Mechanisms Of Gene Regulation
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Mechanisms Of Gene Regulation How Science Works
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Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2020-10-29
Mechanisms Of Gene Regulation How Science Works written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-29 with Medical categories.
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
Mechanisms Of Gene Regulation
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Author : Carsten Carlberg
language : en
Publisher: Springer
Release Date : 2016-06-06
Mechanisms Of Gene Regulation written by Carsten Carlberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-06 with Medical categories.
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Mechanisms Of Gene Regulation
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Author : Carsten Carlberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Mechanisms Of Gene Regulation written by Carsten Carlberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedical sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule which states that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Mechanisms Of Gene Expression
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Author : Robert O J Weinzierl
language : en
Publisher: World Scientific
Release Date : 1999-08-10
Mechanisms Of Gene Expression written by Robert O J Weinzierl and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-10 with Science categories.
A detailed knowledge of the mechanisms underlying the transcriptional control of gene expression is of fundamental importance to many areas of contemporary biomedical research, ranging from understanding basic issues (such as control of embryonic development) to practical applications in industry and medicine. Although elementary concepts of gene expression are described in all general molecular biology textbooks, the depth of coverage is often rather limited and recent discoveries are sometimes not adequately taken into consideration. This book presents much of the current thinking concerning molecular mechanisms of transcriptional control in a form easily accessible to undergraduates with an understanding of basic molecular biology concepts. It contains detailed information about the various pro- and eukaryotic transcriptional machineries that has recently become available through the combined efforts of geneticists, biochemists and structural biologists. The book will thus not only serve as an undergraduate text but also offer something new and interesting to more advanced readers and professional scientists who want to keep up to date with rapid advances in this field. Contents:RNA PolymerasesBasal Factors Recognize Promoters and Assemble the Pre-Initiation Transcription ComplexesGene-Specific Transcription FactorsCoactivators: Interface between Gene-Specific and Basal Transcription FactorsControl of RNA Elongation and TerminationRNAPI and RNAPIII Transcriptional MachineriesChromatinNuclear Matrix, Chromosome Scaffolds and Transcriptional FactoriesGene Expression Dynamics and Global Genome Transcription PatternsAppearing on the Horizon: Medical Applications Focusing on Transcriptional Control Mechanisms Readership: Undergraduate and graduate students in molecular biology, biochemistry and genetics. Keywords:Gene Expression;Genetics;Mechanisms;Basal Transcriptional Machinery
Epigenetic Mechanisms Of Gene Regulation
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Author : Vincenzo E. A. Russo
language : en
Publisher:
Release Date : 1996
Epigenetic Mechanisms Of Gene Regulation written by Vincenzo E. A. Russo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Regulation Of Gene Expression
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Author : Gary H. Perdew
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-17
Regulation Of Gene Expression written by Gary H. Perdew and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-17 with Science categories.
The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.
Mechanisms Of Gene Regulation In Cancer Part A
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Author : D.A. Spandidos
language : en
Publisher:
Release Date : 1992-08
Mechanisms Of Gene Regulation In Cancer Part A written by D.A. Spandidos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08 with Science categories.
Part A of the first volume in the series Current Perspectives on Molecular and Cellular Oncology. Topics covered include the molecular genetic approach towards senscence and immortalization and neoplastic transformation in human cell systems in culture.
Mechanisms In Transcriptional Regulation
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Author : Albert J. Courey
language : en
Publisher: John Wiley & Sons
Release Date : 2009-01-22
Mechanisms In Transcriptional Regulation written by Albert J. Courey and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-22 with Science categories.
Mechanisms in Transcriptional Regulation provides a concisediscussion of the fundamental concepts in transcription and itsregulation. Covers RNA polymerases, transcriptional machinery, mechanismsof transcriptional activation, the histone code hypothesis, theepigenetic control of transcription, and combinatorial control insignaling and development Features over 80 figures available to download online Chapters include comprehensive reading lists, boxeshighlighting theoretical concepts and experimental methods andproblems designed to build and test understanding
Genes And Gene Regulation
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Author : Norman Maclean
language : en
Publisher: Hodder Arnold
Release Date : 1989
Genes And Gene Regulation written by Norman Maclean and has been published by Hodder Arnold this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
Discusses the gene itself without emphasizing its DNA components. Written at a level suitable for use by undergraduate students. Annotation copyrighted by Book News, Inc., Portland, OR
Chromatin And Gene Regulation
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Author : Bryan M. Turner
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Chromatin And Gene Regulation written by Bryan M. Turner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Science categories.
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.