Malaria Vaccines
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Malaria Vaccines
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Author : Irwin W Sherman
language : en
Publisher: World Scientific
Release Date : 2016-03-29
Malaria Vaccines written by Irwin W Sherman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-29 with Medical categories.
In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication. Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months. This book chronicles the development of RTS, S — done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation — as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development. This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders. Contents: The Three Lives of the Malaria ParasiteA Personal Scientific OdysseyTaming the Malaria ParasiteThe Quest for a Blood Stage Vaccine BeginsMalaria Vaccines and MalfeasanceDreaming of a Nobel PrizeMolecular Biology Assists in Vaccine DevelopmentDeveloping Vaccines Against Blood StagesPfEMP1, pfalhesin, and DBRVaccines to Halt TransmissionSporozoite Invasion and the Path to RTS, SAttenuated Plasmodial VaccinesViruses and Plasmodial VaccinesWhy the Quest Continues Readership: Graduate students, teachers, microbiologists, parasitologists, physicians, clinicians, funders of research and readers interested in the research area.
Malaria
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Author : Maria M. Mota
language : en
Publisher: Springer
Release Date : 2017-01-12
Malaria written by Maria M. Mota and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-12 with Medical categories.
Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term. Malaria: Immune Response to Infection and Vaccination provides a comprehensive view on the immune response to malaria and to the different vaccines under development. The book offers the following: - Contributions by top research leaders in the field, - Comparisons of the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately, - Coverage of the immune responses to the different stages of malaria, which are frequently treated as separate fields of research.
Molecular Immunological Considerations In Malaria Vaccine Development
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Author : Michael F. Good
language : en
Publisher: CRC Press
Release Date : 1993-10-13
Molecular Immunological Considerations In Malaria Vaccine Development written by Michael F. Good and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-10-13 with Medical categories.
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Battling Malaria
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-07-26
Battling Malaria written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-26 with Technology & Engineering categories.
Malaria is an infectious disease common to several parts of the world, including Africa, northern South America, and Asia. During their service in the military, U.S. active members may be sent to any part of the world, including parts of the world where Malaria is an issue. In Liberia in 2003, for example, there was a 28 percent attack rate in Marines who spent a short time ashore, and half of the 80 Marines affected needed to be evacuated to Germany. This was not only costly to the U.S. military but dangerous as well. To fight against this disease, there exists a Malaria Vaccine program in the U.S. military. However, there exists a variety of potential vaccine targets for the most severe and important form of malaria; malaria from the species Plasmodium falciparum. Issues also arise with the fact that there are three possible stages to create vaccines against-preerythrocytic, blood, or transmission. The Department of Defense (DoD), through the commanding general of the U.S. Army Medical Research and Materiel Command (USAMRMC), requested that the Institute of Medicine (IOM) conduct a programmatic review of the military Plasmodium falciparum malaria vaccine research and development program. There was to be a focus on vaccine against the preerythrocytic and blood stages. The IOM formed a committee of 11 experts with collective expertise in malaria vaccine research, parasite immunology, malarial biology, clinical trials and regulatory affairs, industrial and public-sector vaccine development, biologic products research and development (vaccinology), military research and development programs, tropical medicine, and public health. The committee focused different tasks including determining whether the DoD malaria vaccine research and development program is scientifically sound and able to achieve the vaccine program objectives within specified timelines, recommending how to overcome significant, identified barriers, and identifying major strategic goals and timelines based on the material received and presentations made by the DoD's program representatives. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program presents the committee's findings, current malaria vaccines, and recommendations for the development of the U.S. Military vaccine research.
Malaria
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Author : G. A. T. Targett
language : en
Publisher: John Wiley & Sons
Release Date : 1991
Malaria written by G. A. T. Targett and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Malaria Waiting for the Vaccine Edited by G.A.T. Targett, London School of Hygiene and Tropical Medicine Malaria affects enormous populations in tropical and sub-tropical areas of the world. In global terms,the situation is worsening as the impact of parasite and mosquito vector adaptations to drugs and insecticides exacerbates weaknesses in control programmes already under great strain for socio-economic reasons. This book, the first in a series of annual public health from the London School of Hygiene and Tropical Medicine, brings together expertise in all of the disciplines that impinge on current control efforts and that are essential for the development of new and improved measures. The ten sections provide a balance between the different approaches to public health management of malaria,those concerned with the individual who is infected, and control at community level. Clinical control emphasizes management of severe disease and the impact of drug resistance. Community public health measures consider all aspects of vector control, use and supply of drugs in endemic regions, and the organization and economics of control. For the future, the current status of vaccine development and the conduct of field trials are assessed. Detailed discussions amongst experts in each field lead to a series of recommendations designed to assist those currently engaged in control and management of the disease, to indicate priorities for future research, and above all to provide an agenda for national and international discussion on future strategies for combating the disease. The book will also appeal to epidemiologists, research scientists and clinicians as it sets their research and responsibilities in a much wider context than normal. In a similar way it will be invaluable for postgraduate teaching.
Malaria Immunology
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Author : Peter Perlmann
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2002-01-01
Malaria Immunology written by Peter Perlmann and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-01 with Medical categories.
Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Malaria Vaccines
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Author : Ashley M. Vaughan
language : en
Publisher:
Release Date : 2015
Malaria Vaccines written by Ashley M. Vaughan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Biomedicine categories.
This volume focuses on malaria vaccinology, and introduces researchers to a complete overview of the protocols and tools used by molecular and cellular malariologists. The chapters within the book talk about interventions concerning all aspects of life cycle progression - measuring antibody responses to blood stage parasite survival, the T Cell responses engendered by attenuated sporozoite vaccinations, and the unique effect on transmission of antibodies that target the mosquito stage of the life cycle. Additionally, methods concerning the ability to generate targeted gene deletions and replacements in the genome of Plasmodium parasites convey how Plasmodium parasite phenotypes can be created to precise specifications.
Vaccines Against Malaria
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Author : Committee on Malaria Vaccines
language : en
Publisher:
Release Date : 1996
Vaccines Against Malaria written by Committee on Malaria Vaccines and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
The Elusive Malaria Vaccine
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Author : Irwin W. Sherman
language : en
Publisher:
Release Date : 2009
The Elusive Malaria Vaccine written by Irwin W. Sherman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Chronicling a 100-year quest, this book tells the fascinating story of the hunt for the still-elusive malaria vaccine. Sherman captures the controversies, missteps, stolen ideas, and clashes of ego as researchers around the world compete to develop the first successful malaria vaccine.
Who Working Group On Late Stage Development For Malaria Vaccines To Reduce Disease Burden
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Author :
language : en
Publisher: World Health Organization
Release Date : 2022-05-17
Who Working Group On Late Stage Development For Malaria Vaccines To Reduce Disease Burden written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-17 with Medical categories.