Mechanisms Of Secondary Brain Damage
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Mechanisms Of Secondary Brain Damage
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Author : A. Baethmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Mechanisms Of Secondary Brain Damage written by A. Baethmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
Mechanisms Of Secondary Brain Damage From Trauma And Ischemia
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Author : A. Baethmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Secondary Brain Damage From Trauma And Ischemia written by A. Baethmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.
Mechanisms Of Secondary Brain Damage In Cerebral Ischemia And Trauma
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Author : Alexander Baethmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Secondary Brain Damage In Cerebral Ischemia And Trauma written by Alexander Baethmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.
Current Progress In The Understanding Of Secondary Brain Damage From Trauma And Ischemia
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Author : A. Baethmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Current Progress In The Understanding Of Secondary Brain Damage From Trauma And Ischemia written by A. Baethmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation – mother nature’s experiment – or hypothermia which is reported to induce cell swelling. Treatment issues deal also with thrombolysis and combination therapies, or with the clearance of adverse blood components – LDL/fibrinogen – by a novel procedure using heparin. Other highlights are discussing the specificities of pediatric vs. adult brain trauma, or the evolving role of the Apolipoprotein-E e4 gene in severe head injury. An update is also provided on an online assessment of the patient management during the pre- and early hospital phase in Southern Bavaria. The empirical observation of neuroworsening is analyzed in further details, whether this is a specificity autonomously driving the posttraumatic course. Finally, the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis.
Understanding The Mechanism Of Traumatic Brain Injury Induced Energy Metabolism
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Author : Guoqiang Xing
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-24
Understanding The Mechanism Of Traumatic Brain Injury Induced Energy Metabolism written by Guoqiang Xing and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-24 with Medical categories.
Mechanisms Of Secondary Brain Damage
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Author : Springer
language : en
Publisher:
Release Date : 2014-01-15
Mechanisms Of Secondary Brain Damage written by Springer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Brain Injury Medicine
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Author : Nathan D. Zasler
language : en
Publisher: Demos Medical Publishing
Release Date : 2007
Brain Injury Medicine written by Nathan D. Zasler and has been published by Demos Medical Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Covers the full continuum from early diagnosis and evaluation through rehabilitation, post-acute care, and community re-entry. Includes assessment and treatment, epidemiology, pathophysiology, neuroanatomy, neuroimaging, the neuroscientific basis for rehabilitation, ethical and medicolegal issues, life-care planning, and more.
Case Based Review In Critical Care Medicine
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Author : Atul Prabhakar Kulkarni
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2019-06-30
Case Based Review In Critical Care Medicine written by Atul Prabhakar Kulkarni and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-30 with Medical categories.
This book is a comprehensive guide to critical care medicine for postgraduate medical students. Presented in a case-based, question and answer format, the text begins with guidance on patient examination in the intensive care unit (ICU). Each of the following chapters covers a different disorder, from acute severe asthma, pulmonary embolism and septic shock, to traumatic brain injury, acute liver failure and much more. The book concludes with cases examining out-of-hospital cardiac arrest, brain death and organ donation, as well as end-of-life care in the ICU. A large selection of Objective Structured Clinical Examination (OSCE) practice questions are included to assist students in their preparation for examinations. Nearly 300 clinical photographs, illustrations and tables further enhance learning. Key points Comprehensive guide to critical care medicine for postgraduates Presented in a case-based, question and answer format Includes numerous OSCE practice questions to help students prepare for examinations Highly illustrated with clinical photographs, diagrams and tables
Roger S Textbook Of Pediatric Intensive Care
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Author : Donald H. Shaffner
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2023-08-14
Roger S Textbook Of Pediatric Intensive Care written by Donald H. Shaffner and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-14 with Medical categories.
Long recognized as the leading text in this dynamic field, Rogers’ Textbook of Pediatric Intensive Care provides comprehensive, clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied. Led by Drs. Donald H. Shaffner, John J. McCloskey, Elizabeth A. Hunt, and Robert C. Tasker, along with a team of 27 section editors as well as more than 250 expert global contributors, the fully revised Sixth Edition brings you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.
Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies
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Author : Shuxin Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies written by Shuxin Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.