Mitochondrial Biology And Experimental Therapeutics
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Mitochondrial Biology And Experimental Therapeutics
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Author : Paulo J. Oliveira
language : en
Publisher: Springer
Release Date : 2018-03-21
Mitochondrial Biology And Experimental Therapeutics written by Paulo J. Oliveira and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-21 with Medical categories.
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
Mitochondrial Biology
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2007-11-19
Mitochondrial Biology written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.
The field of mitochondrial research has experienced a renaissance encompassing a re-evaluation of mitochondrial biochemistry and biology. It is clear that mitochondria are not only involved in the business of ATP synthesis, but are also intimately involved in cell signaling and, particularly, in cell death.
Mitochondrial Signaling In Health And Disease
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Author : Sten Orrenius
language : en
Publisher: CRC Press
Release Date : 2012-06-20
Mitochondrial Signaling In Health And Disease written by Sten Orrenius and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-20 with Medical categories.
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Mitochondrial Remodeling And Dynamic Inter Organellar Contacts In Cardiovascular Physiopathology
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Author : Giampaolo Morciano
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-21
Mitochondrial Remodeling And Dynamic Inter Organellar Contacts In Cardiovascular Physiopathology written by Giampaolo Morciano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-21 with Science categories.
Mitochondrial Intoxication
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Author : Marcos Roberto de Oliveira
language : en
Publisher: Elsevier
Release Date : 2022-11-30
Mitochondrial Intoxication written by Marcos Roberto de Oliveira and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies that illustrate the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication
Modulation Of Oxidative Stress In Heart Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2019-11-10
Modulation Of Oxidative Stress In Heart Disease written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Modern Trends In Structural And Solid Mechanics 3
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Author : Noel Challamel
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-02
Modern Trends In Structural And Solid Mechanics 3 written by Noel Challamel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.
This book comprised of three separate volumes presents the recent developments and research discoveries in structural and solid mechanics; it is dedicated to Professor Isaac Elishakoff. This third volume is devoted to non-deterministic mechanics. Modern Trends in Structural and Solid Mechanics 3 has broad scope, covering topics such: design optimization under uncertainty, interval field approaches, convex analysis, quantum inspired topology optimization and stochastic dynamics. The book is illustrated by many applications in the field of aerospace engineering, mechanical engineering, civil engineering, biomedical engineering and automotive engineering. This book is intended for graduate students and researchers in the field of theoretical and applied mechanics.
Multifunctional Nanocarriers
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Author : Neelesh Kumar Mehra
language : en
Publisher: Elsevier
Release Date : 2022-08-20
Multifunctional Nanocarriers written by Neelesh Kumar Mehra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-20 with Technology & Engineering categories.
Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale
Mitochondrial Biology
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2007-10-22
Mitochondrial Biology written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-22 with Science categories.
With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.
Introductory Review On Sirtuins In Biology Aging And Disease
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Author : Leonard Guarente
language : en
Publisher: Academic Press
Release Date : 2018-04-20
Introductory Review On Sirtuins In Biology Aging And Disease written by Leonard Guarente and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-20 with Science categories.
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses