Metabolism And Enzymology Of Nucleic Acids
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Metabolism And Enzymology Of Nucleic Acids
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Author : Jan Zelinka
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metabolism And Enzymology Of Nucleic Acids written by Jan Zelinka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Papers of the June 1987 meeting. Sponsored by the Slovak Academy of Sciences, most contributors are from Eastern European countries. Beyond the obvious nucleic acids and nucleases, topics include methylation, molecular cloning, gene expression. Annotation copyright Book News, Inc. Portland, Or.
Metabolism And Enzymology Of Nucleic Acids
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Author : Jan Zelinka
language : en
Publisher: Springer
Release Date : 2011-09-27
Metabolism And Enzymology Of Nucleic Acids written by Jan Zelinka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-27 with Medical categories.
Rna Metabolism And Gene Expression In Archaea
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Author : Béatrice Clouet-d'Orval
language : en
Publisher: Springer
Release Date : 2017-10-28
Rna Metabolism And Gene Expression In Archaea written by Béatrice Clouet-d'Orval and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-28 with Science categories.
This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. From synthesis to degradation and the implications of gene expression, it presents the current state of knowledge on archaeal RNA biology in 13 chapters. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system. While Archaea have long been considered exotic microbial extremophiles, they are now increasingly being recognized as important model microorganisms for the study of molecular mechanisms conserved across the three domains of life, and with regard to the relevance of similarities and differences to eukaryotes and bacteria. This unique book offers a valuable resource for all readers interested in the regulation of gene expression in Archaea and RNA metabolism in general.
Nuclease Methods And Protocols
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Author : Catherine H. Schein
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Nuclease Methods And Protocols written by Catherine H. Schein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
Nucleases, enzymes that restructure or degrade nucleic acid polymers, are vital to the control of every area of metabolism. They range from “housekeeping” enzymes with broad substrate ranges to extremely specific tools (1). Many types of nucleases are used in lab protocols, and their commercial and clinical uses are expanding. The purpose of Nuclease Methods and Protocols is to introduce the reader to some we- characterized protein nucleases, and the methods used to determine their activity, structure, interaction with other molecules, and physiological role. Each chapter begins with a mini-review on a specific nuclease or a nuclease-related theme. Although many chapters cover several topics, they were arbitrarily divided into five parts: Part I, “Characterizing Nuclease Activity,” includes protocols and assays to determine general (processive, distributive) or specific mechanisms. Methods to assay nuclease products, identify cloned nucleases, and determine their physiological role are also included here. Part II, “Inhibitors and Activators of Nucleases,” summarizes assays for measuring the effects of other proteins and small molecules. Many of these inhibitors have clinical relevance. Part III, “Relating Nuclease Structure and Function,” provides an overview of methods to determine or model the 3-D structure of nucleases and their complexes with substrates and inhibitors. A 3-D structure can greatly aid the rational design of nucleases and inhibitors for specific purposes. Part IV, “Nucleases in the Clinic,” summarizes assays and protocols suitable for use with t- sues and for nuclease based therapeutics.
Ribonucleases
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Author : Allen W. Nicholson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-10-06
Ribonucleases written by Allen W. Nicholson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-06 with Science categories.
Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5’ or 3’ ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.
Rna Metabolism In Mitochondria
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Author : Jorge Cruz-Reyes
language : en
Publisher: Springer
Release Date : 2018-06-12
Rna Metabolism In Mitochondria written by Jorge Cruz-Reyes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with Science categories.
This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5′ and 3′ ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.
Ionizing Radiations And Cell Metabolism
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Author : G. E. W. Wolstenholme
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-14
Ionizing Radiations And Cell Metabolism written by G. E. W. Wolstenholme and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-14 with Science categories.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Metabolic Pathways
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Author : David Greenberg
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Metabolic Pathways written by David Greenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Metabolic Pathways, Third Edition: Volume IV: Nucleic Acids, Protein Synthesis, and Coenzymes focuses on the metabolic pathways of the major biological constituents of living organisms, namely, nucleic acids, proteins, and coenzymes. The biosynthesis and metabolism of purines and pyrimidines, nucleotides, riboflavin and related compounds, and vitamin B6 are discussed. The biogenesis and metabolism of thiamine and folic acid are also considered. This volume is comprised of seven chapters and begins with an analysis of metabolic control and enzymology of purines and pyrimidines such as inosinic acid and nucleotides. The next chapter is devoted to the biosynthesis and metabolism of nucleotides and nucleic acids, making reference to deoxyribonucleotides as well as RNA and DNA. Some of the reactions involving nucleotides are classified and briefly discussed. The reader is then introduced to protein synthesis, paying particular attention to the chemical features of the synthesis of the peptide bond and the characteristics of the genetic code implicated in this process. The remaining chapters focus on riboflavin and related compounds, thiamine, folic acid, and vitamin B6. This book will be a useful resource for biochemists and biologists.
Nucleic Acid Polymerases
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Author : Katsuhiko S. Murakami
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-22
Nucleic Acid Polymerases written by Katsuhiko S. Murakami and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.
Protein Nucleic Acid Interactions
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Author : Phoebe A. Rice
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008-05-22
Protein Nucleic Acid Interactions written by Phoebe A. Rice and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-22 with Science categories.
This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.