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Microglia In Health And Disease

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Microglia In Health And Disease

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Author : Marie-Ève Tremblay
language : en
Publisher: Springer
Release Date : 2014-09-22

Microglia In Health And Disease written by Marie-Ève Tremblay and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Medical categories.

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Dual Role Of Microglia In Health And Disease Pushing The Balance Towards Repair

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Author : Raquel Ferreira
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-27

Dual Role Of Microglia In Health And Disease Pushing The Balance Towards Repair written by Raquel Ferreira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Microglia In Health And Disease A Unique Immune Cell Population

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Author : Alessandro Michelucci
language : en
Publisher: Frontiers Media SA
Release Date : 2018-10-05

Microglia In Health And Disease A Unique Immune Cell Population written by Alessandro Michelucci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-05 with categories.

Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.

Microglia In Health And Disease A Unique Immune Cell Population

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Author :
language : en
Publisher:
Release Date : 2018

Microglia In Health And Disease A Unique Immune Cell Population written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

Glial Cells In Health And Disease Of The Cns

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Author : Rommy von Bernhardi
language : en
Publisher: Springer
Release Date : 2016-10-06

Glial Cells In Health And Disease Of The Cns written by Rommy von Bernhardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-06 with Medical categories.

A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.

Microglia

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Author : Olga Garaschuk
language : en
Publisher: Humana
Release Date : 2020-08-14

Microglia written by Olga Garaschuk and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-14 with Medical categories.

This book presents a comprehensive toolkit of versatile techniques for studying microglia under different experimental settings along with a brief summary of knowledge, accumulated in microglial research over the last decades. Beginning with recently discovered roles of microglia in health and disease, the volume continues by covering in vitro analyses of microglia, in vivo studies, and “omics” analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microglia: Methods and Protocols serves as a vital guide to these important cells and an inspiration for scientists interested in expanding our knowledge of their role in the nervous system.

Glia In Health And Disease

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Author : Margaret S. Ho
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16

Glia In Health And Disease written by Margaret S. Ho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.

The Functional Roles Of Glial Cells In Health And Disease

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Author : Rebecca Matsas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

The Functional Roles Of Glial Cells In Health And Disease written by Rebecca Matsas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Thirty-five years ago, when Stephen Kuffler and his colleagues at Harvard initiated a new era of research on the properties and functions of neuroglial cells, very few neuro scientists were impressed at the time with the hypothesis that neuroglial cells could have another, though more subtle, role to play in the nervous system than to provide static support to neurons. Today, very few neuroscientists are unaware of the fact that multiple interactions between neurons and glial cells have been described, and that they consti tute the basis for understanding the function and the pathology of the nervous system. Glial cells outnumber neurons and make up about one-half of the bulk of the nervous system. They are divided into two major classes: first, the macroglia, which include astrocytes and oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system; and second, the microglial cells. These different classes of glial cells have different functions and contribute in different ways in the devel opment, function, and the pathology of the nervous system.

Never Resting Microglia Physiological Roles In The Healthy Brain And Pathological Implications

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Author : Amanda Sierra
language : en
Publisher: Frontiers E-books
Release Date : 2015-02-11

Never Resting Microglia Physiological Roles In The Healthy Brain And Pathological Implications written by Amanda Sierra and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-11 with Microglia categories.

Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic seeked to emphasize how the current research in neuroscience is challenged by never-resting microglia.

The Biology Of Glial Cells Recent Advances

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Author : Ishan Patro
language : en
Publisher: Springer Nature
Release Date : 2022-04-09

The Biology Of Glial Cells Recent Advances written by Ishan Patro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-09 with Medical categories.

This book reviews the role of glial cells (astrocytes, microglia, oligodendroglia, satellite cells, and Schwann cells) in neuronal health and diseases. It discusses the latest advances in understanding their origin, differentiation, and hemostasis. The book also examines the role of microglial cells in central nervous system (CNS) development, maintenance, and synaptic plasticity. Further, the book presents the functions of astrocytes in healthy CNS and their critical role in CNS disorders, including Parkinson's and Alzheimer's diseases. Notably, the book describes the pathobiology, molecular pathogenesis, stem cells, and imaging characteristics of gliomas. It defines the role of glial cells in regulating iron homeostasis and their effect on the neurodegeneration of neurons. Lastly, it covers the structure, function, and pathology of oligodendrocytes and their role in neuronal health and disease.

Microglia In Health And Disease

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