Models Of Calcium Signalling
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Models Of Calcium Signalling
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Author : Geneviève Dupont
language : en
Publisher: Springer
Release Date : 2016-06-07
Models Of Calcium Signalling written by Geneviève Dupont and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-07 with Mathematics categories.
This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Modeling Calcium Signaling
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Author : Ritu Agarwal
language : en
Publisher: Springer Nature
Release Date : 2024-06-18
Modeling Calcium Signaling written by Ritu Agarwal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Science categories.
This book focuses on the fundamental processes involved in calcium signaling through fractional mathematical modeling. The intended reader of the book is mathematically proficient students of cell biology, applied mathematics and mathematical biology who are interested in learning about modeling in cell biology. The book will inspire the graduate students and researchers to collaborate with experimentalists while studying the direction needed to explore the modeling literature. Organized into four chapters, the book introduces to fractional calculus and devoted to understanding the receptor activation by the ligand, that is Thrombin via fractional model incorporating the Caputo-Fabrizio fractional operator. It studies the calcium profile in red blood cells with the help of the advection-diffusion equation. The book further studies the process of buffering, aiding to the lowering of the calcium concentration in the cytosol, which rises due to calcium influx from extracellular space and intracellular storage. A mathematical model is studied to characterize the anomalous subdiffusion of cytosolic calcium.
Tutorials In Mathematical Biosciences Ii
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Author : James Sneyd
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-06-22
Tutorials In Mathematical Biosciences Ii written by James Sneyd and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-22 with Mathematics categories.
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Integrative Computational Modeling Of Calcium Handling And Cardiac Arrhythmias
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Author : Henry Sutanto
language : en
Publisher: Henry Sutanto
Release Date : 2021-01-01
Integrative Computational Modeling Of Calcium Handling And Cardiac Arrhythmias written by Henry Sutanto and has been published by Henry Sutanto this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-01 with Medical categories.
Cardiomyocyte calcium handling is a major determinant of excitation-contraction coupling. Alterations in one or more calcium-handling proteins may induce arrhythmias through the formation of ectopic activity, direct and indirect ion-channel regulation, and structural remodeling. Due to the complex and tight interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Multiscale computational studies performed in close collaboration with laboratory experiments create new opportunities to unravel the mechanisms of arrhythmogenesis. This thesis describes the roles of integrative computational modeling in unraveling the arrhythmogenic consequences of calcium-handling abnormalities.
Receptors Models For Binding Trafficking And Signaling
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Author : Douglas A. Lauffenburger
language : en
Publisher: Oxford University Press
Release Date : 1996-05-02
Receptors Models For Binding Trafficking And Signaling written by Douglas A. Lauffenburger and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-02 with Medical categories.
This book offers a bridge at the interface between engineering and cell biology, demonstrating how a mathematical modelling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor ligand interactions. Model frameworks are described over the entire spectrum of receptor processes, from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioural functions they govern, including proliferation, adhesion, and migration.
Cellular Potts Models
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Author : Marco Scianna
language : en
Publisher: CRC Press
Release Date : 2013-03-26
Cellular Potts Models written by Marco Scianna and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-26 with Mathematics categories.
A flexible, cell-level, and lattice-based technique, the cellular Potts model accurately describes the phenomenological mechanisms involved in many biological processes. Cellular Potts Models: Multiscale Extensions and Biological Applications gives an interdisciplinary, accessible treatment of these models, from the original methodologies to the latest developments. The book first explains the biophysical bases, main merits, and limitations of the cellular Potts model. It then proposes several innovative extensions, focusing on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description. Through several biological examples, the authors demonstrate a qualitative and quantitative agreement with the relative experimental data. The cellular Potts model is increasingly being used for the mathematical modeling of a wide range of biological phenomena, including wound healing, tumor growth, and cancer cell migration. This book shows how the cellular Potts model can be used as a framework for model building and how extended models can achieve even better biological practicality, accuracy, and predictive power.
Modeling In The Neurosciences
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Author : G. N. Reeke
language : en
Publisher: CRC Press
Release Date : 2005-03-29
Modeling In The Neurosciences written by G. N. Reeke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-29 with Mathematics categories.
Computational models of neural networks have proven insufficient to accurately model brain function, mainly as a result of simplifications that ignore the physical reality of neuronal structure in favor of mathematically tractable algorithms and rules. Even the more biologically based "integrate and fire" and "compartmental" styles of modeling suff
Mathematical Modeling Computational Intelligence Techniques And Renewable Energy
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Author : Manoj Sahni
language : en
Publisher: Springer Nature
Release Date : 2021-02-28
Mathematical Modeling Computational Intelligence Techniques And Renewable Energy written by Manoj Sahni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-28 with Technology & Engineering categories.
This book presents new knowledge and recent developments in all aspects of computational techniques, mathematical modeling, energy systems, applications of fuzzy sets and intelligent computing. The book is a collection of best selected research papers presented at the International Conference on “Mathematical Modeling, Computational Intelligence Techniques and Renewable Energy,” organized by the Department of Mathematics, Pandit Deendayal Petroleum University, in association with Forum for Interdisciplinary Mathematics, Institution of Engineers (IEI) – Gujarat and Computer Society of India (CSI) – Ahmedabad. The book provides innovative works of researchers, academicians and students in the area of interdisciplinary mathematics, statistics, computational intelligence and renewable energy.
Mathematical Modeling Of Biological Systems Volume I
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Author : Andreas Deutsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-15
Mathematical Modeling Of Biological Systems Volume I written by Andreas Deutsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-15 with Mathematics categories.
Volume I of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. The chapters are thematically organized into the following main areas: cellular biophysics, regulatory networks, developmental biology, biomedical applications, data analysis and model validation. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.
Mathematical Modelling And Scientific Computing With Applications
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Author : Santanu Manna
language : en
Publisher: Springer Nature
Release Date : 2020-02-14
Mathematical Modelling And Scientific Computing With Applications written by Santanu Manna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-14 with Mathematics categories.
This book contains original research papers presented at the International Conference on Mathematical Modelling and Scientific Computing, held at the Indian Institute of Technology Indore, India, on 19–21 July 2018. Organized into 30 chapters, the book presents the recent progress and the most advanced innovations, trends, and real-world challenges encountered and solutions embraced in the applications of mathematics and scientific computing. The book will be of interests to a wide variety of researchers, students and the practicing engineers working in diverse areas of science and engineering, ranging from applied and computational mathematics, vibration problem, computer science, and numerical optimization to physics, chemistry, biology, electrical, civil, mechanical, chemical, seismology, aerospace, and medical sciences. The aim of the conference is to bring together leading academicians, scientists, researchers, engineers, and industry partners from all over the globe to exchange and share their experiences and research results on various aspects of applied mathematics and scientific computation, like, differential equation, modeling, simulation, dynamical systems, numerical analysis, matrix theory, inverse problems, and solid and fluid mechanics, computational engineering.