Microrna Regulation In Health And Disease
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Microrna Regulation In Health And Disease
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Author : Clifford J. Steer
language : en
Publisher: MDPI
Release Date : 2020-02-21
Microrna Regulation In Health And Disease written by Clifford J. Steer and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-21 with Science categories.
MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
Microrna Regulation In Health And Disease
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Author : Clifford Steer
language : en
Publisher:
Release Date : 2020
Microrna Regulation In Health And Disease written by Clifford Steer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biology (General) categories.
MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
Microrna
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Author : Jaishree Paul
language : en
Publisher: CRC Press
Release Date : 2018-02-19
Microrna written by Jaishree Paul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-19 with Medical categories.
This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.
Microrna
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Author : Jaishree Paul
language : en
Publisher: CRC Press
Release Date : 2018
Microrna written by Jaishree Paul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with MicroRNA categories.
"A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."
Micrornas In Health And Disease
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Author : Milena Rizzo
language : en
Publisher:
Release Date : 2024-04-29
Micrornas In Health And Disease written by Milena Rizzo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-29 with Science categories.
This Special Issue delves into the intricate world of miRNAs as modulators of gene expression regulation. These small non-coding RNAs are at the heart of post-transcriptional modulation of gene activity, affecting a myriad of biological processes. The curated selection of articles within this issue offers insights into the roles of miRNAs in health and disease, emphasizing their potential value as therapeutic targets and biomarkers. Featuring original research and in depth-reviews, this Special Issue covers recent miRNA advancements, detailing their regulatory networks and action mechanisms. It highlights new miRNA-linked therapeutic targets and circulating miRNAs as cell-to-cell communication intermediaries. The issue also examines extracellular miRNAs (ex-miRNAs) and their functions, highlighting their presence in biological fluids and their potential utility in clinical diagnostics and disease monitoring. Challenges in miRNA quantification and technological advances for precise measurement are also discussed. The issue traverses the less-charted territories of miRNA research, such as the discovery of small nucleolar-derived miRNAs and the elucidation of transposable elements as unexpected constituents of the miRNA regulatory network. Overall, this collection showcases the evolving nature of miRNA research, offering valuable perspectives for future scientific inquiry and medical innovation. It reflects the drive to decode gene regulation complexities, providing insights for health professionals and researchers at the forefront of gene regulation research.
Microrna Regulation And Clinical Applications
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Author : Shane Eakin
language : en
Publisher: Murphy & Moore Publishing
Release Date : 2023-09-26
Microrna Regulation And Clinical Applications written by Shane Eakin and has been published by Murphy & Moore Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
MicroRNAs (miRNAs) are a class of non-coding RNAs found in plants, animals and some viruses. They play a significant role in the regulation of gene expressions and are involved in all physiological processes. These physiological processes include development and differentiation, heart function, metabolism, hemostasis, and apoptosis. The alteration of the miRNA function is associated with some diseases and disorders such as cancer, inherited diseases, cardiovascular diseases and neurodegenerative diseases. Most of the miRNAs are transcribed from DNA sequences to produce primary miRNAs, which are then processed into precursor miRNAs. These finally turn into mature miRNAs. This book provides comprehensive insights into the regulation and clinical applications of microRNA. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.
Regulatory Microrna
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Author : Y-h. Taguchi
language : en
Publisher: MDPI
Release Date : 2019-04-16
Regulatory Microrna written by Y-h. Taguchi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-16 with Science categories.
This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.
Microrna Targeted Cancer Therapy
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Author : Fazlul H. Sarkar
language : en
Publisher: Springer Science & Business
Release Date : 2014-04-22
Microrna Targeted Cancer Therapy written by Fazlul H. Sarkar and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Medical categories.
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.
Regulatory Microrna
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Author : Y-h Taguchi
language : en
Publisher:
Release Date : 2019
Regulatory Microrna written by Y-h Taguchi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biology (General) categories.
This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.
Hormones Metabolism And The Benefits Of Exercise
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Author : Bruce Spiegelman
language : en
Publisher: Springer
Release Date : 2018-03-07
Hormones Metabolism And The Benefits Of Exercise written by Bruce Spiegelman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-07 with Science categories.
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.