Metabolism And Metabolomics Of Liver In Health And Disease
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Metabolism And Metabolomics Of Liver In Health And Disease
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Author : Walter Wahli
language : en
Publisher: MDPI
Release Date : 2021-02-19
Metabolism And Metabolomics Of Liver In Health And Disease written by Walter Wahli and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-19 with Science categories.
Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
Metabolism And Metabolomics Of Liver In Health And Disease
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Author : Walter Wahli
language : en
Publisher:
Release Date : 2021
Metabolism And Metabolomics Of Liver In Health And Disease written by Walter Wahli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
Metabolomics In Health And Disease Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-02-26
Metabolomics In Health And Disease Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-26 with Science categories.
Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience
Liver Metabolism And Diseases
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Author : Joseph Curtis
language : en
Publisher: Murphy & Moore Publishing
Release Date : 2023-09-26
Liver Metabolism And Diseases written by Joseph Curtis and has been published by Murphy & Moore Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Liver is an integral part of the process of metabolism. It helps in the preservation and regulation of the lipid and glucose levels in the body, as well as in energy metabolism. The most common metabolic diseases which can affect the liver are Wilson disease, hereditary hemochromatosis, and Alpha-I antitrypsin deficiency (AATD). Some of the other types of disorders which affect the liver are infections, immune system issues, cancers, and heritable conditions. One of the upcoming methods of study which is used to study the cell metabolism within the liver is metabolomics. It refers to the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Metabolomics has a very high potential to detect biomarker candidates for the prospective advancement of new therapeutics. The book aims to shed light on some of the unexplored aspects of liver metabolism and the recent researches in this field with respect to liver diseases. It will provide comprehensive knowledge to both medical students and professionals.
The Human Gut Liver Axis In Health And Disease
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Author : Aleksander Krag
language : en
Publisher: Springer
Release Date : 2018-11-09
The Human Gut Liver Axis In Health And Disease written by Aleksander Krag and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-09 with Medical categories.
The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.
A Practical Guide To Metabolomics Applications In Health And Disease
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Author : Julijana Ivanisevic
language : en
Publisher: Springer Nature
Release Date :
A Practical Guide To Metabolomics Applications In Health And Disease written by Julijana Ivanisevic and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Liver Metabolism And Fatty Liver Disease
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Author : Oren Tirosh
language : en
Publisher: CRC Press
Release Date : 2014-08-27
Liver Metabolism And Fatty Liver Disease written by Oren Tirosh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-27 with Medical categories.
Nonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to nonalcoholic steatohepatitis and cirrhosis. The significant prevalence of this disease—between 15 and 45 percent of the general population—means that it contributes to an increased burden of ill health both today and in the future. Liver Metabolism and Fatty Liver Disease addresses the current understanding of the development of nonalcoholic fatty liver disease as well as the clinical aspects of the disease by examining the current knowledge surrounding metabolism in the liver. The book discusses various topics including the involvement of oxidative stress, metabolic effects, and inflammation as well as the effect of nutrition on the development and progression of the disease.
Metabolism Of Human Diseases
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Author : Eckhard Lammert
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-06-02
Metabolism Of Human Diseases written by Eckhard Lammert and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-02 with Medical categories.
“Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “Metabolism of Human Diseases” is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.
Metabolism And Nutrition In Liver Disease
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Author : E. Holm
language : en
Publisher: Springer Science & Business Media
Release Date : 1985-10-31
Metabolism And Nutrition In Liver Disease written by E. Holm and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-10-31 with Medical categories.
Metabonomics And Gut Microbiota In Nutrition And Disease
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Author : Sunil Kochhar
language : en
Publisher: Springer
Release Date : 2014-10-21
Metabonomics And Gut Microbiota In Nutrition And Disease written by Sunil Kochhar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-21 with Medical categories.
This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.