Mechanisms Of Cardiac Remodeling And Failure Microform Role Of The Tissue Inhibitor Of Matrix Metalloproteinase 3
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Mechanisms Of Cardiac Remodeling And Failure Microform Role Of The Tissue Inhibitor Of Matrix Metalloproteinase 3
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Author : Paul William Michael Fedak
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004
Mechanisms Of Cardiac Remodeling And Failure Microform Role Of The Tissue Inhibitor Of Matrix Metalloproteinase 3 written by Paul William Michael Fedak and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
TIMPs (tissue inhibitors of metalloproteinases) are complex endogenous biomolecules that contribute to the regulation of tissue architecture and remodeling in both health and disease. Of the four TIMP species, TIMP-3 is unique and its role in the adult heart is undefined. We hypothesized that TIMP-3 plays a key role in initiating, coordinating, and maintaining maladaptive cardiac remodeling in the failing heart. To establish a proof-of-concept that TIMP-3 influences myocardial remodeling and dysfunction, mutant mice lacking TIMP-3 by gene deletion were assessed for altered cardiac structure and function with aging. Cardiomyopathic human and hamster myocardium was similarly assessed for architectural, cellular, and molecular indices of maladaptive remodeling in relation to TIMP-3 expression. The profile of TIMP expression was then assessed in vascular smooth muscle cell-transplanted cardiomyopathic hamster hearts to identify a mechanism through which cell transplantation limits the progression of heart failure. TIMP-3 gene deletion in mice triggered progressive cardiac dilatation and dysfunction consistent with human dilated cardiomyopathy. At the cellular level, loss of TIMP-3 expression resulted in profound cardiac matrix disruption and cell death. At the molecular level, loss of TIMP-3 activated matrix metalloproteinase-9 and the pro-inflammatory TNF-alpha cytokine system. TIMP-3 was reduced in both human and dilated cardiomyopathic hamster myocardium in association with maladaptive cardiac remodeling. In hamster cardiomyopathy, cell transplantation partially restored deficient TIMP-3 and limited maladaptive matrix remodeling. These results suggest that TIMP-3 directly influences matrix homeostasis and cytokine bioactivation in the heart. Altered TIMP-3 expression in the failing heart may directly contribute to maladaptive myocardial tissue remodeling, cardiac dysfunction, and the progression to heart failure. Replacement of deficient TIMP-3 by gene or cell therapy may provide a novel approach to prevent disease progression in patients at risk of heart failure.
Matrix Metalloproteinases And Tissue Remodeling In Health And Disease Cardiovascular Remodeling
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-04-14
Matrix Metalloproteinases And Tissue Remodeling In Health And Disease Cardiovascular Remodeling written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-14 with Science categories.
Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling, Volume 147 contains up-to-date information on the biology and function of matrix metalloproteinases and how their effects on tissue remodeling are altered in diseases of the cardiovascular, pulmonary, and musculoskeletal systems and in other tissues and organs, and in cancer. This latest release covers such highly evolving topics as Biochemical and Biological Attributes of Matrix Metalloproteinases, Matrix Metalloproteinases in Myocardial Infarction and Heart Failure, The Balance Between Metalloproteinases and TIMPs: Critical Regulator of Microvascular Endothelial Cell Function in Health and Disease, and Matrix Metalloproteinases and Platelet Function. As part of the Progress in Molecular Biology and Translational Science, users will find contributions from prominent scientists and highly-recognized experts who have major accomplishments in the research field of matrix metalloproteinases. Focuses on matrix metalloproteinases and their role in tissue remodeling under physiological and pathological conditions Contains up-to-date information on matrix metalloproteinases that is clearly presented in a concise fashion with helpful illustrations and supporting references Includes comprehensive reviews written by prominent scientists and highly-recognized experts in the field of matrix metalloproteinases and tissue remodeling
Cardiac Remodeling
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Author : Barry Greenberg
language : en
Publisher: CRC Press
Release Date : 2005-09-29
Cardiac Remodeling written by Barry Greenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-29 with Medical categories.
Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.
Cardiac Remodeling And Failure
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Author : Pawan K. Singal
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-02-28
Cardiac Remodeling And Failure written by Pawan K. Singal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-28 with Medical categories.
The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.
Myocardial Preservation
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Author : Dennis V. Cokkinos
language : en
Publisher: Springer
Release Date : 2019-01-28
Myocardial Preservation written by Dennis V. Cokkinos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Medical categories.
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.
Fetal Therapy
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Author : Mark D. Kilby
language : en
Publisher: Cambridge University Press
Release Date : 2013
Fetal Therapy written by Mark D. Kilby and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Covers the latest insights any fetal specialist needs and provides essential knowledge for professionals caring for women with high-risk pregnancies.
Extracellular Matrix Degradation
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Author : William C. Parks
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-07
Extracellular Matrix Degradation written by William C. Parks and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-07 with Science categories.
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
The Extracellular Matrix An Overview
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Author : Robert Mecham
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-16
The Extracellular Matrix An Overview written by Robert Mecham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-16 with Science categories.
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Biological Matrices And Tissue Reconstruction
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Author : G. Björn Stark
language : en
Publisher:
Release Date : 1998
Biological Matrices And Tissue Reconstruction written by G. Björn Stark and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
C.A. VACANTI The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. Advances in the medical sciences have enabled physicians to restore lost functions in their patients through or gan transplantation, reconstructive surgery with autogenous tissue transfer, or the implantation of alloplastic materials. Although only recently termed "Tissue Engineering" [1], the use of biological andlor synthetic materials in conjunction with cells to create biologic substitutes to serve as functional tis sue replacements has been explored by modern scientists for several decades. The concept of generating functional tissue from an organ biopsy was de scribed very early in the literature: "The Lord God cast a deep sleep on the man, and while he was asleep, he took out one of his ribs and closed up its place with flesh. The Lord God then built up into a woman the rib that he had taken from the man" [2]. Review of history further reveals that, according to legend, the first homotransplantation of an entire limb was performed by Saints Damian and Cosmas, as depicted by the artist Fra Angelico.
Ct Evaluation Of Coronary Artery Disease
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Author : Paolo Pavone
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-01
Ct Evaluation Of Coronary Artery Disease written by Paolo Pavone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-01 with Medical categories.
Cardiovascular diseases are the leading cause of death in Western countries. In non-fatal cases, they are associated with a decreased quality of life as well as a substantial economic burden to society. Most sudden cardiac events are related to the complications of a non-stenosing marginal plaque. For this reason, the ability to properly identify the atherosclerotic plaque with a rapid, non-invasive technique is of utmost clinical interest in therapeutic planning. Coronary CT angiography produces high-quality images of the coronary arteries, in addition to defining their location and the extent of the atherosclerotic involvement. Proper knowledge of the equipment, adequate preparation of the patient, and accurate evaluation of the images are essential to obtaining a consistent clinical diagnosis in every case. With its clear and concise presentation of CT imaging of the coronary arteries, this volume provides general practitioners and cardiologists with a basic understanding of the technique. For radiologists with no direct experience in cardiac imaging, the book serves as an important source of information on coronary pathophysiology and anatomy.