Mechanisms Of Degeneration And Protection Of The Dopaminergic System
DOWNLOAD
AUDIOBOOK
Download Mechanisms Of Degeneration And Protection Of The Dopaminergic System PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Mechanisms Of Degeneration And Protection Of The Dopaminergic System book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Mechanisms Of Degeneration And Protection Of The Dopaminergic System
DOWNLOAD
AUDIOBOOK
Author : Juan Segura-Aguila
language : en
Publisher: F P Graham Company
Release Date : 2001-01-01
Mechanisms Of Degeneration And Protection Of The Dopaminergic System written by Juan Segura-Aguila and has been published by F P Graham Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Dopamine categories.
Central Nervous System Diseases
DOWNLOAD
AUDIOBOOK
Author : Dwaine F. Emerich
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-11-24
Central Nervous System Diseases written by Dwaine F. Emerich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-24 with Medical categories.
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Development And Engineering Of Dopamine Neurons
DOWNLOAD
AUDIOBOOK
Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16
Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Systems Biology Of Free Radicals And Antioxidants
DOWNLOAD
AUDIOBOOK
Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Axon Degeneration
DOWNLOAD
AUDIOBOOK
Author : Elisabetta Babetto
language : en
Publisher: Humana
Release Date : 2020-06-11
Axon Degeneration written by Elisabetta Babetto and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-11 with Science categories.
This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Neurotoxin Modeling Of Brain Disorders Life Long Outcomes In Behavioral Teratology
DOWNLOAD
AUDIOBOOK
Author : Richard M. Kostrzewa
language : en
Publisher: Springer
Release Date : 2016-07-13
Neurotoxin Modeling Of Brain Disorders Life Long Outcomes In Behavioral Teratology written by Richard M. Kostrzewa and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-13 with Medical categories.
This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.
Neuronal Cell Death
DOWNLOAD
AUDIOBOOK
Author : Laura Lossi
language : en
Publisher: Humana
Release Date : 2016-08-23
Neuronal Cell Death written by Laura Lossi and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
This volume represents a valuable and readily reproducible collection of established and emerging techniques for neuronal cell death research. Conveniently divided into four parts, sections cover a series of techniques for the molecular, structural, functional and genomic characterization of dying neurons, a number of protocols that are of primary interest in neuropathology and in experimental neuropathology, a series of gene engineering techniques to obtain and manipulate neuronal stem cells and progenitors, to prepare HSV-1 vectors for the gene therapy, and to CNS transplantation of bone marrow stem cells, and finally, some very interesting protocols for the study of cell death in non-mammalian models. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neuronal Cell Death: Methods and Protocols seeks to serve a large audience of scientists that are currently active in the field or are willing to enter such an exciting and still expanding area of neurobiology.
Inflammation Associated Depression Evidence Mechanisms And Implications
DOWNLOAD
AUDIOBOOK
Author : Robert Dantzer
language : en
Publisher: Springer
Release Date : 2016-12-28
Inflammation Associated Depression Evidence Mechanisms And Implications written by Robert Dantzer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-28 with Medical categories.
Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
Molecular Mechanisms Of Neurodegenerative Diseases
DOWNLOAD
AUDIOBOOK
Author : Marie-Francoise Chesselet
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-10-19
Molecular Mechanisms Of Neurodegenerative Diseases written by Marie-Francoise Chesselet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-19 with Medical categories.
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Apoptosis And Beyond
DOWNLOAD
AUDIOBOOK
Author : James A. Radosevich
language : en
Publisher: John Wiley & Sons
Release Date : 2018-09-18
Apoptosis And Beyond written by James A. Radosevich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-18 with Science categories.
These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
