Mitochondria And Cancer
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Mitochondria And Cancer
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Author : Keshav Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-05
Mitochondria And Cancer written by Keshav Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-05 with Medical categories.
Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Mitochondria And Cancer
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Author : Keshav Singh
language : en
Publisher: Springer
Release Date : 2008-12-12
Mitochondria And Cancer written by Keshav Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-12 with Medical categories.
An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.
Mitochondria The Anti Cancer Target For The Third Millennium
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Author : Jiri Neuzil
language : en
Publisher: Springer
Release Date : 2014-05-26
Mitochondria The Anti Cancer Target For The Third Millennium written by Jiri Neuzil and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-26 with Medical categories.
This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.
Mitochondria As Targets For Phytochemicals In Cancer Prevention And Therapy
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Author : Dhyan Chandra
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Mitochondria As Targets For Phytochemicals In Cancer Prevention And Therapy written by Dhyan Chandra and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Science categories.
This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.
Mitochondrial Genetics And Cancer
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Author : Gabriel D. Dakubo
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-23
Mitochondrial Genetics And Cancer written by Gabriel D. Dakubo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-23 with Medical categories.
With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these ?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.
Mitochondrial Metabolism
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Author : Jalal Pourahmad
language : en
Publisher: Academic Press
Release Date : 2021-07-28
Mitochondrial Metabolism written by Jalal Pourahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.
Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies
Mitochondria As Biosynthetic Factories For Cancer Proliferation
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Author : Madrid Madrid Press
language : en
Publisher:
Release Date : 2015-12-15
Mitochondria As Biosynthetic Factories For Cancer Proliferation written by Madrid Madrid Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-15 with categories.
This open access article by various authors presents key research on Mitochondria as biosynthetic factories for cancer proliferation. Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critical biochemical functions for the synthesis of fundamental cellular components, including fatty acids, amino acids, and nucleotides. Despite the extensive interest in the glycolytic phenotype of many cancer cells, tumors contain fully functional mitochondria that support proliferation and survival. Furthermore, tumor cells commonly increase flux through one or more mitochondrial pathways, and pharmacological inhibition of mitochondrial metabolism is emerging as a potential therapeutic strategy in some cancers. Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight specific cancers where these processes are activated.
Mitochondrial Dna Mutations In Aging Disease And Cancer
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Author : Keshav K. Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Mitochondrial Dna Mutations In Aging Disease And Cancer written by Keshav K. Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.
Mitochondria In Health And In Sickness
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Author : Andrea Urbani
language : en
Publisher: Springer Nature
Release Date : 2019-08-26
Mitochondria In Health And In Sickness written by Andrea Urbani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-26 with Science categories.
Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
Tumor Cell Metabolism
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Author : Sybille Mazurek
language : en
Publisher: Springer
Release Date : 2015-01-19
Tumor Cell Metabolism written by Sybille Mazurek and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-19 with Medical categories.
The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.