Mechanisms Of Innate Neuroprotection
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Mechanisms Of Innate Neuroprotection
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Author : Giuseppe Pignataro
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-27
Mechanisms Of Innate Neuroprotection written by Giuseppe Pignataro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Medicine (General) categories.
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
Mechanisms Of Innate Neuroprotection
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Author :
language : en
Publisher:
Release Date : 2016
Mechanisms Of Innate Neuroprotection written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
Innate Tolerance In The Cns
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Author : Jeffrey M. Gidday
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-21
Innate Tolerance In The Cns written by Jeffrey M. Gidday and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-21 with Medical categories.
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.
Neuroprotection
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Author : Matilde Otero-Losada
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-11-26
Neuroprotection written by Matilde Otero-Losada and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
Neuroprotection
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Author : Raymond Chuen-Chung Chang
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-08-28
Neuroprotection written by Raymond Chuen-Chung Chang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-28 with Medical categories.
Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.
The Handbook Of Neuroprotection
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Author : Kewal K. Jain
language : en
Publisher: Springer
Release Date : 2019-05-15
The Handbook Of Neuroprotection written by Kewal K. Jain and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with Medical categories.
This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.
Neuroprotective Therapy For Stroke And Ischemic Disease
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Author : Paul A. Lapchak
language : en
Publisher: Springer
Release Date : 2017-01-12
Neuroprotective Therapy For Stroke And Ischemic Disease written by Paul A. Lapchak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-12 with Medical categories.
A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.
Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration
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Author : Nesrine Salah El Dine El Sayed
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-14
Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration written by Nesrine Salah El Dine El Sayed and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-14 with Science categories.
Clinical Evaluation Criteria For Aging And Aging Related Multimorbidity
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Author : Ilia Stambler
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Clinical Evaluation Criteria For Aging And Aging Related Multimorbidity written by Ilia Stambler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
Thymosins
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-07-20
Thymosins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-20 with Science categories.
Thymosins, the latest volume in the Vitamins and Hormones series, first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on thymosins research that spans new data from molecular biology to the clinic. Each volume can focus on a single molecule or a disease that is related to vitamins or hormones, with the topic broadly interprested to include related substances, such as transmitters, cytokines, growth factors, and others reviewed. Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormones Contains expertise from world-renowned contributors Includes coverage of a vast array of subjects Presents In-depth, current information at the molecular to the clinical levels