Home eBooks Download › cardiac remodeling and failure

Cardiac Remodeling And Failure

Download Cardiac Remodeling And Failure PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Cardiac Remodeling And Failure book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Cardiac Remodeling And Failure

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Pawan K. Singal
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Cardiac Remodeling And Failure written by Pawan K. Singal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap tive myocardial as well as humoral responses. When these adaptations or remodel ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

Cardiac Remodeling

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Barry Greenberg
language : en
Publisher: CRC Press
Release Date : 2005-09-29

Cardiac Remodeling written by Barry Greenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-29 with Medical categories.

Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.

Cardiac Remodeling New Insights In Physiological And Pathological Adaptations

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Leonardo Roever
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-15

Cardiac Remodeling New Insights In Physiological And Pathological Adaptations written by Leonardo Roever and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-15 with Electronic book categories.

The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.

Cardiac Remodeling

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Bodh I. Jugdutt
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-15

Cardiac Remodeling written by Bodh I. Jugdutt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-15 with Medical categories.

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

Interstitial Fibrosis In Heart Failure

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Francisco Villarreal
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-17

Interstitial Fibrosis In Heart Failure written by Francisco Villarreal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-17 with Medical categories.

Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.

Surgical Remodeling In Heart Failure

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : W. Brett
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Surgical Remodeling In Heart Failure written by W. Brett and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Despite all efforts and success in medical treatment, the incidence of (end-stage) chronic heart failure is increasing. Cardiac transplantation remains the only definite option; however, due to the shortage of donor organs, very few people benefit. Therefore, surgery of end-stage heart failure using conventional techniques has gained new interest after the introduction of the Batista operation. However, a clear surgical identification of the patients to be included in this group is lacking. Left ventricular reduction surgery as well as reduction of the base of the heart using mitral annuloplasty or mitral valve replacement, sparing both papillary muscles, is used in selected patients with satisfying results and good survival. Long-term mechanical support with subsequent surgical remodeling or supporting myoplasty may result in a beneficial alternative to heart transplantation.

Inflammation In Heart Failure

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Matthijs Blankesteijn
language : en
Publisher: Academic Press
Release Date : 2014-12-05

Inflammation In Heart Failure written by Matthijs Blankesteijn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-05 with Medical categories.

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Mechanisms Of Cardiac Remodeling And Failure Microform Role Of The Tissue Inhibitor Of Matrix Metalloproteinase 3

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Paul William Michael Fedak
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004

Mechanisms Of Cardiac Remodeling And Failure Microform Role Of The Tissue Inhibitor Of Matrix Metalloproteinase 3 written by Paul William Michael Fedak and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

TIMPs (tissue inhibitors of metalloproteinases) are complex endogenous biomolecules that contribute to the regulation of tissue architecture and remodeling in both health and disease. Of the four TIMP species, TIMP-3 is unique and its role in the adult heart is undefined. We hypothesized that TIMP-3 plays a key role in initiating, coordinating, and maintaining maladaptive cardiac remodeling in the failing heart. To establish a proof-of-concept that TIMP-3 influences myocardial remodeling and dysfunction, mutant mice lacking TIMP-3 by gene deletion were assessed for altered cardiac structure and function with aging. Cardiomyopathic human and hamster myocardium was similarly assessed for architectural, cellular, and molecular indices of maladaptive remodeling in relation to TIMP-3 expression. The profile of TIMP expression was then assessed in vascular smooth muscle cell-transplanted cardiomyopathic hamster hearts to identify a mechanism through which cell transplantation limits the progression of heart failure. TIMP-3 gene deletion in mice triggered progressive cardiac dilatation and dysfunction consistent with human dilated cardiomyopathy. At the cellular level, loss of TIMP-3 expression resulted in profound cardiac matrix disruption and cell death. At the molecular level, loss of TIMP-3 activated matrix metalloproteinase-9 and the pro-inflammatory TNF-alpha cytokine system. TIMP-3 was reduced in both human and dilated cardiomyopathic hamster myocardium in association with maladaptive cardiac remodeling. In hamster cardiomyopathy, cell transplantation partially restored deficient TIMP-3 and limited maladaptive matrix remodeling. These results suggest that TIMP-3 directly influences matrix homeostasis and cytokine bioactivation in the heart. Altered TIMP-3 expression in the failing heart may directly contribute to maladaptive myocardial tissue remodeling, cardiac dysfunction, and the progression to heart failure. Replacement of deficient TIMP-3 by gene or cell therapy may provide a novel approach to prevent disease progression in patients at risk of heart failure.

Interstitial Fibrosis In Heart Failure

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Francisco Villarreal
language : en
Publisher: Springer
Release Date : 2008-11-01

Interstitial Fibrosis In Heart Failure written by Francisco Villarreal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Medical categories.

Myocardial Preservation

DOWNLOAD
AUDIOBOOK
READ ONLINE
Author : Dennis V. Cokkinos
language : en
Publisher: Springer
Release Date : 2019-01-28

Myocardial Preservation written by Dennis V. Cokkinos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Medical categories.

This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

Cardiac Remodeling And Failure

Recent Posts