Metabolic Profiling
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Metabolic Profiling
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Author : Olga Deda
language : en
Publisher: Springer Nature
Release Date : 2025-01-15
Metabolic Profiling written by Olga Deda and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-15 with Science categories.
This second edition volume expands on the previous edition with new chapters and updated discussions on the latest advancements in the development and practice of metabolic phenotyping. The chapters in this book cover topics such as quality control in untargeted metabolic phenotyping; implementation of quality assurances processes; careful bio- and chemoinformatic data analysis; using reversed-phase and ion-pair LC-MS; quantitative lipid analysis using supercritical fluid chromatography (SFC-MS) and the targeted determination of metanephrines in urine via LC-MS/MS. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and comprehensive, Metabolic Profiling: Methods and Protocols, Second Edition is a valuable resource for all researchers who are interested in incorporating best practices in metabolic phenotyping and learning more about this rapidly advancing field.
Metabolic Profiling
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Author : Martin Grootveld
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014-11-06
Metabolic Profiling written by Martin Grootveld and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-06 with Science categories.
Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a 'fingerprint' of their biomolecular/metabolic status. Therefore, if applied correctly, valuable information regarding disease indicators, disease strata and sub-strata and disease activities can be obtained. This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail. The book gives particular reference to cautionary measures that must be applied to the diagnosis and classification of these conditions or physiological criteria. Comprehensively covering a wide range of topics, of particular interest is the focus on experimental design and 'rights and wrongs' of the techniques commonly applied by researchers, and the very recent development of powerful 'Pattern Recognition' techniques. The book provides a detailed introduction to the area, applications and common pitfalls of the techniques discussed before moving into detailed coverage of specific disease areas, each highlighted in individual chapters. This title will provide an invaluable resource to Medicinal chemists, Biochemists and toxicologists working in industry and academia.
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis
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Author : George G. Harrigan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis written by George G. Harrigan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Metabolic Profiling Of Hyperinsulinemic Horses
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Author : Julien Delarocque
language : en
Publisher: Cuvillier Verlag
Release Date : 2021-05-17
Metabolic Profiling Of Hyperinsulinemic Horses written by Julien Delarocque and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-17 with Medical categories.
Insulin dysregulation mediates the increased risk for laminitis associated with the two most common equine endocrinopathies, pituitary pars intermedia dysfunction (PPID) and the equine metabolic syndrome (EMS). This thesis aimed to describe the metabolic profile of horses with this condition to help elucidate the cause for the increased insulin production it elicits and possibly uncover some pathomechanisms leading to laminitis. Besides identifying metabolites correlated to the level of the insulin response to an oral glucose test, such as carnitine, arginine and DOPA, this project revealed the potential of such molecules in recognizing horses with insulin dysregulation without complex diagnostic tests. Additionally, it allowed to concretely quantify the reduction of the insulin response to oral carbohydrates following weight loss, while differentiating the respective metabolic impact of weight gain and worsened insulin dysregulation. Lastly, metabolites associated with subsequent laminitis were described. Altogether, the results provided new concepts for the identification of insulin dysregulation, supported an association between this condition and vascular dysfunction, helped distinguish the metabolic impact of weight variations from the effect of insulin dysregulation, and suggested that carnitine and arginine could be investigated as nutritional supplements to treat insulin dysregulation.
The Iv Latin American Metabolic Profiling Society Lamps Symposium 2022
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Author : Guillermo Moyna
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-01
The Iv Latin American Metabolic Profiling Society Lamps Symposium 2022 written by Guillermo Moyna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Science categories.
This Research Topic aims to gather the proceedings of the “IV Latin American Metabolic Profiling Society (LAMPS) Symposium”. Since the first Symposium in 2014 in Lima, Perú, the Latin American Metabolic Profiling Society (LAMPS) has periodically gathered researchers from the region to share their work. Though the discipline is still underdeveloped in Latin America, past meetings held in Rosario, Argentina, in 2016, and in Rio de Janeiro, Brazil, in 2018, have showcased presentations in all areas of metabolomics. After a hiatus of two years imposed by the COVID-19 pandemic, the fourth edition of the LAMPS Symposium will be held in Cartagena de Indias, Colombia, this coming November (2nd - 4th). As in past editions, the high profile program of the Symposium will provide NMR spectroscopists and mass spectrometrists with a unique opportunity to present their latest results and give younger researchers a space to connect with other colleagues. By sharing new findings and discussing progress in metabolic profiling, this meeting will contribute to a deeper understanding of metabolomics research. To accompany the IV LAMPS Symposium, this Research Topic will not only be an opportunity for those presenting their research at the event to divulge full versions of their work, but will also receive contributions from other researchers in the field as well. While research in Latin America will be the primary focus, submissions that display the impact of metabolomics in all areas of health, nutrition, and agriculture will also be open to Latin American researchers elsewhere around the globe.
Transcriptome Metabolic Profiling An Insight Into The Abiotic Stress Response Crosstalk In Plants
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Author : Poonam Yadav
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-21
Transcriptome Metabolic Profiling An Insight Into The Abiotic Stress Response Crosstalk In Plants written by Poonam Yadav and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-21 with Science categories.
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis
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Author : George G. Harrigan
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-01-31
Metabolic Profiling Its Role In Biomarker Discovery And Gene Function Analysis written by George G. Harrigan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-31 with Medical categories.
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Metabolomics Metabonomics And Metabolite Profiling
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Author : William J. Griffiths
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Metabolomics Metabonomics And Metabolite Profiling written by William J. Griffiths and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.
Proceedings Of The 11th International Wheat Genetics Symposium 24 29 August 2008 Brisbane Qld Australia
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Author : Rudi Appels
language : en
Publisher: Sydney University Press
Release Date : 2008
Proceedings Of The 11th International Wheat Genetics Symposium 24 29 August 2008 Brisbane Qld Australia written by Rudi Appels and has been published by Sydney University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
The papers herein are volume 1 of the proceedings of the 11th International Wheat Genetics Symposium, held in Brisbane, Australia, in 2008. The series presents the science of the genetic sciences applied to bread and durum wheats and other species.
Nmr Spectroscopy In Pharmaceutical Analysis
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Author : Iwona Wawer
language : en
Publisher: Elsevier
Release Date : 2017-07-07
Nmr Spectroscopy In Pharmaceutical Analysis written by Iwona Wawer and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-07 with Science categories.
For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. - Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience - Considers international pharmacopoeias, addressing the concern for licensing - Features the work of academics and researchers, appealing to a broad readership