Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis
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Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis
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Author : György Berencsi III
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-05
Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis written by György Berencsi III and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-05 with Medical categories.
The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis
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Author :
language : en
Publisher: Springer
Release Date : 2012-04-06
Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-06 with categories.
Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis
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Author : György Berencsi III
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-07
Maternal Fetal Transmission Of Human Viruses And Their Influence On Tumorigenesis written by György Berencsi III and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-07 with Medical categories.
The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
Patho Epigenetics Of Infectious Disease
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Author : Janos Minarovits
language : en
Publisher: Springer
Release Date : 2015-12-11
Patho Epigenetics Of Infectious Disease written by Janos Minarovits and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-11 with Science categories.
Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.
Human Herpesviruses Hhv 6a Hhv 6b And Hhv 7
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Author : Louis Flamand
language : en
Publisher: Elsevier
Release Date : 2014-02-11
Human Herpesviruses Hhv 6a Hhv 6b And Hhv 7 written by Louis Flamand and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-11 with Science categories.
Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases. Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6 Provides expert analysis of T-cell immune response against HHV-6 Presents tools for differential diagnosis in HHV-6 viral infections Includes new information on the previously-largely-unknown biological consequences of ciHHV-6 Offers coverage of new discoveries relating to HHV-7
Rna Dna And Cancer
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Author : Joseph G. Sinkovics
language : en
Publisher: Springer
Release Date : 2016-04-01
Rna Dna And Cancer written by Joseph G. Sinkovics and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-01 with Medical categories.
In this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.
Science Based Bioethics
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Author : John Loike
language : en
Publisher: Lulu.com
Release Date : 2014
Science Based Bioethics written by John Loike and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Bioethics categories.
This book has two primary aims, to analyze how advancing scientific discoveries uncover or elicit bioethical concerns and challenges and to provide the essential scientific background and bioethical information that allows scientists, healthcare professionals and clinical researchers to better comprehend, appreciate and address the complex bioethical dilemmas that our society confronts.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1989
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
Research Grants Index
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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1963
Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1963 with Medicine categories.
Viral Infection At The Maternal Fetal Interface
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Author : Abhay P. S. Rathore
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-28
Viral Infection At The Maternal Fetal Interface written by Abhay P. S. Rathore and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-28 with Medical categories.