Mass Spectrometry Based Glycoproteomics And Its Clinic Application
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Mass Spectrometry Based Glycoproteomics And Its Clinic Application
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Author : Haojie Lu
language : en
Publisher: CRC Press
Release Date : 2021-09-20
Mass Spectrometry Based Glycoproteomics And Its Clinic Application written by Haojie Lu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-20 with Science categories.
As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry–Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.
Mass Spectrometry Based Glycoproteomics And Its Clinic Application
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Author : Haojie Lu
language : en
Publisher: CRC Press
Release Date : 2021-09-21
Mass Spectrometry Based Glycoproteomics And Its Clinic Application written by Haojie Lu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-21 with Science categories.
As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry–Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.
Separation Techniques In Analytical Chemistry
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Author : Rudolf Bock
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2023-07-24
Separation Techniques In Analytical Chemistry written by Rudolf Bock and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-24 with Science categories.
The separation of a mixture into its individual components is one of the most fundamental procedures in analytical and industrial chemistry. This classic book in analytical chemistry provides a comprehensive yet systematic outline of all known separation methods. Through its detailed treatment of the basic principles of separation possibilities, it not only covers what is currently known, but also represents a treasure trove of methods that are still awaiting further development. It is clearly structured and contains interesting examples, further reading and a detailed index. An indispensable book for advanced students of natural sciences (chemistry, biochemistry, food chemistry, pharmacy, clinical chemistry, environmental sciences) and technology (chemical engineering, chemical-physical measurement & biotechnology), as well as teachers of these disciplines.
Clinical Applications Of Mass Spectrometry
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Author :
language : en
Publisher:
Release Date : 2009
Clinical Applications Of Mass Spectrometry written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Development And Application Of Comparative Proteomics And Glycoproteomics Approaches Based On Liquid Phase Separation And Mass Spectrometry
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Author : Jia Zhao
language : en
Publisher:
Release Date : 2007
Development And Application Of Comparative Proteomics And Glycoproteomics Approaches Based On Liquid Phase Separation And Mass Spectrometry written by Jia Zhao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Mass Spectrometry Of Proteins And Peptides
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Author : Mary S. Lipton
language : en
Publisher: Humana Press
Release Date : 2008-11-01
Mass Spectrometry Of Proteins And Peptides written by Mary S. Lipton and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Science categories.
When the last edition of this book was published in 2000, the field of proteomics was in its infancy. At that time, multidimensional liquid chromatographic separations were being introduced as an alternative to traditional gel-based techniques for separating complex protein and peptide mixtures prior to mass spectrometric detection. Today, this approach – referred to as shotgun proteomics – is considered routine for lar- scale global analyses of protein mixtures. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. Much wider accessibility of hi- resolution and mass measurement accuracy instrumentation in recent years has ini- ated a new revolution in the field by providing more reliable data and shifting the focus from cataloging proteins to precisely quantifying changes in protein abundance over time and in response to stimuli. Advanced mass spectrometers and novel ion d- sociation schemes such as electron transfer/capture dissociation make it possible to venture boldly into the maze of protein posttranslational modifications, which are an integral component of understanding functional proteomics in the spatial and t- poral domains. Another area that has benefited from these advancements is top-down proteomics, an emerging method essential for characterizing various protein variants that has potentially high impact in biomedical research.
Clinical Proteomics
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Author : Antonia Vlahou
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-18
Clinical Proteomics written by Antonia Vlahou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-18 with Science categories.
In this book, a select group of researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. The book integrates biochemistry, pathology, analytical technology, bioinformatics, and proteome informatics. Experimental approaches are thoroughly detailed and explained through a step-by-step instructional format that ensures successful results.
Mass Spectrometry Of Glycoproteins
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Author : Jennifer J. Kohler
language : en
Publisher: Humana Press
Release Date : 2016-05-01
Mass Spectrometry Of Glycoproteins written by Jennifer J. Kohler and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with Science categories.
This comprehensive new resource in Springer s Methods in Molecular Biology series features contributions from leading researchers who provide expert advice and reproducible, cutting-edge protocols for examining glycoproteins through mass spectrometry."
Mass Spectrometry Based Proteomics
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Author : Kris Gevaert
language : en
Publisher: Springer Nature
Release Date : 2023-09-04
Mass Spectrometry Based Proteomics written by Kris Gevaert and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-04 with Science categories.
This detailed volume explores contemporary techniques in mass spectrometry-based proteomics. After covering overall proteome coverage and the cellular surfaceome, the book delves into proximity-induced biotinylation, abduction of protein complexes in viral-like particles, and thermal proteome profiling, as well as protocols for identifying protein N-terminal acetylation, protein processing by proteases, protein N-glycosylation, and protein phosphorylation. The book also collects chapters on automated preparation of clinical samples, the analysis of formalin-fixed paraffin-embedded samples, protocols for the isolation of extracellular vesicles and for the monitoring of selected protein modifications in clinical samples, and, finally, structural proteomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry-Based Proteomics serves as an ideal guide to its subject for both novices in the field of proteomics as well as specialists.
Clinical Applications Of Mass Spectrometry In Biomolecular Analysis
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Author : Uttam Garg
language : en
Publisher: Humana
Release Date : 2023-10-05
Clinical Applications Of Mass Spectrometry In Biomolecular Analysis written by Uttam Garg and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-05 with Science categories.
This updated volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and limited need for specialized reagents. These techniques are essential in laboratory fields including endocrinology, biochemical genetics, drug analysis, proteomics, and pathogen identification. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols, Second Edition is an ideal resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.