major complications. ILuP has been shown to be very effective for the treatment of lung metastases in animal models. Phase I clinical studies to determine dose-limiting toxicity and maximum tolerated dose have recently been reported. The principal aim of this book is to discuss the current treatment of lung metastases and the possible contribution of ILuP.
Pulmonary Metastasis
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Author : Leonard Weiss
language : en
Publisher: Macmillan Reference USA
Release Date : 1978
Pulmonary Metastasis written by Leonard Weiss and has been published by Macmillan Reference USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment
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Author : Lizza E.L Hendriks
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-21
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment written by Lizza E.L Hendriks and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-21 with categories.
Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.
Cancer Metastasis Through The Lymphovascular System
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Author : Stanley P. Leong
language : en
Publisher: Springer Nature
Release Date : 2022-06-24
Cancer Metastasis Through The Lymphovascular System written by Stanley P. Leong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
New Treatment Strategies In Metastatic Lung Cancer
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Author : Ramaswamy Govindan
language : en
Publisher: Cmp United Business Media
Release Date : 2008-01-01
New Treatment Strategies In Metastatic Lung Cancer written by Ramaswamy Govindan and has been published by Cmp United Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Lungs categories.
A textbook for oncologists discussing new treatment options for metastatic lung cancer.
Lung Cancer An Issue Of Radiologic Clinics Of North America E Book
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Author : Jeremy Erasmus
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-04-21
Lung Cancer An Issue Of Radiologic Clinics Of North America E Book written by Jeremy Erasmus and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-21 with Medical categories.
This issue of Radiologic Clinics of North America focuses on Imaging of Lung Cancer, and is edited by Drs. Jeremy Erasmus and Mylene T. Truong. Articles will include: Lung Cancer Biopsies; Lung Nodule Incidental: Management; Lung Nodule Screening: Management; Missed Lung Cancer; Update in MRI of Evaluation of Lung Cancer; Staging Lung Cancer: Tumor; Staging Lung Cancer: Node; Staging Lung Cancer: Metastasis; Dilemmas in Lung Cancer Staging; Biomarkers in Lung Cancer; Radiation Therapy in Lung Cancer; Chemo and Immunotherapy in Lung Cancer; and more!