Microbial Genomic Islands In Adaptation And Pathogenicity
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Microbial Genomic Islands In Adaptation And Pathogenicity
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Author : Indra Mani
language : en
Publisher: Springer Nature
Release Date : 2023-03-31
Microbial Genomic Islands In Adaptation And Pathogenicity written by Indra Mani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-31 with Science categories.
This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms.
Host Adaptation Virulence And Evolution
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Author : Javid Ahmad Parray
language : en
Publisher: Academic Press
Release Date : 2025-02-24
Host Adaptation Virulence And Evolution written by Javid Ahmad Parray and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-24 with Science categories.
Microbial Genomics: Host Adaptation, Virulence, and Evolution covers different aspects of microbial genomics, metagenomics, and functional studies of microbes that have provided a significant understanding of microbial-host interactions, virulence function, host adaptation mechanisms, including microbial evolution. Microbial Genomics: Host Adaptation, virulence, and Evolution is a comprehensive source on the latest updates and applications of microbial genomics information to understand the plant, microbe interaction, host adaptation, virulence nature of the infectious pathogen, microbial evolution, host-pathogen interactions contribute to shaping the genetic diversity of both organisms. Sections include an introduction to Microbial Genomics, followed by sections on Plant Microbiome, Genome Editing Prospecting and Approaches, Microbial virulanse and disease incidence. The final section of the book covers Microbial Genomics and evolutionary concepts. "Microbial Genomics: Host Adaptation, virulence, and Evolution" is a valuable resource for faculty members, researchers, and undergraduate and postgraduate students at universities, medical research labs, industries, and government agencies that are interested in the microbial science specific to the microbial genome, virulence function of pathogenic microbes, host adaptation, evolution of microbes, and all other disciplines related to molecular microbiology. - Presents the latest developments and progress on microbial genome and metagenome research and findings - Assesses the advancements in the study of microbial virulence gene function, adaptation, and infectious pathogen evolution - Provides insights about the progress and prospect of microbial genome editing
Crispr Cas Based Genome Editing For Treating Human Diseases Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-09-11
Crispr Cas Based Genome Editing For Treating Human Diseases Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-11 with Science categories.
CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A, Volume 208 represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and more. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source.This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. In addition, it highlights a number of aspects of the CRISPR-Cas systems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest. - Updares on CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease and fungal disease - Discusses stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders - Includes commentary on CRISPR in autoimmune and blood disorders
Phage Therapy Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-09-22
Phage Therapy Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-22 with Science categories.
Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform their research with great interest. Chapters in this new release cover An introduction to bacteriophage and their therapeutic applications, Isolation, screening and characterization of phage, Synthetic phage and their application in phage therapy, Phage engineering for development of diagnostic tools, Phage design and directed evolution to evolve phage for therapy, and more. Additional sections cover Host-phage interactions and modelling for therapy, Phage and phage cocktails formulations, Phage for treatment of Escherichia coli infection, Phage for treatment of Klebsiella pneumoniae infection, Phage for treatment of Salmonella spp infection, Phage for treatment of Staphylococcus aureus infection, and Phages for treatment of Acinetobacter baumannii infection. - Includes discussions on phage isolation, screening and characterization - Covers synthetic phage, phage for diagnostic, directed evolution and host interaction - Presents the latest on phage for treatment of bacterial infections
Microbial Pathogenomics
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Author : H. de Reuse
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2009-08-27
Microbial Pathogenomics written by H. de Reuse and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-27 with Science categories.
Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'. 'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.
Microbial Diversity In The Genomic Era
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Author : Surajit Das
language : en
Publisher: Academic Press
Release Date : 2018-09-20
Microbial Diversity In The Genomic Era written by Surajit Das and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-20 with Science categories.
Microbial Diversity in the Genomic Era presents insights on the techniques used for microbial taxonomy and phylogeny, along with their applications and respective pros and cons. Though many advanced techniques for the identification of any unknown bacterium are available in the genomics era, a far fewer number of the total microbial species have been discovered and identified to date. The assessment of microbial taxonomy and biosystematics techniques discovered and practiced in the current genomics era with suitable recommendations is the prime focus of this book. - Discusses the techniques used for microbial taxonomy and phylogeny with their applications and respective pros and cons - Reviews the evolving field of bacterial typing and the genomic technologies that enable comparative analysis of multiple genomes and the metagenomes of complex microbial environments - Provides a uniform, standard methodology for species designation
Pathogenicity Islands And The Evolution Of Pathogenic Microbes
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Author : J. Hacker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pathogenicity Islands And The Evolution Of Pathogenic Microbes written by J. Hacker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.
Stress And Environmental Regulation Of Gene Expression And Adaptation In Bacteria 2 Volume Set
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Author : Frans J. de Bruijn
language : en
Publisher: John Wiley & Sons
Release Date : 2016-09-06
Stress And Environmental Regulation Of Gene Expression And Adaptation In Bacteria 2 Volume Set written by Frans J. de Bruijn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-06 with Science categories.
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Pathogenesis Of Bacterial Infections In Animals
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Author : John F. Prescott
language : en
Publisher: John Wiley & Sons
Release Date : 2022-08-15
Pathogenesis Of Bacterial Infections In Animals written by John F. Prescott and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-15 with Medical categories.
PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references. This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context. Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on: Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.
The Science And Applications Of Microbial Genomics
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2013-05-02
The Science And Applications Of Microbial Genomics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-02 with Science categories.
Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took more than 13 months of work to complete. Today, a microorganism's entire genome can be sequenced in a few days. Much as our view of the cosmos was forever altered in the 17th century with the invention of the telescope, these genomic technologies, and the observations derived from them, have fundamentally transformed our appreciation of the microbial world around us. On June 12 and 13, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us. Through invited presentations and discussions, participants examined the use of microbial genomics to explore the diversity, evolution, and adaptation of microorganisms in a wide variety of environments; the molecular mechanisms of disease emergence and epidemiology; and the ways that genomic technologies are being applied to disease outbreak trace back and microbial surveillance. Points that were emphasized by many participants included the need to develop robust standardized sampling protocols, the importance of having the appropriate metadata, data analysis and data management challenges, and information sharing in real time. The Science and Applications of Microbial Genomics summarizes this workshop.