Membrane Transport Mechanism
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Membrane Transport Mechanism
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Author : Reinhard Krämer
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-03-13
Membrane Transport Mechanism written by Reinhard Krämer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-13 with Science categories.
This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Receptors Membrane Transport And Signal Transduction
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Author : A.E. Evangelopoulos
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Receptors Membrane Transport And Signal Transduction written by A.E. Evangelopoulos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
A NATO Advanced study Institute on "Receptors, Membrane Trans port and Signal Transduction", was held on the Island of Spet sai, Greece, from August 16-27, 1988, in order to consider re cent developments in membrane receptor research, membrane trans port and signal transduction mechanisms. These topics were put in the larger context of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth dis cussions of energy transduction and transport mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation were presented in the context of specific cellular processes. Discussions included al so the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in va rious aspects of cell development and transformation. This book presents the content of the major lectures and a se lection of the most relevant posters presented during the course of the Institute. The book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics on receptors, membrane transport and signal transduction that were discussed extensive ly during the course of the Institute. February 1989 The Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN PHOSPHORYLATION Selective regulation of G proteins by Cell surface receptors ......... .
Transport Mechanisms In Membrane Separation Processes
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Author : J.G.A. Bitter
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Transport Mechanisms In Membrane Separation Processes written by J.G.A. Bitter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present book contains a comparison of existing theoretical models developed in order to describe membrane separation processes. In general, the permeation equations resulting from these models give inaccurate predictions of the mutual effects of the permeants involved, due to the simplifications adopted in their derivation. It is concluded that an optimum description of transport phenomena in tight (diffusion-type) membranes is achieved with the "solution-diffusion" model. According to this model each component of a fluid mixture to be separated dissolves in the membrane and passes through by diffusion in response to its gradient in the chemical potential. A modified Flory-Huggins equation has been derived to calculate the solubility of the permeants in the membrane material. Contrary to the original Flory-Huggins equation, the modified equation accounts for the large effect on solubility of crystallinity and elastic strain of the polymer chains by swelling. The equilibrium sorption of liquids computed with this equation was found to be in good agreement with experimental results. Also, the sorption of gases in both rubbery and glassy polymers could be described quan titatively with the modified Flory-Huggins equation without any need of the arbitrary Langmuir term, as required in the conventional "dual-mode" sorption model. Furthermore, fewer parameters are required than with the at least identical accuracy.
Cell Membrane Transport
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Author : Arnost Kotyk
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Membrane Transport written by Arnost Kotyk and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
TO THE SECOND EDITION When preparing the manuscript for the original edition of this book we were only partly aware of the pace at which the field of membrane transport was developing and at which new ideas as well as new techniques would be applied to it. The fact is that some of the chapters are now outdated (e. g. , the one on the molecular aspects of transport) and many others require revision in the light of new information that has appeared in the past five years. However, it is also true that we overemphasized in the first edition certain points that now appear less important and underestimated the impact of certain others that have since assumed a position among the most forcefully discussed topics of membrane research. In making amends, it was thus thought useful to include the discussion of these latter problems both in the theoretical and in the comparative sections and, on the other hand, to omit some of the less topical subjects. There was a different reason for rewriting the section on kidney and for dropping the section on mito chondria. The help of an expert nephrologist was enlisted for improving chapter 24, while it was decided that mitochondria represent a special field both conceptually (being only subcellular particles) and methodologically (more indirect estimation techniques being involved than with whole cells or tissues) and that more adequate information can be found in treatises specializing in work with mitochondria.
Membrane Transport In Biology
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Author : James A. Schafer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Membrane Transport In Biology written by James A. Schafer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
Well over one decade has passed since the appearance of the original four volumes of Membrane Transport in Biology. Since the publication of the last volume there have been spectacular advances in this field. These advances have been in part the result of the application of exciting new methodologies, and in part the result of new insights into the regulation and integration of transport processes. This volume, as well as a sixth volume, which is in preparation, are intended to cover key areas in which the development has been particularly striking. For many years the trend in studies of membrane transport had been that of increasing specialization with regard to the transporter of interest and of the cell or tissue studied. This trend was supported by the enormous number of publications directed at understanding the cellular physiology of specific organ systems and tissues, and also by the fact that different tissues often seemed to react so differently to the same conditions that mechanisms unique to each appear to be at play. One of the happy developments in recent years has been the realization that this apparent disparity of behaviors in different tissues is based on varying combinations of a limited number of transport mechanisms, all mediated by the same or similar proteins. Some of these transport proteins have already been isolated and analyzed with respect to amino acid sequence whereas others are just entering this phase.
Transport Across Natural And Modified Biological Membranes And Its Implications In Physiology And Therapy
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Author : Julita Kulbacka
language : en
Publisher: Springer
Release Date : 2017-10-17
Transport Across Natural And Modified Biological Membranes And Its Implications In Physiology And Therapy written by Julita Kulbacka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-17 with Medical categories.
This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).
Membrane Transport
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Author : Daniel C. Tosteson
language : en
Publisher: Springer
Release Date : 2013-05-27
Membrane Transport written by Daniel C. Tosteson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Medical categories.
This is a fascinating collection of personal accounts which is a "must read" for anyone interested in membrane transport or the history of the development of the current picture of membrane transport physiology. This delightful book could serve variously as a history for investigators and historians or as a textbook for advanced students. No biology or medical library should be without it
Textbook Of Membrane Biology
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Author : Rashmi Wardhan
language : en
Publisher: Springer
Release Date : 2018-01-10
Textbook Of Membrane Biology written by Rashmi Wardhan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-10 with Science categories.
This book provides a comprehensive overview of the basic principles, concepts, techniques and latest advances in the field of biomembranes and membrane-associated processes. With new emerging technologies and bioinformatics tools, this is a promising area for future study and research. The book discusses the composition, fluidity and dynamic nature of phospholipid bilayers, which vary with cell/organelle type and function. It describes the various types of transport proteins that facilitate the transport of polar and nonpolar molecules across the membrane actively or passively via ion-channels or through porins. It also explores the many cellular functions membranes participate in: (1) energy transduction, which includes the electron transport chain in inner membrane of mitochondria and bacterial cytoplasmic membrane and photosynthetic electron transport in thylakoid membranes in chloroplast and photosynthetic bacterial membranes; (2) cell–cell communication involving various signal transduction pathways triggered by activated membrane receptors; (3) cell–cell interactions involving various types of adhesion and receptor proteins; (4) nerve transmission involving opening and closing of voltage gated ionic channels; and (5) intracellular transport involving the processes of endocytosis, exocytosis, vesicular transport of solutes between intracellular compartments, membrane fusion and membrane biogenesis.
Transport Across Natural And Modified Biological Membranes And Its Implications In Physiology And Therapy
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Author : Julita Kulbacka
language : en
Publisher: Springer
Release Date : 2017-10-04
Transport Across Natural And Modified Biological Membranes And Its Implications In Physiology And Therapy written by Julita Kulbacka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-04 with Medical categories.
This book elucidates the mechanisms involved in biological membrane functions. It describes the new modalities and characterization for basic in vitro as well as computer models of biological membranes. Biological membranes are analyzed in terms of advances in molecular dynamics. The individual chapters provide an in depth analysis of images from various biological models. The potential of membrane models in the context of treatment trials is discussed. The authors present new insights and current concepts for treatment procedures (nanocarriers, electroporation, channel blockers).