Modeling Calcium Signaling
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Integrative Computational Modeling Of Calcium Handling And Cardiac Arrhythmias
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Author : Henry Sutanto
language : en
Publisher: Henry Sutanto
Release Date : 2021-01-01
Integrative Computational Modeling Of Calcium Handling And Cardiac Arrhythmias written by Henry Sutanto and has been published by Henry Sutanto this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-01 with Medical categories.
Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.
Models Of Calcium Signalling
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Author : Geneviève Dupont
language : en
Publisher: Springer
Release Date : 2016-06-07
Models Of Calcium Signalling written by Geneviève Dupont and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-07 with Mathematics categories.
This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Tutorials In Mathematical Biosciences Ii
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Author : James Sneyd
language : en
Publisher: Springer
Release Date : 2005-06-13
Tutorials In Mathematical Biosciences Ii written by James Sneyd and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-13 with Mathematics categories.
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Modeling Calcium Signaling
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Author : Ritu Agarwal
language : en
Publisher: Springer Nature
Release Date : 2024-06-18
Modeling Calcium Signaling written by Ritu Agarwal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Science categories.
This book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in cell biology. The book will inspire the graduate students and researchers to collaborate with experimentalists while studying the direction needed to explore the modeling literature. Organized into four chapters, the book introduces to fractional calculus and devoted to understanding the receptor activation by the ligand, that is Thrombin via fractional model incorporating the Caputo-Fabrizio fractional operator. It studies the calcium profile in red blood cells with the help of the advection-diffusion equation. The book further studies the process of buffering, aiding to the lowering of the calcium concentration in the cytosol, which rises due to calcium influx from extracellular space and intracellular storage. A mathematical model is studied to characterize the anomalous subdiffusion of cytosolic calcium.
Systems Modeling Approaches And Applications Volume Ii
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Author : Alberto Jesus Martin
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-25
Systems Modeling Approaches And Applications Volume Ii written by Alberto Jesus Martin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-25 with Science categories.
Modeling Methodologies And Tools For Molecular And Nano Scale Communications
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Author : Junichi Suzuki
language : en
Publisher: Springer
Release Date : 2017-03-15
Modeling Methodologies And Tools For Molecular And Nano Scale Communications written by Junichi Suzuki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Technology & Engineering categories.
This book reports on cutting-edge modeling techniques, methodologies and tools used to understand, design and engineer nanoscale communication systems, such as molecular communication systems. Moreover, it includes introductory materials for those who are new to the field. The book’s interdisciplinary approach, which merges perspectives in computer science, the biological sciences and nanotechnology, will appeal to graduate students and researchers in these three areas.The book is organized into five parts, the first of which describes the fundamentals of molecular communication, including basic concepts, models and designs. In turn, the second part examines specific types of molecular communication found in biological systems, such as neuronal communication in the brain. The book continues by exploring further types of nanoscale communication, such as fluorescence resonance energy transfer and electromagnetic-based nanoscale communication, in the third part, and by describing nanomaterials and structures for practical applications in the fourth. Lastly, the book presents nanomedical applications such as targeted drug delivery and biomolecular sensing.
Modeling In The Neurosciences
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Author : G. N. Reeke
language : en
Publisher: CRC Press
Release Date : 2005-03-29
Modeling In The Neurosciences written by G. N. Reeke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-29 with Mathematics categories.
Computational models of neural networks have proven insufficient to accurately model brain function, mainly as a result of simplifications that ignore the physical reality of neuronal structure in favor of mathematically tractable algorithms and rules. Even the more biologically based "integrate and fire" and "compartmental" styles of modeling suff
Computational Modeling Of Signaling Networks
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Author : Lan K. Nguyen
language : en
Publisher: Springer Nature
Release Date : 2023-04-19
Computational Modeling Of Signaling Networks written by Lan K. Nguyen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-19 with Science categories.
This volume focuses on the computational modeling of cell signaling networks and the application of these models and model-based analysis to systems and personalized medicine. Chapters guide readers through various modeling approaches for signaling networks, new methods and techniques that facilitate model development and analysis, and new applications of signaling network modeling towards systems and personalized treatment of cancer. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Modeling of Signaling Networks aims to benefit a wide spectrum of readers including researchers from the biological as well as computational systems biology communities.
Mathematical Modeling Of Biological Systems Volume I
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Author : Andreas Deutsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-15
Mathematical Modeling Of Biological Systems Volume I written by Andreas Deutsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-15 with Mathematics categories.
Volume I of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. The chapters are thematically organized into the following main areas: cellular biophysics, regulatory networks, developmental biology, biomedical applications, data analysis and model validation. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.
Mathematical Modeling Computational Intelligence Techniques And Renewable Energy
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Author : Manoj Sahni
language : en
Publisher: Springer Nature
Release Date : 2021-02-28
Mathematical Modeling Computational Intelligence Techniques And Renewable Energy written by Manoj Sahni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-28 with Technology & Engineering categories.
This book presents new knowledge and recent developments in all aspects of computational techniques, mathematical modeling, energy systems, applications of fuzzy sets and intelligent computing. The book is a collection of best selected research papers presented at the International Conference on “Mathematical Modeling, Computational Intelligence Techniques and Renewable Energy,” organized by the Department of Mathematics, Pandit Deendayal Petroleum University, in association with Forum for Interdisciplinary Mathematics, Institution of Engineers (IEI) – Gujarat and Computer Society of India (CSI) – Ahmedabad. The book provides innovative works of researchers, academicians and students in the area of interdisciplinary mathematics, statistics, computational intelligence and renewable energy.