Mechanisms Of Cancer Metastasis
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Mechanisms Of Cancer Metastasis
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Cancer Metastasis written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors.
Mechanisms Of Cancer Metastasis
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Author : Kenneth V Honn
language : en
Publisher:
Release Date : 1985-11-30
Mechanisms Of Cancer Metastasis written by Kenneth V Honn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-11-30 with categories.
Molecular Mechanisms Of Cancer
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Author : Georg F. Weber
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-12
Molecular Mechanisms Of Cancer written by Georg F. Weber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-12 with Medical categories.
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Basic Mechanisms And Clinical Treatment Of Tumor Metastasis
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Author : Motomichi Torisu
language : en
Publisher: Elsevier
Release Date : 2013-09-17
Basic Mechanisms And Clinical Treatment Of Tumor Metastasis written by Motomichi Torisu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-17 with Medical categories.
Basic Mechanisms and Clinical Treatment of Tumor Metastasis provides information pertinent to the basic mechanism of tumor metastasis and the clinical results with immunochemotherapy of cancer. This book explores the extensive studies of clinical trials of cancer immunotherapy by Japanese investigators who played a significant role in the clinical assessment of different immunomodulating drugs. Organized into five parts encompassing 36 chapters, this book begins with an overview of both the in vivo and in vitro behavior of metastatic tumor cells. This text then examines the pathogenesis of cancer metastasis and its possible modulation by immune cells per se of by those treated with immunopotentiators in experimental animals. Other chapters consider the effects of different soluble immune mediators on tumor cell growth and metastasis. This book discusses as well the immunobiology and immunopathology of human tumor cell metastasis. The final chapter deals with successful and unsuccessful trials with cancer immunotherapy using various biological and chemical compounds. This book is a valuable resource for biologists, oncologists, and clinical researchers.
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System
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Author : Haotian Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System written by Haotian Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention
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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
Lung Cancer Metastasis
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Author : Venkateshwar Keshamouni
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
Lung Cancer Metastasis written by Venkateshwar Keshamouni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.
Mechanisms Of Invasion And Metastasis
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Author : Marc M. Mareel
language : en
Publisher: CRC Press
Release Date : 1991-04-23
Mechanisms Of Invasion And Metastasis written by Marc M. Mareel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-04-23 with Medical categories.
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
Cancer Metastasis
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Author : Richard G. Vile
language : en
Publisher: Wiley-Blackwell
Release Date : 1995-04-25
Cancer Metastasis written by Richard G. Vile and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-25 with Medical categories.
A concise description of the metastasis process and its therapeutic relevance in controlling the clinical outcome of the tumor. Explains why the clinical importance of metastasis could be the most life-threatening element in the tumorigenic procedure.
Investigating The Mechanisms Of Cancer Metastasis Through Novel In Vitro And In Vivo Models
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Author : Jerry Xiao
language : en
Publisher:
Release Date : 2022
Investigating The Mechanisms Of Cancer Metastasis Through Novel In Vitro And In Vivo Models written by Jerry Xiao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Biology categories.
Cancer is the second highest cause of death globally. In an estimated 90% of all cases, the spread of cancer cells from the initial tumor to a distant site—aka metastasis—is the primary cause of death. Efforts to develop a metastasis-targeting therapy have been faced with frequent failure in clinical trials despite strong preclinical evidence. This discrepancy is largely the result of inadequate models for capturing the complexities of metastasis. In this thesis work, two novel platforms for evaluating metastatic disease were developed. In one platform, progressively invasive subpopulations of metastatic breast cancer were isolated using xenografted zebrafish embryos and characterized to identify two candidate gene targets whose knockdown can significantly reduce invasive spread. In the other platform, circulating tumor cell (CTC) isolation from whole blood based on cell density produced consistent and robust patient-derived CTC cultures and CTC-derived xenografts (CDXs) in immunocompromised mice. For a subset of these cultures and CDXs, transcriptomic and mutational profiling provided insight into possible metastasis biomarkers. Together, this work provides evidence highlighting potential drivers—both previously known as well as new candidates—of cancer metastasis. In the future, these platforms could be critical to the development of metastasis-targeting therapies as robust models of patient-derived metastasis in personalized medicine.
