Mechanics Of The Coronary Circulation
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Coronary Circulation
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Author : Ghassan S. Kassab
language : en
Publisher: Springer Nature
Release Date : 2024-08-08
Coronary Circulation written by Ghassan S. Kassab and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-08 with Science categories.
This book covers mechanobiology, growth, remodeling, and clinical implications of coronary artery disease treatment. This volume presents a comprehensive overview of coronary circulation, including growth and remodeling of coronary vasculature, implications to cardiology, and implications to cardiovascular surgery. General principles of biomechanical homeostasis and mechanobiology are outlined. Specifics topics covered include endothelial mechano-transduction, flow reversal, uniform shear, stress & strain hypotheses, scaling laws in coronary artery disease, growth, and aging, and coronary retroperfusion. Coronary Circulation: Mechanobiology, Growth, Remodeling and Clinical Implications is a vital resource for coronary physiologists and cardiovascular disease researchers and bioengineers who want to learn more about mechanobiology and clinical implications to coronary circulation in health and disease.
Pharmacology Of The Coronary Circulation
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Author : Natalii︠a︡ V. Kaverina
language : en
Publisher:
Release Date : 1965
Pharmacology Of The Coronary Circulation written by Natalii︠a︡ V. Kaverina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Cardiovascular agents categories.
"Diseases associated with impairment of the coronary circulation are very common. Hence, the treatment of such diseases is a matter of considerable importance. It is now considered one of the main problems of clinical medicine. The basis for solving the problem is to enlarge our knowledge of the mechanisms of action of the drugs used to treat coronary insufficiency and to find new effective agents. Owing to the complexity of physiological regulation of the coronary circulation, there are many difficulties of a procedural order in studying it experimentally. This was one of the reasons why ideas on the action of many pharmacological agents were derived until recently from the results of experiments involving the isolated heart. When applied to the intact organism, these ideas proved to be inexact and, at times, wrong. Some ideas on the effects of certain drugs were based on experiments involving the intact organism, but the data proved to be inexact due to the inadequacy of the method selected by the authors to determine the mechanism of action of a given substance. Another reason for misconceptions of the effects of some drugs stemmed from insufficient knowledge and contradictory opinions expressed by various investigators on many aspects of the coronary circulation. Now, however, advances in experimental techniques have produced new facts bearing on the physiological regulation of the cardiac blood supply. This has given rise to the need to reexamine some matters concerned with the influence of pharmacological agents on the coronary circulation, relying on modern ideas concerning its physiological regulation and using adequate experimental techniques. Most drugs have complex mechanisms of action owing to the intimate relationship between the processes regulating the cardiac blood supply. Elucidation of these mechanisms requires the use of various techniques, each of which must be suited to the particular aspect under study. This approach will result in a reappraisal of the action of several pharmacological agents on the coronary circulation. Moreover, we believe that the data in this book will be helpful in making more efficient use of these agents in the treatment of various forms of coronary insufficiency."--Introduction.
Coronary Blood Flow
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Author : J.A. Spaan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Coronary Blood Flow written by J.A. Spaan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
by JULIEN IE HOFFMAN One of the earliest coronary physiologists was Scaramucci who, in 1695, postu lated that during systole the contracting myocardium inhibited coronary blood flow. Since then, the many contributions that have been made to our knowledge of the coronary circulation can be arbitrarily divided into three phases based on advances in technical methods. The early phase of research into the coronary circulation, done with great difficulty with crude methods, may be regarded as ending in the 1940s, and it included major discoveries made by such well known investigators as Georg von Anrep, Ernest Starling, Carl Wiggers, and Louis Katz, who formulated much of our basic understanding of the field. After 1940, the field of coronary physiology entered a new phase when instruments for high fidelity registration of coronary flow and pressure became available. This era was domi nated by Donald Gregg who combined careful attention to the function of these instruments (some of which he helped to develop) with an extraordinary ability to discern mechanisms from apparently minor changes in coronary flow and pressure patterns. His book 'The Coronary Circulation in Health and Disease' set a new standard in the field. After 1960, techniques for measuring regional myocardial blood flow became available, and enabled a large group of eminent investigators to make major advances in understanding the physiology and pathophysiology of myocardial blood flow.
Recent Advances In Coronary Circulation
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Author : Yukio Maruyama
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Recent Advances In Coronary Circulation written by Yukio Maruyama and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Coronary circulation research is advancing at a rapid rate. Not only are inno vative techniques for studying myocardial perfusion being developed, new mechanisms related to coronary blood flow control and mechanics are also being discovered. The progress in this field justifies an update in the form of this new monograph. The book is divided into the following sections: "Measurement of Coronary Blood Flow and Assessment of Myocardial Per fusion" discusses advances in perfusion measurements in humans as well as nonradioactive microsphere methods. . "Coronary Flow Dynamics" elucidates the effect of heart contraction on coronary flow, perfusion, and reserve distribution as well as systolic-diastolic interaction. Models-a frequent topic of debate-are used to quantify hypotheses. "Models of Coronary Circulation" attempts to elucidate the concept of tissue pressure. "Regulatory Mechanisms of Coronary circulation and its Clinical Relevance": N u.merous mechanisms affecting coronary flow have been defined and studied at the level of isolated vessels and whole organs. The chapters in this section provide an in-depth analysis of a selection of these mechanisms and their inter actions. "Pathophysiology of Coronary Circulation in Ischemic Heart Disease" considers important aspects of factors which restrict perfusion of the myocardium in ischemic heart disease. An understanding these factors is of crucial importance in the management of patients. "Small Vessel Disorder in Coronary Circulation" describes circulatory flow and how it can be influenced by drugs.
Cardiac Mechanics And Function In The Normal And Diseased Heart
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Author : Masatsugu Hori
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiac Mechanics And Function In The Normal And Diseased Heart written by Masatsugu Hori and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cardiovascular dynamics is a field in which modelling and systems analysis have formed an extremely important discipline. For example, understanding of even such a fundamental function of the circulation as the relationship between central venous pressure apd cardiac output has required evolution of a pertinent model based on years of exhaustive ex perimental investigations by Starling, Starr, and Guyton. Hemodynamic analyses of pulsatile pressures and flows in the arteries and veins have been a continuing challenge taken up by champions of fluid dynamics such as Frank, Wetterer, Taylor, and Wormersley, just to mention a few names, and some kind of model was always proposed as a conceptual framework. An even greater challenge to cardiovascular dynamicists was how to analyze the intermittent coupling of the ventricle and the arterial or venous vasculature through the valve. The availability of numerical solutions by computer and the recently evolved ventricular model with a time-varying elastance and a pressure-dependent internal resistance opened the way to analysis of this coupling. The ever increasing speed of computers has also facilitated trips between the fre quency and the time domain, even on-line for some experimental studies. This book contains many analyses dedicated to the interactions between the heart and the vasculature, providing the reader with findings at the cutting edge of current research in this field.
Analysis And Simulation Of The Cardiac System Ischemia
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Author : Rafael Beyar
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Analysis And Simulation Of The Cardiac System Ischemia written by Rafael Beyar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Computers categories.
Over thiry-five experts contribute to this publication about the various interactions and interrelationships of the parameters which affect the normal and ischemic heart. Mechanical aspects related to the global and regional function of the heart are discussed. Coronary perfusion of the ischemic heart is considered, with emphasis on the effects of reperfusion. Electrical activation, formation of arrhythmias, and the effects of ischemia or ionic transport in the myocardium are presented. Metabolic aspects of the ischemic heart, including calcium transport, are also explained.
Mechanics Of The Coronary Circulation
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Author : Robert E. Mates
language : en
Publisher:
Release Date : 1982
Mechanics Of The Coronary Circulation written by Robert E. Mates and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Biomedical engineering categories.
Computational Cardiovascular Mechanics
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Author : Julius M. Guccione
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-08
Computational Cardiovascular Mechanics written by Julius M. Guccione and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-08 with Technology & Engineering categories.
Computational Cardiovascular Mechanics provides a cohesive guide to creating mathematical models for the mechanics of diseased hearts to simulate the effects of current treatments for heart failure. Clearly organized in a two part structure, this volume discusses various areas of computational modeling of cardiovascular mechanics (finite element modeling of ventricular mechanics, fluid dynamics) in addition to a description an analysis of the current applications used (solid FE modeling, CFD). Edited by experts in the field, researchers involved with biomedical and mechanical engineering will find Computational Cardiovascular Mechanics a valuable reference.
Essential Medical Physiology
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Author : Leonard R. Johnson
language : en
Publisher: Academic Press
Release Date : 2003-09-18
Essential Medical Physiology written by Leonard R. Johnson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-18 with Medical categories.
Textbook covering the principal subjects in a modern medical school physiology course.
Cardiovascular Fluid Mechanics
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Author : Gianni Pedrizzetti
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-10-21
Cardiovascular Fluid Mechanics written by Gianni Pedrizzetti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-21 with Technology & Engineering categories.
The book presents the state of the art in the interdisciplinary field of fluid mechanics applied to cardiovascular modelling. It is neither a monograph nor a collection of research papers, rather an extended review in the field. It is arranged in 4 scientific chapters each presenting thoroughly the approach of a leading research team; two additional chapters prepared by biomedical scientists present the topic by the applied perspective. A unique feature is a substantial (approx. one fourth of the book) medical introductory part, written by clinical researchers for scientific readers, that would require a large effort to be collected otherwise.