The Elusive Malaria Vaccine
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The Elusive Malaria Vaccine
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Author : Irwin W. Sherman
language : en
Publisher:
Release Date : 2009
The Elusive Malaria Vaccine written by Irwin W. Sherman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Chronicling a 100-year quest, this book tells the fascinating story of the hunt for the still-elusive malaria vaccine. Sherman captures the controversies, missteps, stolen ideas, and clashes of ego as researchers around the world compete to develop the first successful malaria vaccine.
Malaria Vaccines
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Author : Irwin W Sherman
language : en
Publisher: World Scientific
Release Date : 2016-03-29
Malaria Vaccines written by Irwin W Sherman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-29 with Medical categories.
In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication. Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months. This book chronicles the development of RTS, S — done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation — as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development. This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders. Contents: The Three Lives of the Malaria ParasiteA Personal Scientific OdysseyTaming the Malaria ParasiteThe Quest for a Blood Stage Vaccine BeginsMalaria Vaccines and MalfeasanceDreaming of a Nobel PrizeMolecular Biology Assists in Vaccine DevelopmentDeveloping Vaccines Against Blood StagesPfEMP1, pfalhesin, and DBRVaccines to Halt TransmissionSporozoite Invasion and the Path to RTS, SAttenuated Plasmodial VaccinesViruses and Plasmodial VaccinesWhy the Quest Continues Readership: Graduate students, teachers, microbiologists, parasitologists, physicians, clinicians, funders of research and readers interested in the research area.
Battling Malaria
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-08-26
Battling Malaria written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-26 with Technology & Engineering categories.
Malaria is an infectious disease common to several parts of the world, including Africa, northern South America, and Asia. During their service in the military, U.S. active members may be sent to any part of the world, including parts of the world where Malaria is an issue. In Liberia in 2003, for example, there was a 28 percent attack rate in Marines who spent a short time ashore, and half of the 80 Marines affected needed to be evacuated to Germany. This was not only costly to the U.S. military but dangerous as well. To fight against this disease, there exists a Malaria Vaccine program in the U.S. military. However, there exists a variety of potential vaccine targets for the most severe and important form of malaria; malaria from the species Plasmodium falciparum. Issues also arise with the fact that there are three possible stages to create vaccines against-preerythrocytic, blood, or transmission. The Department of Defense (DoD), through the commanding general of the U.S. Army Medical Research and Materiel Command (USAMRMC), requested that the Institute of Medicine (IOM) conduct a programmatic review of the military Plasmodium falciparum malaria vaccine research and development program. There was to be a focus on vaccine against the preerythrocytic and blood stages. The IOM formed a committee of 11 experts with collective expertise in malaria vaccine research, parasite immunology, malarial biology, clinical trials and regulatory affairs, industrial and public-sector vaccine development, biologic products research and development (vaccinology), military research and development programs, tropical medicine, and public health. The committee focused different tasks including determining whether the DoD malaria vaccine research and development program is scientifically sound and able to achieve the vaccine program objectives within specified timelines, recommending how to overcome significant, identified barriers, and identifying major strategic goals and timelines based on the material received and presentations made by the DoD's program representatives. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program presents the committee's findings, current malaria vaccines, and recommendations for the development of the U.S. Military vaccine research.
Malaria
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Malaria written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Medical categories.
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
The Long Struggle Against Malaria In Tropical Africa
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Author : James L. A. Webb, Jr
language : en
Publisher: Cambridge University Press
Release Date : 2014-03-31
The Long Struggle Against Malaria In Tropical Africa written by James L. A. Webb, Jr and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-31 with History categories.
The first history of malaria control efforts in tropical Africa, contributing to the emerging sub-discipline of the historical epidemiology of contemporary disease challenges.
The Malaria Genome Projects
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Author : Irwin W Sherman
language : en
Publisher: World Scientific
Release Date : 2012-07-13
The Malaria Genome Projects written by Irwin W Sherman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-13 with Medical categories.
The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Projects came into being, the people who created them, and the cadre of scientists who are attempting to see the promise of the Projects realized. The promise was: a more complete understanding of the genes of the parasite (and its vector) would provide a rational basis for the development of antimalarial drugs and vaccines, allow a better understanding of the regulation of the complex life cycle in the red blood and liver cells of the human, identify the genes the parasite uses to thwart the host immune response and the ways in which the parasite evades cure by drug treatments, as well as leading to more effective measures of control transmission. The hope was that cracking the genetic code of Plasmodium and Anopheles would reveal the biochemical Achilles heel of the parasite and its vector, leading to the development of novel drugs and better methods of control, and by finding the targets of protective immunity could result in the manufacture of effective vaccines. Through a historic approach, this book will allow for those new to the field, or those with insufficient background in the sciences, to have an easier entry point. Even scientists already working in the field may better appreciate how discoveries made in the past can impact the direction of future research. Contents:IntroductionRespice: Before the Genome ProjectThe Nature of Plasmodium falciparum and Its GenomeChipping Away at the GenomeThe Importance of ImportRemodeling the Genome's HomeGetting on the InsideThe Great EscapeThe Neglected Malaria: Plasmodium vivaxThe Anopheles Genome and Transmission ControlThe Monkey's TaleA Not So Sweet SolutionTo Search and FindThe Elusive VaccinesNew Medicines, Old ProblemsProspice: Looking to the Future Readership: Biochemists, parasitologists, microbiologists, molecular geneticists, immunologists, hematologists, malariologists and tropical physicians and graduate students. Keywords:Malaria;Genome Project;Plasmodium falciparum;Anopheles;Host Immune Response;Parasite;Drugs and Vaccines
Disease Control Priorities Third Edition Volume 6
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Author : King K. Holmes
language : en
Publisher: World Bank Publications
Release Date : 2017-11-06
Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-06 with Medical categories.
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Infectious Diseases
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Author : Lester M Shulman
language : en
Publisher: Springer Nature
Release Date : 2023-02-07
Infectious Diseases written by Lester M Shulman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-07 with Medical categories.
This volume on Infectious Diseases in an Encyclopedia of Sustainability Science and Technology (ESST) addresses the needs of health care providers and policy makers as well as scientists and engineers. Most of chapters in this volume deal with infectious diseases that directly affect humans, including the detailed characterization of specific pathogens, how they reproduce, how they are transmitted, and the means available to control, eliminate, or eradicate them. In this revised and updated second edition, the number of human infectious diseases covered has been significantly expanded. Other new chapters deal with current leading edge technologies for the diagnosis of pathogens; surveillance including environmental and syndromic surveillance for pathogens; requirements for quality assurance, quality control and the need for biological standards and controls to sustain high quality diagnosis and surveillance; the use of big data for personalized medicine; modeling infectious diseases; zoonotic and vector borne diseases; disease prevention with antibiotics, antivirals and vaccines; and factors that affect ecological balances leading to emergence of new diseases such as climate change and deforestation. Finally, infectious diseases that affect livestock and culture of plants for food, comfort and beauty are also addressed, since we must also consider them when discussing sustainability of humans in our ecosystem.
Infectious Diseases
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Author : Phyllis Kanki
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-15
Infectious Diseases written by Phyllis Kanki and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-15 with Medical categories.
Infectious Diseases: Selected Entries from the Encyclopedia of Sustainability Science and Technology presents authoritative, peer-reviewed contributions from leading experts on a wide range of major infectious diseases of global importance. Infectious diseases account for more than 17 million deaths each year worldwide. While modern medicine and technology have diminished the threat of many of these pathogens in high-income countries, the ever present threats of re-emerging infections, population mobility, natural disasters, and pathogen genetic variability are but some of the reasons for the dynamic threat of this broad category of risks to human health. An indispensable resource for students and scientists, the volume also covers some of the new technologies currently under development for infectious disease prevention, treatment, and eradication. The greater part of the infectious disease burden remains in the tropics, where low and middle-income countries lack the resources, infrastructure, and health systems to mount or sustain control efforts. Many contributions describe the efforts of the scientific research community and international donor agencies to achieve the integrated goals of vigilant surveillance, improved and cost-effective diagnostics, and treatment for sustainable disease control.
Twelve Diseases That Changed Our World
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Author : Irwin W. Sherman
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-24
Twelve Diseases That Changed Our World written by Irwin W. Sherman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
Covers the history of twelve important diseases and addresses public health responses and societal upheavals. Chronicles the ways disease outbreaks shaped traditions and institutions of Western civilization. Explains the effects, causes, and outcomes from past epidemics. Describes a dozen diseases to show how disease control either was achieved or failed. Makes clear the interrelationship between diseases and history. Presents material in a compelling, clear, and jargon-free prose for a wide audience. Provides a picture of the best practices for dealing with disease outbreaks.