Overview Of Membrane Trafficking Pathways
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Overview Of Membrane Trafficking Pathways
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Author : Jill Lynch
language : en
Publisher:
Release Date : 2015-03-31
Overview Of Membrane Trafficking Pathways written by Jill Lynch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-31 with categories.
An overview of membrane trafficking pathways has been provided in this all-inclusive book. Membrane traffic is a wide domain that deals with complex exchange of membranes that occurs inside a cell. Protein, lipids and other molecules travel among intracellular organelles, are delivered to or transferred from the cell surface by virtue of membranous carriers known as "transport intermediates." These carriers have distinct shapes and sizes; and their biogenesis, mode of transport and delivery to the final destination are monitored by a multitude of very intricate molecular mechanisms. The concept that every membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways has emerged in past few years. This book intends to present a general overview of the degree of this crosstalk.
Trafficking Inside Cells
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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30
Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Crosstalk And Integration Of Membrane Trafficking Pathways
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Author : Roberto Weigert
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-04-11
Crosstalk And Integration Of Membrane Trafficking Pathways written by Roberto Weigert and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-11 with Science categories.
Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk.
Crosstalk And Integration Of Membrane Trafficking Pathways
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Author : Roberto Weigert
language : en
Publisher:
Release Date : 2012
Crosstalk And Integration Of Membrane Trafficking Pathways written by Roberto Weigert and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk.
Protein Lipid And Membrane Traffic
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Author : North Atlantic Treaty Organization. Scientific Affairs Division
language : en
Publisher: IOS Press
Release Date : 2000
Protein Lipid And Membrane Traffic written by North Atlantic Treaty Organization. Scientific Affairs Division and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Biological transport categories.
This text concentrates on the following specific topics: the dynamic character of lipids and proteins in biological membranes; the existence of specific domains in membranes including their visualisation; the molecular mechanisms of intracellular transport of membrane constituents and the involvement of lipid-protein interactions in these processes; protein assembly; structure and folding and transport through membranes; and the intracellular sorting and targeting of individual membrane components as well as different organelles."
Membrane Trafficking
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Author : Jingshi Shen
language : en
Publisher: Springer Nature
Release Date : 2022-07-12
Membrane Trafficking written by Jingshi Shen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with Science categories.
This detailed volume presents a series of methods exploring membrane trafficking research, ranging from genetics and high-resolution imaging to in vitro biochemical and biophysical assays. Covering virtually all the major trafficking branches, the book delves into the exocytic pathway, which focuses on cargo transport from the ER to the Golgi, through the Golgi cisternae, and to the plasma membrane and the extracellular space; the endocytic pathway, which includes cargo endocytosis, endosomal recycling, and lysosomal degradation; as well as emerging topics beyond the conventional exocytic and endocytic pathways. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Membrane Trafficking: Methods and Protocols provides techniques with broad applications as an ideal guide for junior researchers new to membrane trafficking as well as established membrane biologists seeking to expand their research programs.
Biosynthetic Membrane Trafficking Pathways In Neurons
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Author : Michelle Anne Burack
language : en
Publisher:
Release Date : 2003
Biosynthetic Membrane Trafficking Pathways In Neurons written by Michelle Anne Burack and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Membrane Trafficking And Endocytosis In Neurons
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Author : Ayesha Murshid
language : en
Publisher:
Release Date : 2008
Membrane Trafficking And Endocytosis In Neurons written by Ayesha Murshid and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
"In mammalian cells, two main membrane trafficking pathways, the secretory and endocytic pathways are important for many biological functions. Secretory proteins are synthesized on ribosomes inside the cells, translocated into the ER for proper folding, later mature in the Golgi and continue their journey to the plasma membrane. Endocytosis is defined as a process of vesicle formation from the plasma membrane, where external solutes like nutrients, growth factors and transmembrane proteins are internalized by the cell to endosomal compartments. Internalized protein can either be degraded in lysosomes or recycled back to the plasma membrane. Clathrin mediated endocytosis (CME) is one of the most commonly used endocytic mechanisms in mammalian cells and its mechanism has been intensively studied over the years. Clathrin with the help of other adaptor/accessory proteins are able to form vesicles in the plasma membrane which are removed from the membrane by dynamin. There are many other kinds of internalization pathways which include phagocytosis, macropinocytosis, caveolae-dependent endocytosis, and caveolae and clathrin-independent endocytosis. In the first part of the thesis, we characterized a newly identified WVQF motif containing, AP2-binding protein, NECAP1 in neurons. We found that NECAP1 plays a vital role in the CME of transferrin and synaptotagmin in neuronal cells. In the second part, we studied endocytosis of nerve growth factor (NGF) receptor (TrkA) in PC 12 cells. At a low dose (1 ng/ml) of NGF, we found that CME of TrkA is AP2- and NECAP1-independent in PC12 cells and that beta arrestin 1 can act as an alternate adaptor for its internalization. At higher extracellular concentration of NGF, uptake is clathrin- and dynamin- and beta-arrestin 1-independent, but requires actin, Cdc42 and sphingolipids, suggesting a different pathway. Our results show that large extracellular concentrations of NGF lead to strong signals of finite duration which is later terminated by degradation of NGF or NGF-TrkA whereas low concentrations of NGF leads to long lived signals. In the third chapter, we characterized newly identified Rabs, mainly Rab18 and Rab43. We found that Rab18 is involved in COPI independent trafficking of cargo beta-1,4-galactosyltransferase (Galtase)-YFP suggesting its role in retrograde trafficking from Golgi to ER, whereas Rab43 has a regulatory role in the interaction between microtubule and pre-Golgi intermediates possibly via interaction with motor proteins. Taken together, the data in this thesis contribute to our understanding of the endocytic and secretory pathways of mammalian cells."--
Membrane Trafficking In Viral Replication
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Author : Mark Marsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25
Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.
Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.