Mechanisms And Genetics Of Neurodevelopmental Cognitive Disorders
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Mechanisms And Genetics Of Neurodevelopmental Cognitive Disorders
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Author : Moyra Smith
language : en
Publisher: Academic Press
Release Date : 2021-04-25
Mechanisms And Genetics Of Neurodevelopmental Cognitive Disorders written by Moyra Smith and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-25 with Medical categories.
Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders. - Discusses links between brain development, gene expression, and brain function - Covers neural stem cells, proliferation, migration, differentiation, and neurogenesis - Includes brain mapping, brain plasticity, epigenetics, neuroimmunology, and more - Provides insight into causation and brain function in autism, attention deficit disorder, and learning disabilities - Examines impact of society and environmental factors on mental health
The Genetics Of Neurodevelopmental Disorders
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Author : Kevin J. Mitchell
language : en
Publisher: John Wiley & Sons
Release Date : 2015-08-04
The Genetics Of Neurodevelopmental Disorders written by Kevin J. Mitchell and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-04 with Medical categories.
Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Epigenetic And Genetic Mechanisms Underlying Cardiovascular Diseases And Neurodevelopmental Disorders
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Author : Lingshan Gou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-11
Epigenetic And Genetic Mechanisms Underlying Cardiovascular Diseases And Neurodevelopmental Disorders written by Lingshan Gou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-11 with Medical categories.
Cardiovascular disease (CVD) and neurodevelopmental disorders (NDD) are both common diseases seriously affecting human health. CVD refers to a broad range of disorders including diseases affecting the vasculature, the myocardium, the heart’s electrical circuit, and congenital heart disease. NDDs are conditions affecting brain development and function, mainly characterized by impairments of cognition, communication, and motor skills. Although the heart and brain develop in spatially distinct regions, they share similar genetic factors and molecular pathways which are crucial for a precise developmental trajectory. Actually, congenital CVD survivors are at a higher risk of NDD, and whole-exome sequencing revealed a significant overlap between high-risk congenital CVD and NDD genetic variants. For CVD and NDD, the clinical presentations are heterogeneous, and the etiologies are complex. Elucidating the potential pathogenic mechanisms is good for unveiling the pathophysiology and finding the novel therapeutic target.
Neurocognitive Development Disorders And Disabilities
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-09-25
Neurocognitive Development Disorders And Disabilities written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-25 with Medical categories.
This is one volume of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The disorders and disabilities volume focuses on disorders of intellectual abilities, language, learning memory as well as psychiatric developmental disorders. The developmental aspects of neurological diseases in children is also covered. Chapters discuss when and how these disorders develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. Assessment, treatment, and long-term outcome are provided as well as advances in methods and tools for assessment. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) - Summarizes research on neurocognitive developmental disorders and disabilities - Includes disorders of intellectual abilities, language, learning, memory, and more - Separately covers developmental aspects of neurological diseases in children - Features advances in methods and tools of assessment - Reviews patient care, rehabilitation, and long-term outcomes - Provides interdisciplinary information of use to both researchers and clinicians
Molecular And Genetic Mechanisms In Neurodevelopmental Disorders From Bench To Bedside
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Author : Rebecca Ann Muhle
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-02
Molecular And Genetic Mechanisms In Neurodevelopmental Disorders From Bench To Bedside written by Rebecca Ann Muhle and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Science categories.
Neurocognitive Development Normative Development
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Author :
language : en
Publisher: Elsevier
Release Date : 2019-09-22
Neurocognitive Development Normative Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-22 with Medical categories.
This is one of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The normative volume focuses on neurology, biology, genetics, and psychology of normative cognitive development. It covers the development of intellectual abilities, visual perception, motor function, language, memory, attention, executive function, social cognition, learning abilities, and affect and behavior. The book identifies when and how these functions develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) - Summarizes research on normative neurocognitive development - Includes intellectual abilities, language, memory, attention, motor function, and more - Discusses genetics and environmental influences on development - Provides interdisciplinary information of use to both researchers and clinicians
The Regulatory Genome In Adaptation Evolution Development And Disease
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Author : Moyra Smith
language : en
Publisher: Elsevier
Release Date : 2023-03-10
The Regulatory Genome In Adaptation Evolution Development And Disease written by Moyra Smith and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-10 with Science categories.
The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology. - Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines - Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research - Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence
Brain Protection In Schizophrenia Mood And Cognitive Disorders
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Author : Michael S. Ritsner
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-16
Brain Protection In Schizophrenia Mood And Cognitive Disorders written by Michael S. Ritsner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-16 with Medical categories.
Neuroprotection is a novel perspective for the treatment of disorders that lead to neurodegeneration and disabilities as a result of deterioration of neurons due to apoptosis, oxidative stress, excitotoxicity, and other mechanisms. These mechanisms have implications not only for neurodegenerative disorders, but also for schizophrenia, mood and cognitive disorders. The purpose of this book is to provide an up-to-date overview of basic and clinical studies concerning the neuroprotective approach, mechanisms, and several compounds with neuroprotective properties that may contribute to more efficacious treatment of major mental health disorders. The book is divided into two sections. The first section serves as an introduction and overview of conceptual issues of the neuroprotective approach, and some neurobiological advances. Chapters in this section review definitions, perspectives, and issues that provide a conceptual base for the rest of the book. In addition, this part includes chapters in which the authors present and discuss the findings from basic studies of neurodegenerative mechanisms that are associated with the pathogenesis of major mental health disorders. The second section focuses on findings obtained from clinical trials with neuroprotective compounds, and neuromodulatory techniques. The take-home message is that principles of the neuroprotective approach may be applied to treatment of schizophrenia, mood and cognitive disorders. Contributors to this book are among the most active investigators and clinicians in the field who provide new perspectives not only clarifying ongoing controversies but also propose diverse aspects and new insights to neuroprotection. This book is intended for a broad readership, which includes a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, graduate students, and policy makers in the fields of mental health.
The Oxford Handbook Of Adult Cognitive Disorders
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Author : Robert A. Stern (Ph. D.)
language : en
Publisher:
Release Date : 2019
The Oxford Handbook Of Adult Cognitive Disorders written by Robert A. Stern (Ph. D.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical categories.
The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume that covers most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. The Handbook is appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals.
Neurodevelopmental Mechanisms In Psychopathology
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Author : Dante Cicchetti
language : en
Publisher: Cambridge University Press
Release Date : 2003-08-04
Neurodevelopmental Mechanisms In Psychopathology written by Dante Cicchetti and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-04 with Medical categories.
This volume represents a burgeoning perspective on the origins of psychopathology, one that focuses on the development of the human central nervous system. The contemporary neurodevelopmental perspective assumes that mental disorders result from etiologic factors that alter the normal course of brain development. Defined here in its broadest sense, neurodevelopment is a process that begins at conception and extends throughout the life span. We now know that it is a complex process, and that its course can be altered by a host of factors, ranging from inherited genetic liabilities to psychosocial stressors. This book features the very best thinking in the converging fields of developmental neuroscience and developmental psychopathology. The developmental window represented is broad, extending from the prenatal period through adulthood, and the authors cover a broad range of etiologic factors and a spectrum of clinical disorders. Moreover, the contributors did not hesitate to use the opportunity to hypothesize about underlying mechanisms and to speculate on research directions.