Mediators And Drugs In Gastrointestinal Motility I
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Mediators And Drugs In Gastrointestinal Motility I
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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mediators And Drugs In Gastrointestinal Motility I written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the exhaustive Handbook of Physiology (Alimentary Canal, Section 6, Motility) edited by CHARLES F. CODE in 1968, no complete survey of the morphological basis and the physiological control of intestinal motility has been published, in spite of the enormous amount of new data in the literature on this topic. The new techniques and methodologies, the use of electron microscopy, radioimmunoassay and binding techniques, as weIl as ever more sophisticated electrophysiological procedures have made possible areal flood of discoveries in this field. Moreover, the possibility ofnew studies ofthe endocrine cells in biopsies of human intestinal mucosa even during routine endoscopies, has opened new horizons for gastroenterologists and generated a number of important contribu tions to our knowledge of the morphology and physiopathology of the gut. As usual, new discoveries have also revealed both ignorance and many new problems. For tbis reason, although many of the data reported in this volume can be considered as firmly established, others still require confirmation, and the results of new research in this field are awaited with extreme interest. Since advances are occurring so rapidly, even experts in the specific topics need frequent comprehensive reviews. To avoid an excessively large volume, considera tions ofthe pancreas, liver, and biliary system were not included in this Handbook, which, nevertheless, has attempted to off er the reader the essence of more than 1,500 papers.
Mediators And Drugs In Gastrointestinal Motility Ii
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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mediators And Drugs In Gastrointestinal Motility Ii written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume places more emphasis on endogenous mediators of gut motility than on drugs used to treat patients with deranged motility. In this respect it resembles most other books on gastroenterology, for while only a relatively small number of drugs are really useful for a rational therapy, a tremendous amount of data is available on neural and hormonal factors regulating the motility of the alimentary canal. Moreover, it must be considered that some of the drugs which can routinely be employed to modify deranged motility of the digestive system are represented by pure or slightly modified endogenous compounds (e. g. , cholecystokinin, its C terminal octapeptide and caerulein), and it is easy to foresee that their number is destined to increase in the near future. Other drugs are simply antagonists of physiological substances acting on specific receptors (e. g. , histamine H -blockers 2 and opioid compounds). The real explosion of research in this field and the extreme specialization often connected with the use of very sophisticated techniques and methodologies would probably have required a larger number of experts to cover some very specific fields from both an anatomical (lower esophageal sphincter, stomach, pylorus, small and large intestine) and a biochemical (hormones, candidate hormones, locally active substances, neurotransmitters etc. ) point of view.
Mediators And Drugs In Gastrointestinal Motility I
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Author : H. G. Baumgarten
language : en
Publisher:
Release Date : 1982-06
Mediators And Drugs In Gastrointestinal Motility I written by H. G. Baumgarten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-06 with categories.
Mediators And Drugs In Gastrointestinal Motility
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Author : Giulio Bertaccini
language : en
Publisher:
Release Date : 1982
Mediators And Drugs In Gastrointestinal Motility written by Giulio Bertaccini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Gastrointestinal agents categories.
Mediators And Drugs In Gastrointestinal Motility I
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Author :
language : en
Publisher: Springer
Release Date : 1982-06-01
Mediators And Drugs In Gastrointestinal Motility I written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-06-01 with Medical categories.
Since the exhaustive Handbook of Physiology (Alimentary Canal, Section 6, Motility) edited by CHARLES F. CODE in 1968, no complete survey of the morphological basis and the physiological control of intestinal motility has been published, in spite of the enormous amount of new data in the literature on this topic. The new techniques and methodologies, the use of electron microscopy, radioimmunoassay and binding techniques, as weIl as ever more sophisticated electrophysiological procedures have made possible areal flood of discoveries in this field. Moreover, the possibility ofnew studies ofthe endocrine cells in biopsies of human intestinal mucosa even during routine endoscopies, has opened new horizons for gastroenterologists and generated a number of important contribu tions to our knowledge of the morphology and physiopathology of the gut. As usual, new discoveries have also revealed both ignorance and many new problems. For tbis reason, although many of the data reported in this volume can be considered as firmly established, others still require confirmation, and the results of new research in this field are awaited with extreme interest. Since advances are occurring so rapidly, even experts in the specific topics need frequent comprehensive reviews. To avoid an excessively large volume, considera tions ofthe pancreas, liver, and biliary system were not included in this Handbook, which, nevertheless, has attempted to off er the reader the essence of more than 1,500 papers.
Mediators And Drugs In Gastrointestinal Motility Morphological Basis And Neurophysiological Control
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Author : H. G. Baumgarten
language : en
Publisher: Springer
Release Date : 1982
Mediators And Drugs In Gastrointestinal Motility Morphological Basis And Neurophysiological Control written by H. G. Baumgarten and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medical categories.
Mediators And Drugs In Gastrointestinal Motility Ii
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Author : A. Bennett
language : en
Publisher:
Release Date : 1982-07-01
Mediators And Drugs In Gastrointestinal Motility Ii written by A. Bennett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-07-01 with categories.
Colonic Motility
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Author : Sushil K. Sarna
language : en
Publisher: Biota Publishing
Release Date : 2010-11-01
Colonic Motility written by Sushil K. Sarna and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-01 with Medical categories.
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Mechanisms Of Gastrointestinal Motility And Secretion
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Author : A. Bennett
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Mechanisms Of Gastrointestinal Motility And Secretion written by A. Bennett and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.
Gastrointestinal Motility
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Author : D. Grundy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gastrointestinal Motility written by D. Grundy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The basis of this book is a ten-lecture course on the control of gastrointesti nal motility given each year to the final year undergraduate students in Physiology at Sheffield University. A naive thought led me to believe that the conversion of my lecture notes into the present book would be a relatively easy task. I now know differently. As there is no equivalent undergraduate course elsewhere that I know of, it would be dishonest of me to claim this book to be an undergraduate text. The comprehensive way in which I have dealt with the subject, together with the inclusion of the most up-to-date material, make the book more relevant to postgraduate students of physiology, medicine and related sciences who require an introduction to the field of gastrointestinal motility and its control. I have, however, attempted to present the current concepts on the physiological mechanisms regulating motility in a way which under graduates, as well as postgraduates, will find readable, informative and, hopefully, enjoyable.