Model Organisms In Inflammation And Cancer
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Model Organisms In Inflammation And Cancer
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Author : Yiorgos Apidianakis
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-17
Model Organisms In Inflammation And Cancer written by Yiorgos Apidianakis and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-17 with Cancer categories.
A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.
Mouse As A Model Organism
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Author : Cord Brakebusch
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-29
Mouse As A Model Organism written by Cord Brakebusch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-29 with Medical categories.
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.
Inflammation And Cancer
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Author : Brendan J. Jenkins
language : en
Publisher: Springer Nature
Release Date : 2023-06-24
Inflammation And Cancer written by Brendan J. Jenkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-24 with Medical categories.
This second edition volume expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers. Part Two covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Inflammation and Cancer: Methods and Protocols, Second Edition is a valuable resource for those with a diverse range of laboratory-based experience, ranging from novice undergraduate students to established basic or clinical researchers who wish to diversify their existing portfolio of practical knowledge in the field.
Physics Of Cancer
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Author : Claudia Mierke
language : en
Publisher: Iph001
Release Date : 2018-10-24
Physics Of Cancer written by Claudia Mierke and has been published by Iph001 this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Science categories.
This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
Model Organisms A Precious Resource For Understanding Of The Molecular Mechanisms Underlying Human Physiology And Disease
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Author : Maria Grazia Giansanti
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-20
Model Organisms A Precious Resource For Understanding Of The Molecular Mechanisms Underlying Human Physiology And Disease written by Maria Grazia Giansanti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with categories.
The Physics Of Cancer
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Author : Caterina A. M. La Porta
language : en
Publisher: Cambridge University Press
Release Date : 2017-04-20
The Physics Of Cancer written by Caterina A. M. La Porta and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-20 with Science categories.
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
Recent Advances In Immunology To Target Cancer Inflammation And Infections
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Author : Jagat Kanwar
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-05-09
Recent Advances In Immunology To Target Cancer Inflammation And Infections written by Jagat Kanwar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-09 with Medical categories.
Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest.
Animal Modeling In Cancer
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Author : Vladimir Korinek
language : en
Publisher:
Release Date : 2021
Animal Modeling In Cancer written by Vladimir Korinek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.
Molecular Pathology
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Author : William B. Coleman
language : en
Publisher: Academic Press
Release Date : 2017-11-09
Molecular Pathology written by William B. Coleman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-09 with Medical categories.
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase
Immunostimulatory Oral Microbiome In Health Inflammation And Autoimmune Diseases
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Author : Marcelo Freire
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-31
Immunostimulatory Oral Microbiome In Health Inflammation And Autoimmune Diseases written by Marcelo Freire and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Medical categories.