Mass Spectrometry In Biopharmaceutical Analysis
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Mass Spectrometry In Biopharmaceutical Analysis
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Author : Igor A. Kaltashov
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-11-22
Mass Spectrometry In Biopharmaceutical Analysis written by Igor A. Kaltashov and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-22 with Science categories.
Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.
Bioanalysis Of Pharmaceuticals
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Author : Steen Honoré Hansen
language : en
Publisher: John Wiley & Sons
Release Date : 2015-07-20
Bioanalysis Of Pharmaceuticals written by Steen Honoré Hansen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-20 with Science categories.
Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Mass Spectrometry In Biopharmaceutical Analysis
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Author : Igor A. Kaltashov
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-11-22
Mass Spectrometry In Biopharmaceutical Analysis written by Igor A. Kaltashov and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-22 with Science categories.
Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.
Bioanalysis Of Pharmaceuticals
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Author : Steen Honor? Hansen
language : en
Publisher: Wiley
Release Date : 2015-06-25
Bioanalysis Of Pharmaceuticals written by Steen Honor? Hansen and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-25 with Science categories.
Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Mass Spectrometry In Medicinal Chemistry
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Author : Klaus Wanner
language : en
Publisher: John Wiley & Sons
Release Date : 2007-06-27
Mass Spectrometry In Medicinal Chemistry written by Klaus Wanner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-27 with Science categories.
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Characterization Of Impurities And Degradants Using Mass Spectrometry
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Author : Guodong Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-27
Characterization Of Impurities And Degradants Using Mass Spectrometry written by Guodong Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-27 with Science categories.
The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products. Both general practitioners in pharmaceutical research and specialists in analytical chemistry field will benefit from this book that will detail step-by-step approaches and new strategies to solve challenging problems related to pharmaceutical research.
Mass Spectrometry For Biotechnology
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Author : Gary Siuzdak
language : en
Publisher: Elsevier
Release Date : 1996-02-12
Mass Spectrometry For Biotechnology written by Gary Siuzdak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-12 with Science categories.
If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics. Glossary of basic terms Abundant illustrations Examples of applications Practical tips on using mass spectrometric techniques Useful for peptide, protein, oligonucleotide, and carbohydrate analysis Simplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI) Electrospray Ionization (ESI) Fast Atom/Ion Bombardment (FAB)
Protein Analysis Using Mass Spectrometry
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Author : Mike S. Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-26
Protein Analysis Using Mass Spectrometry written by Mike S. Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-26 with Science categories.
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Clinical Applications Of Mass Spectrometry In Drug Analysis
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Author : Uttam Garg
language : en
Publisher: Springer Nature
Release Date : 2023-11-30
Clinical Applications Of Mass Spectrometry In Drug Analysis written by Uttam Garg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-30 with Science categories.
This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.
The Expanding Role Of Mass Spectrometry In Biotechnology
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Author : Gary Siuzdak
language : en
Publisher:
Release Date : 2006
The Expanding Role Of Mass Spectrometry In Biotechnology written by Gary Siuzdak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Bioengineering categories.
Covers the basic concepts in mass spectrometry as well as advanced topics including protein identification/protein structural analysis, carbohydrate and oligonucleotide analysis. Topics also include pharmacokinetics, high throughput screening, and the recent development of mass spectrometry in clinical diagnosis.