Characterization Of Impurities And Degradants Using Mass Spectrometry

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Characterization Of Impurities And Degradants Using Mass Spectrometry

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Author : Guodong Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-27

Characterization Of Impurities And Degradants Using Mass Spectrometry written by Guodong Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-27 with Science categories.

The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products. Both general practitioners in pharmaceutical research and specialists in analytical chemistry field will benefit from this book that will detail step-by-step approaches and new strategies to solve challenging problems related to pharmaceutical research.

Modern Forensic Tools And Devices

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Author : Deepak Rawtani
language : en
Publisher: John Wiley & Sons
Release Date : 2023-05-26

Modern Forensic Tools And Devices written by Deepak Rawtani and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-26 with Medical categories.

MODERN FORENSIC TOOLS AND DEVICES The book offers a comprehensive overview of the latest technologies and techniques used in forensic investigations and highlights the potential impact of these advancements on the field. Technology has played a pivotal role in advancing forensic science over the years, particularly in modern-day criminal investigations. In recent years, significant advancements in forensic tools and devices have enabled investigators to gather and analyze evidence more efficiently than ever. Modern Forensic Tools and Devices: Trends in Criminal Investigation is a comprehensive guide to the latest technologies and techniques used in forensic science. This book covers a wide range of topics, from computer forensics and personal digital assistants to emerging analytical techniques for forensic samples. A section of the book provides detailed explanations of each technology and its applications in forensic investigations, along with case studies and real-life examples to illustrate their effectiveness. One critical aspect of this book is its focus on emerging trends in forensic science. The book covers new technologies such as cloud and social media forensics, vehicle forensics, facial recognition and reconstruction, automated fingerprint identification systems, and sensor-based devices for trace evidence, to name a few. Its thoroughly detailed chapters expound upon spectroscopic analytical techniques in forensic science, DNA sequencing, rapid DNA tests, bio-mimetic devices for evidence detection, forensic photography, scanners, microscopes, and recent advancements in forensic tools. The book also provides insights into forensic sampling and sample preparation techniques, which are crucial for ensuring the reliability of forensic evidence. Furthermore, the book explains the importance of proper sampling and the role it plays in the accuracy of forensic analysis. Audience The book is an essential resource for forensic scientists, law enforcement officials, and anyone interested in the advancements in forensic science such as engineers, materials scientists, and device makers.

Handbook Of Isolation And Characterization Of Impurities In Pharmaceuticals

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Author : Satinder Ahuja
language : en
Publisher: Academic Press
Release Date : 2003-07-18

Handbook Of Isolation And Characterization Of Impurities In Pharmaceuticals written by Satinder Ahuja and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-18 with Medical categories.

The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.

Targeted Biomarker Quantitation By Lc Ms

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Author : Naidong Weng
language : en
Publisher: John Wiley & Sons
Release Date : 2017-07-05

Targeted Biomarker Quantitation By Lc Ms written by Naidong Weng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-05 with Medical categories.

The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

Analytical Techniques In The Pharmaceutical Sciences

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Author : Anette Müllertz
language : en
Publisher: Springer
Release Date : 2016-08-30

Analytical Techniques In The Pharmaceutical Sciences written by Anette Müllertz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-30 with Medical categories.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

Mass Spectrometry In Biopharmaceutical Analysis

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Author : Igor A. Kaltashov
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-11-22

Mass Spectrometry In Biopharmaceutical Analysis written by Igor A. Kaltashov and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-22 with Science categories.

Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.

Forensic Chemistry

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Author : Max M. Houck
language : en
Publisher: Academic Press
Release Date : 2015-01-26

Forensic Chemistry written by Max M. Houck and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-26 with Law categories.

Forensic Chemistry is the first publication to provide coordinated expert content from world-renowned leading authorities in forensic chemistry. Covering the range of forensic chemistry, this volume in the Advanced Forensic Science Series provides up-to-date scientific learning on drugs, fire debris, explosives, instrumental methods, interpretation, and more. Technical information, written with the degreed professional in mind, brings established methods together with newer approaches to build a comprehensive knowledge base for the student and practitioner alike. Like each volume in the Advanced Forensic Science Series, review and discussion questions allow the text to be used in classrooms, training programs, and numerous other applications. Sections on fundamentals of forensic science, history, safety, and professional issues provide context and consistency in support of the forensic enterprise. Forensic Chemistry sets a new standard for reference and learning texts in modern forensic science. - Advanced articles written by international forensic chemistry experts - Covers the range of forensic chemistry, including methods and interpretation - Includes entries on history, safety, and professional issues - Useful as a professional reference, advanced textbook, or training review

Protein Analysis Using Mass Spectrometry

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Author : Mike S. Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-19

Protein Analysis Using Mass Spectrometry written by Mike S. Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-19 with Science categories.

Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

Index Medicus

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Author :
language : en
Publisher:
Release Date : 2003

Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medicine categories.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Oral Bioavailability Assessment

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Author : Ayman F. El-Kattan
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-06

Oral Bioavailability Assessment written by Ayman F. El-Kattan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-06 with Medical categories.

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development