Mitochondrial Metabolism
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Mitochondrial Metabolism
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Author : Jalal Pourahmad
language : en
Publisher: Academic Press
Release Date : 2021-07-28
Mitochondrial Metabolism written by Jalal Pourahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.
Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies
Mitochondrial Medicine
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Author : Anna Gvozdjáková
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Mitochondrial Medicine written by Anna Gvozdjáková and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.
Mitochondrial Biology And Experimental Therapeutics
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Author : Paulo J. Oliveira
language : en
Publisher: Springer
Release Date : 2018-03-21
Mitochondrial Biology And Experimental Therapeutics written by Paulo J. Oliveira and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-21 with Medical categories.
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
Energy Metabolism And The Regulation Of Metabolic Processes In Mitochondria
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Author : Myron Mehlman
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Energy Metabolism And The Regulation Of Metabolic Processes In Mitochondria written by Myron Mehlman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria contains papers presented at the 1972 symposium on metabolic regulation, held at the University of Nebraska Medical School in Omaha, Nebraska. The contributors provide alternative views and ideas in some aspects of metabolic regulation directly concerned with mitochondrial function. Separating 16 papers into chapters, this book first discusses the general aspects of control of the biological energy regulation and the kinetic and thermodynamic control of mitochondrial electron transport and energy coupling. It then covers significant topics on citric acid cycle, including its replenishment and depletion; anion transport and regulation; dynamics and substrate compartmentation; and feedback control. Other chapters examine the mechanisms of gluconeogenesis, lipogenesis, redox reaction, and phosphorylation in the mitochondria. Discussions on hormonal regulation of selected enzyme system directly related to mitochondrial function are provided in the concluding chapters. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts of mitochondrial function will find this book of great value.
Mitochondrial Metabolism In Ischemic Heart Disease
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Author : Shijun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Mitochondrial Metabolism In Ischemic Heart Disease written by Shijun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Medical categories.
Rna Metabolism In Mitochondria
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Author : Jorge Cruz-Reyes
language : en
Publisher: Springer
Release Date : 2018-06-12
Rna Metabolism In Mitochondria written by Jorge Cruz-Reyes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with Science categories.
This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5′ and 3′ ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.
Molecular Basis For Mitochondrial Signaling
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Author : Tatiana K. Rostovtseva
language : en
Publisher: Springer
Release Date : 2017-05-12
Molecular Basis For Mitochondrial Signaling written by Tatiana K. Rostovtseva and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-12 with Science categories.
This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.
Mitochondria In Obesity And Type 2 Diabetes
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Author : Beatrice Morio
language : en
Publisher: Academic Press
Release Date : 2019-04-13
Mitochondria In Obesity And Type 2 Diabetes written by Beatrice Morio and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-13 with Science categories.
Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes
Pharmacology Of Mitochondria
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Author : Harpreet Singh
language : en
Publisher: Springer
Release Date : 2017-08-11
Pharmacology Of Mitochondria written by Harpreet Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with Medical categories.
This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.
Mitochondria The Cell Powerhouse And Nexus Of Stress
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Author : Sabzali Javadov
language : en
Publisher: Frontiers E-books
Release Date : 2014-09-23
Mitochondria The Cell Powerhouse And Nexus Of Stress written by Sabzali Javadov and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-23 with Biology (General) categories.
Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signaling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic focuses on the role of mitochondria in the regulation of cell metabolism and signaling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases are also included and discussed.