Mechanisms Of Lymphoid Lineage Commitment From Hematopoietic Stem Cell

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Mechanisms Of Lymphoid Lineage Commitment From Hematopoietic Stem Cell
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Author : Anne Lai
language : en
Publisher: ProQuest
Release Date : 2007
Mechanisms Of Lymphoid Lineage Commitment From Hematopoietic Stem Cell written by Anne Lai and has been published by ProQuest this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Cell culture categories.
Hematopoietic stem cells (HSCs) continuously give rise to all lasses of blood cells, which belong to either the lymphoid or myeloid cell lineages, through multiple steps of lineage restriction. It remains unclear how HSCs commit to either the lymphoid or myeloid lineage during early hematopoietic differentiation. My thesis project focused on characterizing multipotent progenitors (MPPs), which are progenies of HSCs that have lost self-renewing ability but retain multi-lineage differentiation potential, in order to understand the developmental events that occur prior to lymphoid lineage commitment.
Mechanisms Of Lymphomagenesis
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Author : Katrina Kaye Hoyer
language : en
Publisher:
Release Date : 2003
Mechanisms Of Lymphomagenesis written by Katrina Kaye Hoyer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Bone Marrow Lymphoid Infiltrates
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Author : Dimitra Anagnostou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-28
Bone Marrow Lymphoid Infiltrates written by Dimitra Anagnostou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-28 with Medical categories.
This monograph aims to cover in depth all aspects of bone marrow lymphoid infiltrates, in the context of their wide spectrum of benign, borderline and malignant expressions. As the bone marrow is no longer considered a selective diagnostic procedure in the field of haematopathology and haematology,but a routine need to other subspecialists, we intend to provide a comprehensive treatise for beginners and experienced practitioners alike who deal with patients that are investigated or treated for lymphomas and lymphoid leukemias, manifest with laboratory or clinical signs suspicious for haematological diseases or show features mimicking haematological conditions.
Epigenetic Regulation Of Lymphocyte Development
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Author : Cornelis Murre
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13
Epigenetic Regulation Of Lymphocyte Development written by Cornelis Murre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Medical categories.
The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Origin And Evolution Of The Vertebrate Immune System
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Author : L. Du Pasquier
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Origin And Evolution Of The Vertebrate Immune System written by L. Du Pasquier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.
Transcriptional Control Of Lineage Differentiation In Immune Cells
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Author : Wilfried Ellmeier
language : en
Publisher: Springer
Release Date : 2014-09-02
Transcriptional Control Of Lineage Differentiation In Immune Cells written by Wilfried Ellmeier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-02 with Medical categories.
Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
Mechanisms In B Cell Neoplasia 1990
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Author : Michael Potter
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Mechanisms In B Cell Neoplasia 1990 written by Michael Potter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.
The Immune Escape Mechanism And Novel Immunotherapeutic Strategies Of Leukemia
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Author : Shenghui Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-02
The Immune Escape Mechanism And Novel Immunotherapeutic Strategies Of Leukemia written by Shenghui Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-02 with Medical categories.
Lymphocyte Development
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Author : Shiv Pillai
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-08-25
Lymphocyte Development written by Shiv Pillai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-25 with Science categories.
"Lymphocyte Development" presents an extremely up-to-date account of molecular processes involved in the development of lymphocytes. This well written book is based on a graduate course taught by the author. Topics include the selection processes involved in lymphocyte maturation, immune receptor gene rearrangement, signaling pathways involved in cell cycle progression and apoptosis, and the transcriptional regulation of lymphoid ontogeny. The book also covers T cell development and differentiation of helper and cytotoxic T cells as well as the development of Natural Killer lymphocytes. The book finishes with an account of the molecular basis of immunodeficiency syndromes. It will interest researchers in immunology and it will be useful as a supplementary text for a graduate level immunology course.
Hematopoietic Stem Cell Biology Lineage Plasticity
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Author : Kenneth Dorshkind
language : en
Publisher:
Release Date : 2002
Hematopoietic Stem Cell Biology Lineage Plasticity written by Kenneth Dorshkind and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cell lines categories.