Metal Ions In Gene Regulation
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Metal Ions In Gene Regulation
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Author : Simon Silver
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metal Ions In Gene Regulation written by Simon Silver and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
Metal Ions In Biological Systems
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Author : Astrid Sigel
language : en
Publisher: CRC Press
Release Date : 1996-02-05
Metal Ions In Biological Systems written by Astrid Sigel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-05 with Science categories.
Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.
Structural And Catalytic Roles Of Metal Ions In Rna
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Author : Astrid Sigel
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2015-07-24
Structural And Catalytic Roles Of Metal Ions In Rna written by Astrid Sigel and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-24 with Science categories.
The discovery of ribozymes nearly 30 years ago triggered a huge interest in the chemistry and biology of RNAs. Much of the recently made progress focusing on metal ions is addressed in MILS 9. This book, written by 28 internationally recognized experts from 8 nations, provides a most up-to-date view and is thus of special relevance for colleagues teaching courses in biological inorganic chemistry and for researchers dealing, e.g., with nucleic acids, gene expression, and enzymology, but also for those in analytical and bioinorganic chemistry or biophysics. Structural and Catalytic Roles of Metal Ions in RNA describes in an authoritative and timely manner in 12 stimulating chapters, supported by nearly 1600 references, 13 tables, and 75 illustrations, mostly in color, metal ion-binding motifs, methods to detect and characterize metal ion-binding sites, and the role of metal ions in folding and catalysis. It deals with diffuse metal ion binding, RNA quadruplexes, the regulation of riboswitches, metal ions and ribozymes, including artificial ribozymes. The spliceosome, the ribosome, ribozymes involving redox cofactors as well as the binding of kinetically inert metal ions to RNA are also covered.
Metal Complex Dna Interactions
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Author : Nick Hadjiliadis
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-30
Metal Complex Dna Interactions written by Nick Hadjiliadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-30 with Science categories.
Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.
The Role Of Metal Ions In Biology Biochemistry And Medicine
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Author : Michael Moustakas
language : en
Publisher: MDPI
Release Date : 2021-09-06
The Role Of Metal Ions In Biology Biochemistry And Medicine written by Michael Moustakas and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-06 with Science categories.
Metal ions are fundamental elements for the maintenance of the lifespan of plants, animals and humans. Their substantial role in biological systems was recognized a long time ago. They are essential for the maintenance of life and their absence can cause growth disorders, severe malfunction, carcinogenesis or death. They are protagonists as macro- or microelements in several structural and functional roles, participating in many bio-chemical reactions, and arise in several forms. They participate in intra- and intercellular communications, in maintaining electrical charges and osmotic pressure, in photosynthesis and electron transfer processes, in the maintenance of pairing, stacking and the stability of nucleotide bases and also in the regulation of DNA transcription. They contribute to the proper functioning of nerve cells, muscle cells, the brain and the heart, the transport of oxygen and to many other biological processes up to the point that we cannot even imagine a life without metals. In this book, the papers published in the Special Issue “The Role of Metal Ions in Biology, Biochemistry and Medicine” are summarized, providing a picture of metal ion uses in biology, biochemistry and medicine, but also pointing out the toxicity impacts on plants, animals, humans and the environment.
Metals In Biology
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Author : Lawrence Berliner Graeme Hanson
language : en
Publisher:
Release Date : 2010-09-13
Metals In Biology written by Lawrence Berliner Graeme Hanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-13 with categories.
Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic struct.
Metals In Biology
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Author : Graeme Hanson
language : en
Publisher: Springer
Release Date : 2010-03-11
Metals In Biology written by Graeme Hanson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-11 with Medical categories.
Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes. This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.
Metals And Genetics
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Author : Bibudhendra Sarkar
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metals And Genetics written by Bibudhendra Sarkar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the past few years, major scientific discoveries have greatly contributed to our understanding of the relationship between metals and genetics. The fields which have contrib uted to this area range from Clinical Medicine and Genetics to Biochemistry and Chemistry. The aim of this book is to bring together investigators from these diverse fields to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume begins with a tribute to the late Karen Wetterhahn, an outstanding scien tist in the field, who will be sadly missed by her friends and colleagues because of her un timely death. The book has 28 chapters contributed by scientists who are internationally known for their expertise and outstanding research. The subject matters are divided into five major sections. The first section discusses genetic response to environmental expo sure to metals. Potentially devastating health crises have been reported in recent years from several parts of the world, which stem from environmental exposure to metals. In this section, authors report their findings on the effects and influence of metals in gene ex pression and their consequences to human health. The section on metal carcinogenesis and metal caused DNA damage, presents the latest advances in our knowledge of the molecu lar mechanisms of metal-induced mutagenesis and carcinogenesis. This topic is at the very heart of our understanding of how cancer may be caused by various metals.
Cellular And Molecular Biology Of Metals
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Author : Rudolfs K. Zalups
language : en
Publisher: CRC PressI Llc
Release Date : 2010-05-21
Cellular And Molecular Biology Of Metals written by Rudolfs K. Zalups and has been published by CRC PressI Llc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-21 with Science categories.
With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic. This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function. The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level.
Metallothioneins And Related Chelators
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Author : Astrid Sigel
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2015-07-24
Metallothioneins And Related Chelators written by Astrid Sigel and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-24 with Science categories.
These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.