Membrane Trafficking
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Membrane Trafficking
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Author : Ales Vancura
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-28
Membrane Trafficking written by Ales Vancura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-28 with Science categories.
As membrane trafficking research has expanded over the past thirty years, a remarkable convergence of information has been gained by using genetic approaches in yeast cells with biochemical approaches in mammalian cells. This book reflects these advances by devoting one section of the book to yeast cells and the other to mammalian cells, with each section providing both classic and cutting-edge techniques to study macromolecular transport across the membranes.
Membrane Trafficking
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Author : Jingshi Shen
language : en
Publisher: Springer Nature
Release Date : 2022-07-12
Membrane Trafficking written by Jingshi Shen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with Science categories.
This detailed volume presents a series of methods exploring membrane trafficking research, ranging from genetics and high-resolution imaging to in vitro biochemical and biophysical assays. Covering virtually all the major trafficking branches, the book delves into the exocytic pathway, which focuses on cargo transport from the ER to the Golgi, through the Golgi cisternae, and to the plasma membrane and the extracellular space; the endocytic pathway, which includes cargo endocytosis, endosomal recycling, and lysosomal degradation; as well as emerging topics beyond the conventional exocytic and endocytic pathways. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Membrane Trafficking: Methods and Protocols provides techniques with broad applications as an ideal guide for junior researchers new to membrane trafficking as well as established membrane biologists seeking to expand their research programs.
Connections To Membrane Trafficking Where You Least Expect Them Diseases Dynamics Diet And Distance
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Author : Rachel Susan Kraut
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-28
Connections To Membrane Trafficking Where You Least Expect Them Diseases Dynamics Diet And Distance written by Rachel Susan Kraut and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-28 with categories.
Membrane Trafficking
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Author : Bor Luen Tang
language : en
Publisher:
Release Date : 2015
Membrane Trafficking written by Bor Luen Tang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Biological transport categories.
Annotation This second edition explores membrane trafficking research that has been at the frontier of cell and molecular biology. In the past 20 years, this field has witnessed a remarkable convergence and synergism from information gained using genetic approaches in yeast cells, and biochemical and molecular approaches in mammalian cells. This volume contains updated chapters and the inclusion of a large number of new chapters, and is divided into three parts. Part I includes biochemical and molecular genetics approaches and methods used in analysing membrane traffic, in both yeast and mammalian cell models. Part II focuses on imaging and microscopy approaches and techniques, while Part III highlights the Omics-type approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and resourceful, Membrane Trafficking, Second Edition, is a valuable resource for both experienced researchers, graduate students, and junior scientists in the field of membrane trafficking.
Membrane Trafficking In Viral Replication
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Author : Mark Marsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25
Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.
Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.
Crosstalk And Integration Of Membrane Trafficking Pathways
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Author : Roberto Weigert
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-04-11
Crosstalk And Integration Of Membrane Trafficking Pathways written by Roberto Weigert and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-11 with Science categories.
Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk.
Overview Of Membrane Trafficking Pathways
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Author : Jill Lynch
language : en
Publisher:
Release Date : 2015-03-31
Overview Of Membrane Trafficking Pathways written by Jill Lynch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-31 with categories.
An overview of membrane trafficking pathways has been provided in this all-inclusive book. Membrane traffic is a wide domain that deals with complex exchange of membranes that occurs inside a cell. Protein, lipids and other molecules travel among intracellular organelles, are delivered to or transferred from the cell surface by virtue of membranous carriers known as "transport intermediates." These carriers have distinct shapes and sizes; and their biogenesis, mode of transport and delivery to the final destination are monitored by a multitude of very intricate molecular mechanisms. The concept that every membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways has emerged in past few years. This book intends to present a general overview of the degree of this crosstalk.
Energy Requirements In Membrane Trafficking
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Author : Carlos M. Guardia
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-07
Energy Requirements In Membrane Trafficking written by Carlos M. Guardia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-07 with Science categories.
Localization And Movement
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Author : Peter Leader Lee
language : en
Publisher:
Release Date : 2011
Localization And Movement written by Peter Leader Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Membrane trafficking is an essential process that enables cells to deliver proteins to the extracellular space and segregate proteins into different compartments. Several steps are necessary for the functional segregation and processing of proteins. Trafficking includes post-translational modification of proteins, their movement between compartments, and stable localization once they have reached their target destinations. Importantly, membrane trafficking represents a recursively-sustained system: proteins that play a role in the regulation of membrane trafficking must also be properly transported and localized. Chapter one introduces the importance of the Golgi in the sorting and packaging of proteins and the roles of molecular motors in facilitating individual transport events. To modify transported cargoes, Golgi resident glycosyltransferases need to be localized to the correct cisternae and in some cases, in correct complex with other glycosyltransferases. "Kin recognition", the association of enzymatically compatible glycosyltransferases, has been demonstrated as a mechanism for the stable localization of glycosyltransferases to their proper compartments. Myosins, dyneins, and kinesins, linked to membranes by small Rab GTPases and their effectors, play important roles in moving cargo on actin and microtubule filaments. Their regulation by adapter proteins and their combinatorial interactions both complementing and opposing movement allows for the fine tuning of cargo transport. Chapter two presents the association of UDP-GlcNAc:[beta]Gal [beta]-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) and UDP-Gal:[beta]GlcNAc [beta]-1,4-galactosyltransferase, polypeptide 1 (B4GALT1). These two glycosyltransferases participate in the alternating, successive polymerization of poly-N-acetyllactosamine (polyLacNAc), a linear carbohydrate polymer composed of alternating N-acetylglucosamine and galactose residues. We show that these two glycosyltransferases colocalize by immunofluorescence microscopy, interact by coimmunoprecipitation, and when artificially retained in the ER can retain the complementary glycosyltransferase there as well. Chapter three presents the novel regulation of the KIF3 family kinesin, KIF1C, by small Rab GTPases, Rab1 and Rab6. The depletion of KIF1C impairs the plasma membrane delivery of Vesicular stomatitis virus G protein and intriguingly increases the speed of both Rab1 and Rab6 labeled vesicles. Rab6 can bind directly to the C-terminal domain of KIF1C and, like Rab1, can additionally interact with KIF1C's N-terminal motor domain. The interaction of KIF1C with Rab6 diminishes KIF1C's ability to bind microtubules. These results suggest that KIF1C acts as a brake, perhaps slowing transport to allow proper packaging and tethering to occur. Our data suggest that interaction between Rab6 and KIF1C could relieve KIF1C's braking action by displacing it from microtubules; alternatively, KIF1C may function as a molecular tether between membranes carrying Rab1 and/or Rab6.
Membrane Trafficking In Viral Replication
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Author : Mark Marsh
language : en
Publisher:
Release Date : 2005
Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Biological transport categories.
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.