Mathematical Modelling Of Chromosome Replication And Replicative Stress
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Mathematical Modelling Of Chromosome Replication And Replicative Stress
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Author : Jens Karschau
language : en
Publisher: Springer
Release Date : 2014-07-11
Mathematical Modelling Of Chromosome Replication And Replicative Stress written by Jens Karschau and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-11 with Science categories.
DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?. A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.
Changing Views On Living Organisms
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Author : Christian Neri
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-04-03
Changing Views On Living Organisms written by Christian Neri and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-03 with Science categories.
Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essentiality and diversity of genomics in contemporary science.
Mathematical Modelling Of The Cell Cycle Stress Response
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Author : Elahe Radmaneshfar
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-08
Mathematical Modelling Of The Cell Cycle Stress Response written by Elahe Radmaneshfar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-08 with Science categories.
The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases. The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.
Energy Research Abstracts
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Author :
language : en
Publisher:
Release Date : 1978-03
Energy Research Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978-03 with Power resources categories.
Yeast Genetics
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Author : Jeffrey S. Smith
language : en
Publisher: Humana
Release Date : 2016-09-17
Yeast Genetics written by Jeffrey S. Smith and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-17 with Science categories.
Yeast Genetics: Methods and Protocols is a collection of methods to best study and manipulate Saccharomyces cerevisiae, a truly genetic powerhouse. The simple nature of a single cell eukaryotic organism, the relative ease of manipulating its genome and the ability to interchangeably exist in both haploid and diploid states have always made it an attractive model organism. Genes can be deleted, mutated, engineered and tagged at will. Saccharomyces cerevisiae has played a major role in the elucidation of multiple conserved cellular processes including MAP kinase signaling, splicing, transcription and many others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Yeast Genetics: Methods and Protocols will provide a balanced blend of classic and more modern genetic methods relevant to a wide range of research areas and should be widely used as a reference in yeast labs.
Genome Duplication
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Author : Melvin DePamphilis
language : en
Publisher: Garland Science
Release Date : 2010-10-06
Genome Duplication written by Melvin DePamphilis and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-06 with Science categories.
Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism. Using examples from the three domains of life - bacteria, archaea, and eukarya - Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division. Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.
New Research Directions In Dna Repair
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Author : Clark Chen
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-05-22
New Research Directions In Dna Repair written by Clark Chen and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.
This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
Plant Cell Division
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Author : Dennis Francis
language : en
Publisher: Ashgate Publishing
Release Date : 1998
Plant Cell Division written by Dennis Francis and has been published by Ashgate Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
This monograph on plant cell division provides a detailed overview of the molecular events which commit cells to mitosis or which affect, or effect mitosis.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1987
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.
Quantitative Fundamentals Of Molecular And Cellular Bioengineering
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Author : K. Dane Wittrup
language : en
Publisher: MIT Press
Release Date : 2020-01-07
Quantitative Fundamentals Of Molecular And Cellular Bioengineering written by K. Dane Wittrup and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Science categories.
A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.