Mediators In The Cardiovascular System
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Mediators In The Cardiovascular System
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Author : Karsten Schrör
language : en
Publisher: Copernicus
Release Date : 1995
Mediators In The Cardiovascular System written by Karsten Schrör and has been published by Copernicus this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Intracellular Signaling Mediators In The Circulatory And Ventilatory Systems
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Author : Marc Thiriet
language : en
Publisher: Springer
Release Date : 2012-09-26
Intracellular Signaling Mediators In The Circulatory And Ventilatory Systems written by Marc Thiriet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-26 with Science categories.
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
The Role Of Inflammatory Mediators In The Failing Heart
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Author : Douglas L. Mann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Role Of Inflammatory Mediators In The Failing Heart written by Douglas L. Mann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states. Over the past decade there has been increasing interest in the potential role that inflammatory mediators, play in a variety of cardiac disease states, including chronic heart failure. The Role of Inflammatory Mediators in the Failing Heart provides a state-of-the-art review on inflammatory mediators and the failing heart. This book will serve both as a useful introduction to the field, as well as an update for those interested in the role of inflammatory mediators and the failing heart.
Vascular Neuroeffector Mechanisms
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Author : John A. Bevan
language : en
Publisher: IRL Press
Release Date : 1988
Vascular Neuroeffector Mechanisms written by John A. Bevan and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
This book is essential reading for all basic or clinical researchers who are interested in the neuronal control of vascular function. It continues the authoritative series of symposia on vascular neuroeffector mechanisms which are held every three years as an official satellite of the International Congress of Pharmacology. This latest volume, the sixth in the series, derives from a meeting held in Australia, August 30-September 2, 1987. The contributions collected here describe and disseminate some of the most recent discoveries on vascular neuroeffector transmission. Written by leading scientists in the field, they reflect substantial increases in our knowledge of neurohumoral transmission processes in general, and about vascular neuroeffector transmission in particular.
Tissue Functioning And Remodeling In The Circulatory And Ventilatory Systems
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Author : Marc Thiriet
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-01-11
Tissue Functioning And Remodeling In The Circulatory And Ventilatory Systems written by Marc Thiriet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-11 with Science categories.
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
The Nervous System And The Heart
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Author : Gert J. Ter Horst
language : en
Publisher: Springer Science & Business Media
Release Date : 2000
The Nervous System And The Heart written by Gert J. Ter Horst and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
There are physiological bases for associations of the heart with emotions, and with the apparently universal increased mortality in winter. Thirteen contributions integrate expertise in cardiology and neuroscience in overviewing the latest knowledge about head-heart interactions. The first five chapters explain autonomic control of cardiovascular functions, the neural supply of the heart, and neuropathology. Part II examines the effects of stress on the hypothalamo-pituitary-adrenal system and the heart. Part III treats the neurobiology and neuroimaging of cardiac pain. Next, humoral factors in cardiovascular regulation and as mediators of inflammation in coronary artery disease are considered. Finally, the relationship between heart disease and cognitive/neuropsychiatric disorders is discussed. Includes photomicrographs, schematic drawings, and nice large print.
Inflammation In Heart Failure
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Author : Matthijs Blankesteijn
language : en
Publisher: Academic Press
Release Date : 2014-12-05
Inflammation In Heart Failure written by Matthijs Blankesteijn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-05 with Medical categories.
Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases
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Author : Kenneth V. Honn
language : en
Publisher: Springer Nature
Release Date : 2019-09-27
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases written by Kenneth V. Honn and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-27 with Medical categories.
The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.
The Endothelium
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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Social Isolation And Loneliness In Older Adults
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-05-14
Social Isolation And Loneliness In Older Adults written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-14 with Social Science categories.
Social isolation and loneliness are serious yet underappreciated public health risks that affect a significant portion of the older adult population. Approximately one-quarter of community-dwelling Americans aged 65 and older are considered to be socially isolated, and a significant proportion of adults in the United States report feeling lonely. People who are 50 years of age or older are more likely to experience many of the risk factors that can cause or exacerbate social isolation or loneliness, such as living alone, the loss of family or friends, chronic illness, and sensory impairments. Over a life course, social isolation and loneliness may be episodic or chronic, depending upon an individual's circumstances and perceptions. A substantial body of evidence demonstrates that social isolation presents a major risk for premature mortality, comparable to other risk factors such as high blood pressure, smoking, or obesity. As older adults are particularly high-volume and high-frequency users of the health care system, there is an opportunity for health care professionals to identify, prevent, and mitigate the adverse health impacts of social isolation and loneliness in older adults. Social Isolation and Loneliness in Older Adults summarizes the evidence base and explores how social isolation and loneliness affect health and quality of life in adults aged 50 and older, particularly among low income, underserved, and vulnerable populations. This report makes recommendations specifically for clinical settings of health care to identify those who suffer the resultant negative health impacts of social isolation and loneliness and target interventions to improve their social conditions. Social Isolation and Loneliness in Older Adults considers clinical tools and methodologies, better education and training for the health care workforce, and dissemination and implementation that will be important for translating research into practice, especially as the evidence base for effective interventions continues to flourish.